Protein Alignment Sxl and Pspc1

DIOPT Version :9

• Sequence 1: NP_001259303.1
• Gene: Sxl / 3772180
• FlyBaseID: FBgn0264270
• Length: 722
• Species: Drosophila melanogaster
• Sequence 2: NP_079958.3
• Gene: Pspc1 / 66645
• MGIID: 1913895
• Length: 523
• Species: Mus musculus
• Alignment Length: 528
• Identity: 105/528 - (19%)
• Similarity: 185/528 - (35%)
• Gaps: 130/528 - (24%)

  Fly   119 LIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKVLNGITV 183
            |.|..||.|:|:.:...||...|..:...|.||.      |:.|:...|...::.|...|:|..:
Mouse    83 LFVGNLPTDITEEDFKRLFERYGEPSEVFINRDR------GFGFIRLESRTLAEIAKAELDGTIL 141

  Fly   184 RNKRLKVSYARPGGESIKDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAF 248
            :::.|::.:|..|..      |.|.||...::::.|:..|.::|.:.:..::.|. .||..|..|
Mouse   142 KSRPLRIRFATHGAA------LTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDD-RGRATGKGF 199

  Fly   249 VRYNKREEAQEAISALNN-----------VIPEGGSQPLSVRLAEEHGKAKAAHFMSQMGVVPAN 302
            |.:..:..|::|:....:           ||.|    |:. :..:|.|..:.....:|.......
Mouse   200 VEFAAKPPARKALERCGDGAFLLTTTPRPVIVE----PME-QFDDEDGLPEKLMQKTQQYHKERE 259

  Fly   303 VPPPPPQPPAHMAAAFNMMHRDGAMEKL----RSLFDA-ICDAIFGLDSENFADLLDGLYRRKYH 362
            .||...||...   .|....|..|::::    |...|. |.:|...|::|..|       .|..|
Mouse   260 QPPRFAQPGTF---EFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEA-------ARHEH 314

  Fly   363 YPYLXLTPQQQQQLLQHQQQALGFTSSSNNSIGNGNGNDNNMLLYHQQYHQQQTQQQRLGNVAAH 427
            ...|     .:|.|::.|::........|..:    .....:.|.|::.|:::.::.
Mouse   315 QLML-----MRQDLMRRQEELRRLEELRNQEL----QKRKQIQLRHEEEHRRREEEM-------- 362

  Fly   428 NISPNGSNNNINTSNTNNINFNTIRQNGVAALHYLQEQLQLQQ-----PQDQQSQQQQPLTMPSS 487
                                   ||       |..||:|:.||     |...::::|: :.|...
Mouse   363 -----------------------IR-------HREQEELRRQQEGGFKPNYMENREQE-MRMGDM 396

  Fly   488 PPFQQQSRQSHHNG---SSSTLGNQ----LLAISNNNSFNNNSNQSNSFTGNYSNGSA------F 539
            .|     |.:.:.|   |.:..|.|    ::.::.||..................|:|      .
Mouse   397 GP-----RGAINMGDAFSPAPAGTQGPPPMMGMNMNNRGTIPGPPMGPGPAMGPEGAANMGTPMI 456

  Fly   540 TSNGAISGSNFPNNPTSSGNFTNNSTNSNPTNSGHFASNLAGSSNFTNHLSGSNNYTNSNGNFTS 604
            ..|||:....||..|              |:..|....|..||......:||....:...|.| .
Mouse   457 PDNGAVHNDRFPQGP--------------PSQMGSPMGNRTGSETPQAPMSGVGPVSGGPGGF-G 506

  Fly   605 NAASSSNF 612
            ..:...||
Mouse   507 RGSQGGNF 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	20/77 (26%)
		RRM2_Hu_like	203..281	CDD:240822	19/88 (22%)
Pspc1	NP_079958.3	RRM1_PSP1	80..150	CDD:241030	19/72 (26%)
		Sufficient for paraspeckles localization. /evidence=ECO:0000250	124..357		53/263 (20%)
		RRM2_PSP1	156..235	CDD:241033	19/89 (21%)
		NOPS_PSPC1	226..319	CDD:240584	24/112 (21%)
		Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000250	230..357		30/150 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	460..523		16/70 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910