DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10096 and Far2

DIOPT Version :9

Sequence 1:	NP_001027183.1	Gene:	CG10096 / 3772183	FlyBaseID:	FBgn0038032	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001334445.1	Gene:	Far2 / 330450	MGIID:	2687035	Length:	515	Species:	Mus musculus

Alignment Length:	493	Identity:	166/493 - (33%)
Similarity:	268/493 - (54%)	Gaps:	17/493 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VQSFYKDKTVFLTGGSGFLGKVTIAKLLCTT-EVKRIYVLLRAKRGQEMRERCAAWDKDPVFGNL 68
            :.:||.:|::.:||.:||||||.:.||..|: .:|.||:|:|.|.||.::||........:|..:
Mouse     4 IAAFYSNKSILITGATGFLGKVLMEKLFRTSPHLKVIYILVRPKSGQTLQERVFQILNSKLFEKV 68

  Fly    69 MKTNPEALKRVVPCGGDCQEPDLGLSNSDRQVLIDEVQIVIHTAATVRFVEPLHIALAVNTRATR 133
            .:..|...:::.|...|..:.|..:|..|.|.|:....|:.|.||||||...|..|:.:|..||:
Mouse    69 KEVCPNVHEKIRPISADLNQRDFAISKEDVQELLSCTNIIFHCAATVRFDAHLREAVQLNVTATQ 133

  Fly   134 LMIQLAKEMSHLESFVHVSTAYSNCVVEHVSERFYPEHLTCPAE--KILELLESISPELLDKMAP 196
            .::.:|.:|..||:|:|:|||:|||.:.|:.|..||    ||.|  ||::.:|.:...:::::.|
Mouse   134 QLLLMASQMPKLEAFIHISTAFSNCNLSHIDEVIYP----CPVEPRKIIDSMEWLDDSIIEEITP 194

  Fly   197 ALMGKYPNTYTYTKALTEQVIQKEAKDLPLSIFRPGVIIASYKEPMPGWIDNLYGPIAVLYGAAF 261
            .|:|..||||||||||.|.|:|:|:.:|.::|.||.::.|:::||.|||:|||.||..::.....
Mouse   195 KLIGDRPNTYTYTKALGEIVVQQESGNLNVAIVRPSIVGATWQEPFPGWVDNLNGPSGLIIATGK 259

  Fly   262 GILHITLLNLKAQAGIVPVDYCVNMVLTCAWNTARDTSIKLSPEPPIYNFTPNNDNLITWGGFRD 326
            |.|........|.|.::|||..||:.:...|.||    :.......||:.|..|.|...|.....
Mouse   260 GFLRSIKATPMAVADVIPVDTVVNLTIAVGWYTA----VHRPKSTLIYHSTSGNLNPCNWYKMGL 320

  Fly   327 KAARLRYTYPLTKMMWLPFLHCTTIPWLFRFTAIFYHLLPGYAIDLALRLWGKKPRMIKLYDKIH 391
            :........|.......|....||..:...:.....|.:|....|..|||.|:||||:||.:::.
Mouse   321 QVLATIEKIPFESAFRRPNADFTTSNFTTHYWNTVSHRVPAIIYDFYLRLTGRKPRMLKLMNRLL 385

  Fly   392 KNIDILAPFVITSWSFDTVNTRKLWAKMSVEDQKLYDFNMSSVDWDDYFLQALAGVRIYLAKEEP 456
            |.|.:|..|:..||.:.|.||..|.:::|.|||::::|::..::|.:|....:.||:.||.||:.
Mouse   386 KTISMLEYFINHSWEWSTNNTEMLLSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDL 450

  Fly   457 GQEVVERGRKIYKRFEFLHRLLQFTLCGGAALILWSIL 494
            ..  :.:.::..:|...:|.|....|    .||:|.:|
Mouse   451 AG--IPKAKQHLRRLRNIHYLFNTAL----FLIIWRLL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10096	NP_001027183.1	PLN02996	1..441	CDD:215538	152/438 (35%)
		FAR-N_SDR_e	12..330	CDD:187547	116/320 (36%)
		Sterile	363..453	CDD:281068	34/89 (38%)
Far2	NP_001334445.1	FAR-N_SDR_e	11..315	CDD:187547	115/311 (37%)
Far2	NP_001334445.1	Sterile	357..447	CDD:397244	34/89 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847922
Domainoid	1	1.000	96	1.000	Domainoid score	I7295
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840