DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10096 and FarO

DIOPT Version :9

Sequence 1:	NP_001027183.1	Gene:	CG10096 / 3772183	FlyBaseID:	FBgn0038032	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_652021.1	Gene:	FarO / 45707	FlyBaseID:	FBgn0023550	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	145/511 - (28%)
Similarity:	256/511 - (50%)	Gaps:	41/511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATDVQSFYKDKTVFLTGGSGFLGKVTIAKLLCTTEVKRIYVLLRAKRGQEMRERCAAWDKDPVF 65
            ::.:::.|::|..:|:|||||.:||..:.|||.:..|:|||||||.::.....:|.....:..||
  Fly     5 LSGEMEEFFEDSEIFVTGGSGVVGKALVEKLLRSCNVRRIYVLLRPRKQLTAEQRLVRLRQATVF 69

  Fly    66 GNLMKTNPEALKRVVPCGGDCQEPDLGLSNSDRQVLIDEVQIVIHTAATVRFVEPLHIALAVNTR 130
            ..|....||.|.::|...||...|.||:..|..| .:..|.:|.|.||||||.|||..|:.:|..
  Fly    70 HVLAVQKPEELDKIVAVPGDVSLPGLGIDPSMMQ-RMKGVSLVYHCAATVRFDEPLREAVRLNVG 133

  Fly   131 ATRLMIQLAKEMSHLESFVHVSTAYSNCVVEHVSERFYPEHL---TCPAEKILELLESISPE-LL 191
            .|...::.|:.:..|.:|:||||.|||..:..|..::|...:   .|     |.:::.::.: :|
  Fly   134 GTLEALKFAETLPQLRAFIHVSTFYSNPYLTRVEPKYYSSPMDWRLC-----LRMIDDVADDGML 193

  Fly   192 DKMAPALMGKYPNTYTYTKALTEQVIQKEAKDLPLSIFRPGVIIASYKEPMPGWIDNLYGPIAVL 256
            :.:...|:..:|||||:||.|.|.::......||:.::||.:::.:.::|.||:..:|.|.:.:.
  Fly   194 NALTRKLIMGFPNTYTFTKNLAESLVNDYRHRLPVIVYRPSIVLFAVEDPSPGFSPSLMGAMGLF 258

  Fly   257 YGAAFGILHITLLNLKAQAGIVPVDYCVNMVLTCAWNTARDTSIKLSP-EPPIY----------N 310
            .....|||....|....:..|.|.|..:..:| |......|...:..| :.|::          .
  Fly   259 ALVGAGILKTVYLGKDIRLDITPQDIGIKSML-CYTKMGYDIYRQGPPADLPVFLSSSCTHVPHT 322

  Fly   311 FTPNNDNLITWGGFRDKAARLRYTYPLTKMMWLPFLHCTTIPWLFRFTAIFYHLLPGYAIDLALR 375
            ||...:.:.|...:||.|        ..|.:.:|..|.|...|.::|......:||...:||.||
  Fly   323 FTQIAEQMDTLDLWRDVA--------FEKNLMIPGCHYTDKRWAYQFLVFTKQILPALILDLLLR 379

  Fly   376 LWGKKPRMIKLYDKIHKNIDILAPFVITSWSFDTVNTRKLWAKMSVEDQKLYDFN-MSSVDWDDY 439
            ::|:||.::....|.::.::::.||:..:|....|:..:..:|..  :...::|: .:..|....
  Fly   380 IFGQKPVLMSAVRKAYQTLEVMQPFMFNNWDSPGVSDMETLSKHG--EGSAFNFDAFNHPDIHGL 442

  Fly   440 FLQA----LAGVRIYLAKEEPGQEVVERGRKIYKRFEFLHRLLQFTLCGGAALILW 491
            .:|:    |..:|.:|.:|:|  :.:||.::|.:...||:|||:..|.  ..||||
  Fly   443 VIQSCSNMLHSIRTHLLREDP--KTLERSKRILRIKVFLYRLLRLFLL--YKLILW 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10096	NP_001027183.1	PLN02996	1..441	CDD:215538	126/455 (28%)
		FAR-N_SDR_e	12..330	CDD:187547	101/332 (30%)
		Sterile	363..453	CDD:281068	21/94 (22%)
FarO	NP_652021.1	FAR-N_SDR_e	18..328	CDD:187547	97/316 (31%)
FarO	NP_652021.1	FAR_C	379..>410	CDD:296071	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466747
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	8	7.840