DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sxl and Rbms2

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	NP_062685.2	Gene:	Rbms2 / 56516	MGIID:	1861776	Length:	383	Species:	Mus musculus

Alignment Length:	293	Identity:	81/293 - (27%)
Similarity:	125/293 - (42%)	Gaps:	43/293 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SSSSRRGYNDFPGCGGSGGNGGSANNLGGGNMCHLPPMASNNSLNNLCGLSLGSGGSDDLMNDPR 113
            |.:||.|.:.|      |.|..:........|.  ||...|::.|:..|...||||:|.|
Mouse     4 SVTSRPGISTF------GYNKNNKKLYVAQQMA--PPSPRNSTPNSSGGGGGGSGGNDQL----- 55

  Fly   114 ASNTNLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKVL 178
             |.|||.:..|....||::|..|.:..|.|.:.:.:.|..|....||.||||.|...:|:|:..|
Mouse    56 -SKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPSSAQKAVTAL 119

  Fly   179 NGITVRNKRLKVSYARPGGESIKDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRP 243
            ....|:.:..|.....|       ||||::|||.::.:.:|:.:...:|.::...|||| .:|..
Mouse   120 KASGVQAQMAKQQEQDP-------TNLYISNLPLSMDEQELEGMLKPFGQVISTRILRD-TSGAS 176

  Fly   244 RGVAFVRYNKREEAQEAISALNN---VIPEG---GSQPLSVRLAE-------------EHGKAKA 289
            |||.|.|....|:.:..|:..|.   ..|.|   .|.||..:.|:             ::|:|..
Mouse   177 RGVGFARMESTEKCEAIITHFNGKYIKTPPGVAAPSDPLLCKFADGGPKKRQSQGRYVQNGRAWP 241

  Fly   290 AHFMSQMGVVPANVPPPPPQPPAHMAAAFNMMH 322
            .:  ..||.:.....|.........||.:::.|
Mouse   242 RN--GDMGGMALTYDPTAALQNGFYAAPYSIAH 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	25/79 (32%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	27/83 (33%)
Rbms2	NP_062685.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..56		12/35 (34%)
		RRM_SF	53..136	CDD:388407	27/88 (31%)
		RRM2_MSSP2	137..222	CDD:240918	28/85 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910