DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sxl and GBP2

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	NP_009916.1	Gene:	GBP2 / 850346	SGDID:	S000000517	Length:	427	Species:	Saccharomyces cerevisiae

Alignment Length:	325	Identity:	77/325 - (23%)
Similarity:	116/325 - (35%)	Gaps:	85/325 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGN-----------------------NNPGSNNNNGGYPPYGYNNKSSGGRGFGMSHSLPSGMD 42
            ||||                       |:..|||.||       :.:....||        |..:
Yeast     7 MYGNDRSRSRSPVRRRLSDDRDRYDDYNDSSSNNGNG-------SRRQRRDRG--------SRFN 56

  Fly    43 TEFSFPSSSSRRGYND---FPGCGGSGGNGGSAN---NLGGGNMCHLPPMASNNSLNNLCGLSLG 101
            ..:......||  |:|   :|...|..|.|||.:   ..|||.                 |.:||
Yeast    57 DRYDQSYGGSR--YHDDRNWPPRRGGRGRGGSRSFRGGRGGGR-----------------GRTLG 102

  Fly   102 SGGSDDLMNDPRASNTN----LIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAF 162
            .....||.....|:..|    :.|..|..|.|..:|..||..:|.:....|:.  ..|:..|...
Yeast   103 PIVERDLERQFDATKRNFENSIFVRNLTFDCTPEDLKELFGTVGEVVEADIIT--SKGHHRGMGT 165

  Fly   163 VDFTSEMDSQRAIKVLNGITVRNKRLKVSYARPGGESIKDTN-------------LYVTNLPRTI 214
            |:||.....|.||...:|....:::|.|....|..|:.|:.:             :::.|||.::
Yeast   166 VEFTKNESVQDAISKFDGALFMDRKLMVRQDNPPPEAAKEFSKKATREEIDNGFEVFIINLPYSM 230

  Fly   215 TDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVR 279
            ....|..:|.:.|.:::.::..| ..|..||...|.|...:|...||...|.:..||  :.|.||
Yeast   231 NWQSLKDMFKECGHVLRADVELD-FNGFSRGFGSVIYPTEDEMIRAIDTFNGMEVEG--RVLEVR 292

Fly 280 279
Yeast 293 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	22/83 (27%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	21/90 (23%)
GBP2	NP_009916.1	RRM1_HRB1_GBP2	121..197	CDD:410184	20/77 (26%)
		RRM2_HRB1_GBP2	218..292	CDD:410185	19/76 (25%)
		RRM3_HRB1_GBP2	347..425	CDD:410186
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	76	1.000	Inparanoid score	I1646
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.920