DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sxl and RAVER2

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	NP_001353094.1	Gene:	RAVER2 / 55225	HGNCID:	25577	Length:	691	Species:	Homo sapiens

Alignment Length:	722	Identity:	142/722 - (19%)
Similarity:	249/722 - (34%)	Gaps:	213/722 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GGSGGNG-GSANNLGGGNMCHLPPMASNNSLNNLCGLSLGSGGSDDL---------------MND 111
            ||.||.| |||..||.|     |.:.....     ......|..|.:               |..
Human     9 GGEGGAGLGSAAGLGPG-----PGLRGQGP-----SAEAHEGAPDPMPAALHPEEVAARLQRMQR 63

  Fly   112 PRASNTNLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIK 176
            ..::...::|..||||...:|::.|.:.. .:..|.:.|:.:|      |||...:...:|.||:
Human    64 ELSNRRKILVKNLPQDSNCQEVHDLLKDY-DLKYCYVDRNKRT------AFVTLLNGEQAQNAIQ 121

  Fly   177 VLNGITVRNKRLKVSYARPGGESIKDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTG 241
            :.:..:.|.|.|.|. .:|     .|..|.:||:|.:.|.::.:.:...||:|.:..::..::||
Human   122 MFHQYSFRGKDLIVQ-LQP-----TDALLCITNVPISFTSEEFEELVRAYGNIERCFLVYSEVTG 180

  Fly   242 RPRGVAFVRYNKREEAQEA-ISALNNVIPEGGSQPLSVR------LAEE--HGKAKAAHFMSQMG 297
            ..:|..||.|.|::.|.:| :..|...:   |:..|..:      ||.|  |.|...      :.
Human   181 HSKGYGFVEYMKKDFAAKARLELLGRQL---GASALFAQWMDVNLLASELIHSKCLC------ID 236

  Fly   298 VVPANVPPPPPQPPAHMAAAFNMMHRDGAMEKLRSLFDAICDAIFGLDSENFADLLDGLYRRKYH 362
            .:|::                   :||.  |:|..:|.::...:|...:::....:.|....:|.
Human   237 KLPSD-------------------YRDS--EELLQIFSSVHKPVFCQLAQDEGSYVGGFAVVEYS 280

  Fly   363 YPYLXLTPQQQQQLLQHQQQALGFTSSSN---------NSIGNG------------NGNDNNML- 405
                  |.:|.:::   ||.|.|.|...:         .:.|..            :.|...:|
Human   281 ------TAEQAEEV---QQAADGMTIKGSKVQVSFCAPGAPGRSTLAALIAAQRVMHSNQKGLLP 336

  Fly   406 ----------LYHQQYHQQQTQQQRLGNVA----------------------------AHNISPN 432
                      |.:....|...|.|..|...                            ||..|..
Human   337 EPNPVQIMKSLNNPAMLQVLLQPQLCGRAVKPAVLGTPHSLPHLMNPSISPAFLHLNKAHQSSVM 401

  Fly   433 GSNNNINTSNTNNI--------NFNTIRQNGVAALHYLQEQLQLQQPQDQQSQQQQPLTMPSSPP 489
            |:.:|:...|.::|        .|..|..|....|        |.:|  .....|..|.:.|..|
Human   402 GNTSNLFLQNLSHIPLAQQQLMKFENIHTNNKPGL--------LGEP--PAVVLQTALGIGSVLP 456

  Fly   490 FQQQSRQSHHNG------------SSSTLGNQLLAISNNNSFNNNSNQSNSFTGNYSNGSAFTSN 542
            .:::  ..||:|            ::.|.|..:|....|......:...:|.|......:...:.
Human   457 LKKE--LGHHHGEAHKTSSLIPTQTTITAGMGMLPFFPNQHIAGQAGPGHSNTQEKQPATVGMAE 519

  Fly   543 GAISGS-----NFPNNPTSSGNFT---NNSTNSNPTNSGHFASNLAGSSNFTNHLS--------G 591
            |..|||     :|||  .::|:..   :....|.|  .|...|:.|.|.|.|:.|.        .
Human   520 GNFSGSQPYLQSFPN--LAAGSLLVGHHKQQQSQP--KGTEISSGAASKNQTSLLGEPPKEIRLS 580

  Fly   592 SNNYTNSNGNFTSNAASSSNFSNNAASSTNYSKNCSSGVVGNSDPDSCSR----KHTTNTNNHHT 652
            .|.|.|     .::...|...|:.|:.:|.:....:|.::     |:.|:    :|.......::
Human   581 KNPYLN-----LASVLPSVCLSSPASKTTLHKTGIASSIL-----DAISQGSESQHALEKCIAYS 635

  Fly   653 SPQHDFS 659
            .|..|::
Human   636 PPFGDYA 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	21/79 (27%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	20/84 (24%)
RAVER2	NP_001353094.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		14/47 (30%)
		RRM1_RAVER2	70..139	CDD:241108	20/76 (26%)
		RRM2_RAVER2	143..219	CDD:241110	20/78 (26%)
		RRM3_RAVER2	229..326	CDD:241112	19/132 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..522		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..574		9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910