DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fabp and CRABP1

DIOPT Version :9

Sequence 1:	NP_001027179.1	Gene:	fabp / 3772232	FlyBaseID:	FBgn0037913	Length:	157	Species:	Drosophila melanogaster
Sequence 2:	NP_004369.1	Gene:	CRABP1 / 1381	HGNCID:	2338	Length:	137	Species:	Homo sapiens

Alignment Length:	119	Identity:	48/119 - (40%)
Similarity:	75/119 - (63%)	Gaps:	8/119 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SFVGKKYKLDKSENFDEYMKELGVGLVTRKMGNSLS--PTVEVTLEGDTYTLTTTSTFKTSAISF 64
            :|.| .:|:..||||||.:|.|||..:.||:..:.:  |.||:..:||.:.:.|::|.:|:.|:|
Human     3 NFAG-TWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINF 66

  Fly    65 KLGVEFDEETLDGRNVKSIITLDG-NKLTQEQ---KGDKPTTI-VREFTDNELI 113
            |:|..|:|||:|||..:|:.|.:. ||:...|   :||.|.|. .||..::|||
Human    67 KVGEGFEEETVDGRKCRSLATWENENKIHCTQTLLEGDGPKTYWTRELANDELI 120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fabp	NP_001027179.1	Lipocalin	7..>107	CDD:278490	42/106 (40%)
CRABP1	NP_004369.1	CRABP1	2..137	CDD:381235	48/119 (40%)
		Nuclear localization signal. /evidence=ECO:0000250	21..31		4/9 (44%)
		Retinoic acid binding. /evidence=ECO:0000250	132..134
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4015
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11955
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840