DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sxl and SART3

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	XP_005269298.1	Gene:	SART3 / 9733	HGNCID:	16860	Length:	981	Species:	Homo sapiens

Alignment Length:	324	Identity:	70/324 - (21%)
Similarity:	128/324 - (39%)	Gaps:	69/324 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DTEFSFPSSSSRRGYNDFPGCGGSGGNGGSANNLGGGNMCHL----PPMASNNSLNNLCGLSLGS 102
            |.|...| |..||..|..|..|.:.....:|   |....|..    ||........:|      .
Human   653 DDEEEQP-SKRRRVENSIPAAGETQNVEVAA---GPAGKCAAVDVEPPSKQKEKAASL------K 707

  Fly   103 GGSDDLMNDPRASNTNLIVNYLPQDM--TDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDF 165
            .....:::|....:..:.|:.||..|  .|.:|..||.|.|.:...|.:...:..:. ||.:|:|
Human   708 RDMPKVLHDSSKDSITVFVSNLPYSMQEPDTKLRPLFEACGEVVQIRPIFSNRGDFR-GYCYVEF 771

  Fly   166 TSEMDSQRAI----KVLNGITV---------RNKRLKV-SYARPGGESIKDTNLYVTNLPRTITD 216
            ..|..:.:|:    |.:.|..:         :|...|| .|:    .|::...|:::.||.:.|.
Human   772 KEEKSALQALEMDRKSVEGRPMFVSPCVDKSKNPDFKVFRYS----TSLEKHKLFISGLPFSCTK 832

  Fly   217 DQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALN------NVIPEGGSQP 275
            ::|:.|...:|::....::.:: .|:|:|:|:|.|....:|.:|:..::      |:|....|.|
Human   833 EELEEICKAHGTVKDLRLVTNR-AGKPKGLAYVEYENESQASQAVMKMDGMTIKENIIKVAISNP 896

  Fly   276 LSVRLAEE-------------------HGKAKAAHFMSQMGVVPANVPPP---PPQPPAHMAAA 317
            ...::.|:                   .||.:     :|:.::|..:..|   .||.....|||
Human   897 PQRKVPEKPETRKAPGGPMLLPQTYGARGKGR-----TQLSLLPRALQRPSAAAPQAENGPAAA 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	23/95 (24%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	19/83 (23%)
SART3	XP_005269298.1	RNA14	100..>478	CDD:227438
		NRDE-2	351..>504	CDD:285605
		RRM	654..876	CDD:223796	53/237 (22%)
		RRM1_SART3	723..796	CDD:240837	19/73 (26%)
		RRM2_SART3	817..897	CDD:240838	18/80 (23%)
		LSM_int_assoc	895..951	CDD:293211	9/60 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910