DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sxl and PAB7

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	NP_181204.1	Gene:	PAB7 / 818238	AraportID:	AT2G36660	Length:	609	Species:	Arabidopsis thaliana

Alignment Length:	560	Identity:	137/560 - (24%)
Similarity:	213/560 - (38%)	Gaps:	121/560 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SSGGRGFGMSHSLPSG-----------MDTEFSFPSSSSRRGYNDFPGCGGSGGNG---GSANNL 75
            ||.|....::.||..|           .|....|.|.:|.|...|     .|.|..   |.||.|
plant    14 SSSGSSSPVTASLYVGDLHPSVTEGILYDAFAEFKSLTSVRLCKD-----ASSGRSLCYGYANFL 73

  Fly    76 GGGNMCHLPPMASNNSLNNLCGLSLGSGGSDDLMNDPRASNT------NLIVNYLPQDMTDRELY 134
            ...: .:|.....||||.|        |....:|...||.:.      |:.|..||:.:|:..|.
plant    74 SRQD-ANLAIEKKNNSLLN--------GKMIRVMWSVRAPDARRNGVGNVFVKNLPESVTNAVLQ 129

  Fly   135 ALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKVLNGITVRNKRLKVSYARPGGES 199
            .:|:..|.|.:|:: ...:.|.|.||.||.|..|..:..||:.||...|.:|.:.|.......:.
plant   130 DMFKKFGNIVSCKV-ATLEDGKSRGYGFVQFEQEDAAHAAIQTLNSTIVADKEIYVGKFMKKTDR 193

  Fly   200 IKD----TNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEA 260
            :|.    ||||:.||...:::|.|...|.::|.||...|.:|: ....||.|||.::..|:|:.|
plant   194 VKPEEKYTNLYMKNLDADVSEDLLREKFAEFGKIVSLAIAKDE-NRLCRGYAFVNFDNPEDARRA 257

  Fly   261 ISALNNVIPEGGSQPLSV---------------RLAEEHGKAKAAHFMSQMGVVPANVPPPPPQP 310
            ...:|..  :.||:.|.|               :..|:|.:.|....:|.:.|...||.....:.
plant   258 AETVNGT--KFGSKCLYVGRAQKKAEREQLLREQFKEKHEEQKMIAKVSNIYVKNVNVAVTEEEL 320

  Fly   311 PAHMAAAFNMMHRDGAMEKLRSLFDAICDAI-----FGL----DSENFADLLDGLYRRKYHYP-- 364
            ..|.:..       |.:...:    .:||..     ||.    ..|...|.:...:.:.:|..
plant   321 RKHFSQC-------GTITSTK----LMCDEKGKSKGFGFVCFSTPEEAIDAVKTFHGQMFHGKPL 374

  Fly   365 YLXLTPQQQQQLLQHQQQ----ALGFTSSSNNSIGNGNGNDNNMLLYHQQYHQQQT-QQQRLGNV 424
            |: :..:::.:.:|.|.|    .....|||:.|:..|    ....||:...|.... |...|...
plant   375 YVAIAQKKEDRKMQLQVQFGNRVEARKSSSSASVNPG----TYAPLYYTNTHPGMVYQSYPLMWK 435

  Fly   425 AAHNISPNGSNNNINT-----SNTNNINFNTIRQNGVA-----ALHYLQEQLQLQQPQDQQSQQQ 479
            :|:.|..:..|:...|     :|..:.|    |||.:.     |:.|:        |...||.|.
plant   436 SANMIGSSYPNSEAVTYPPMVANAPSKN----RQNRIGKLDRNAVSYV--------PNVYQSTQM 488

  Fly   480 QPLTMPSSPPFQQQSR---------QSHHNGSSSTLGNQL 510
            .||:...|.  ||.||         :|.....|.|:|.::
plant   489 LPLSRDFSK--QQHSRTYGRGKEMKKSIQQRQSETVGMEM 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	25/85 (29%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	27/92 (29%)
PAB7	NP_181204.1	PABP-1234	24..582	CDD:130689	134/550 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000313
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910