Protein Alignment Sxl and SRSF1

DIOPT Version :9

• Sequence 1: NP_001259303.1
• Gene: Sxl / 3772180
• FlyBaseID: FBgn0264270
• Length: 722
• Species: Drosophila melanogaster
• Sequence 2: NP_008855.1
• Gene: SRSF1 / 6426
• HGNCID: 10780
• Length: 248
• Species: Homo sapiens
• Alignment Length: 218
• Identity: 43/218 - (19%)
• Similarity: 90/218 - (41%)
• Gaps: 42/218 - (19%)

  Fly   102 SGGSDDLMNDPRASN-TNLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDF 165
            |||.  ::..|..:| ..:.|..||.|:..:::..:|...|.|.... :::.:.|..|  |||:|
Human     2 SGGG--VIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDID-LKNRRGGPPF--AFVEF 61

  Fly   166 TSEMDSQRAIKVLNGITVRNKRLKVSYARPGGESIK----------------------DTNLYVT 208
            ....|::.|:...:|......||:|.:.|.|..:.:                      :..:.|:
Human    62 EDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSENRVVVS 126

  Fly   209 NLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNV---IPE 270
            .||.:.:...|.....:.|.:...::.||       |...|.:.::|:...|:..|:|.   ..|
Human   127 GLPPSGSWQDLKDHMREAGDVCYADVYRD-------GTGVVEFVRKEDMTYAVRKLDNTKFRSHE 184

  Fly   271 GGSQPLSVRL----AEEHGKAKA 289
            |.:..:.|::    :..:|::::
Human   185 GETAYIRVKVDGPRSPSYGRSRS 207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	20/79 (25%)
		RRM2_Hu_like	203..281	CDD:240822	16/84 (19%)
SRSF1	NP_008855.1	RRM1_SRSF1	12..90	CDD:410010	20/80 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		5/45 (11%)
		RRM2_SRSF1	113..196	CDD:410160	16/89 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..248		2/17 (12%)
		Interaction with SAFB1	198..247		1/10 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910