DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sxl and SFPQ

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	NP_005057.1	Gene:	SFPQ / 6421	HGNCID:	10774	Length:	707	Species:	Homo sapiens

Alignment Length:	620	Identity:	111/620 - (17%)
Similarity:	197/620 - (31%)	Gaps:	204/620 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PGSNNNNGGYPPYGYNNKSSGGRGFGMSHSLPSGMDTEFSFPSSSSRRGYNDFPGCGGSGGNGGS 71
            ||.....||..|.|  .|..||                   |..|:..|:...|..||....||.
Human   202 PGPGGPKGGKMPGG--PKPGGG-------------------PGLSTPGGHPKPPHRGGGEPRGGR 245

  Fly    72 ANNLGGGNMCHLPPMASNNSLNNLCGLSLGSGG-SDDLMNDPRASNTN----------------- 118
            .         |.||....:......|   |.|| |::.::|......|
Human   246 Q---------HHPPYHQQHHQGPPPG---GPGGRSEEKISDSEGFKANLSLLRRPGEKTYTQRCR 298

  Fly   119 LIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSF-----GYAFVDFTSEMDSQRAIKVL 178
            |.|..||.|:|:.|...||...|           :.|..|     |:.|:...|...::.|...|
Human   299 LFVGNLPADITEDEFKRLFAKYG-----------EPGEVFINKGKGFGFIKLESRALAEIAKAEL 352

  Fly   179 NGITVRNKRLKVSYARPGGESIKDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRP 243
            :...:|.::|:|.:|.....      |.|.||...::::.|:..|.::|.|.:..::.|. .||.
Human   353 DDTPMRGRQLRVRFATHAAA------LSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDD-RGRS 410

  Fly   244 RGVAFVRYNKREEAQEAISALNN-----------VIPEGGSQPLSVRLAEEHGKAKAAHFMSQMG 297
            .|...|.:..:..|::|....:.           ||.|    ||. :|.:|.|..:.   ::|..
Human   411 TGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVIVE----PLE-QLDDEDGLPEK---LAQKN 467

  Fly   298 VVPANVPPPPPQPPAHMAAAFNMMHRDGAMEKL---------RSLFDAICDAIFGLDSENFADLL 353
            .:.......||:...|....:....|..:::::         :::.||             .|.|
Human   468 PMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDA-------------KDKL 519

  Fly   354 DGLYRRKYHYPYLXLTPQQQQQLLQHQQQALGFTSSSNNSIGNGNGNDNNMLLYHQQYHQQQTQQ 418
            :......||.... |.   :|.|::.|::                      |...::.|.|:.|:
Human   520 ESEMEDAYHEHQANLL---RQDLMRRQEE----------------------LRRMEELHNQEMQK 559

  Fly   419 QRLGNVAAHNISPNGSNNNINTSNTNNINFNTIRQNGVAALHYLQEQLQLQQPQDQQSQQQQPLT 483
            ::                                            ::||:|.::::.::::  .
Human   560 RK--------------------------------------------EMQLRQEEERRRREEE--M 578

  Fly   484 MPSSPPFQQQSRQSHHNGSSSTLG-----NQLLAISNNNSFNNNSNQSNSFTGNYSNGSAFTSNG 543
            |......::|.|:.... |.|.:|     .:.:.:....:.|......       |.|..|...|
Human   579 MIRQREMEEQMRRQREE-SYSRMGYMDPRERDMRMGGGGAMNMGDPYG-------SGGQKFPPLG 635

  Fly   544 AISGSNFPNNP-----TSSGNFTNNSTNSNPTNSG 573
            ...|..:..||     |.||:...:...:.....|
Human   636 GGGGIGYEANPGVPPATMSGSMMGSDMRTERFGQG 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	22/101 (22%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	20/88 (23%)
SFPQ	NP_005057.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..273		25/103 (24%)
		3 X 3 AA repeats of R-G-G	9..27
		RRM1_PSF	296..366	CDD:241031	20/80 (25%)
		RRM2_p54nrb_like	372..451	CDD:240779	19/89 (21%)
		NOPS_PSF	442..538	CDD:240583	20/119 (17%)
		PTZ00121	<499..>599	CDD:173412	21/184 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..707		18/100 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910