DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fabp and FABP5

DIOPT Version :9

Sequence 1:	NP_001027179.1	Gene:	fabp / 3772232	FlyBaseID:	FBgn0037913	Length:	157	Species:	Drosophila melanogaster
Sequence 2:	NP_001435.1	Gene:	FABP5 / 2171	HGNCID:	3560	Length:	135	Species:	Homo sapiens

Alignment Length:	108	Identity:	45/108 - (41%)
Similarity:	64/108 - (59%)	Gaps:	1/108 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KYKLDKSENFDEYMKELGVGLVTRKMGNSLSPTVEVTLEGDTYTLTTTSTFKTSAISFKLGVEFD 71
            :::|..|:.|||||||||||:..||||....|...:|.:|...|:.|.||.||:..|..||.:|:
Human    10 RWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTLKTTQFSCTLGEKFE 74

  Fly    72 EETLDGRNVKSIITLDGNKLTQEQKGD-KPTTIVREFTDNELI 113
            |.|.|||..:::.......|.|.|:.| |.:||.|:..|.:|:
Human    75 ETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLV 117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fabp	NP_001027179.1	Lipocalin	7..>107	CDD:278490	43/100 (43%)
FABP5	NP_001435.1	FABP5	6..133	CDD:381243	45/108 (42%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:24692551	24..34		6/9 (67%)
		Fatty acid binding. /evidence=ECO:0000269\|PubMed:10493790, ECO:0000269\|PubMed:24531463, ECO:0000269\|PubMed:24692551, ECO:0007744\|PDB:1B56, ECO:0007744\|PDB:4AZM, ECO:0007744\|PDB:4LKT	129..131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4015
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4779
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40966
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11955
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X240
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.850