DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sxl and HNRNPDL

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	NP_112740.1	Gene:	HNRNPDL / 9987	HGNCID:	5037	Length:	420	Species:	Homo sapiens

Alignment Length:	228	Identity:	54/228 - (23%)
Similarity:	92/228 - (40%)	Gaps:	31/228 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 PP------MASNNSLNNLCGLSLGS--GGSDDLMNDPRASNTNLIVNYLPQDMTDRELYALFRAI 140
            ||      |...|..:|:...:.||  ..|.:..:|.:     :.:..|..|.:.::|.......
Human   112 PPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDGK-----MFIGGLSWDTSKKDLTEYLSRF 171

  Fly   141 GPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKV----LNGITVRNKRLKVSYARPGGESIK 201
            |.:..|.|..|..||.|.|:.||.|.......:.:::    |:|..:..||.|   |..|.|..|
Human   172 GEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAK---ALKGKEPPK 233

  Fly   202 DTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNN 266
              .::|..|....:::|:...||.:|.|....:..|..|...||..|:.|...|..::.:.:..:
Human   234 --KVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYH 296

  Fly   267 VIPEGG-----SQPLSV----RLAEEHGKAKAA 290
            .|..|.     :||..|    :..::.|:..||
Human   297 QIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAA 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	20/83 (24%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	19/86 (22%)
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..120		2/7 (29%)
		RRM1_hnRPDL	149..224	CDD:410152	18/79 (23%)
		RRM2_hnRPDL	234..308	CDD:409998	16/73 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..348		4/17 (24%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269\|PubMed:9524220	342..420
		Necessary for its nuclear import and export	396..420
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910