Protein Alignment Sxl and RBFOX1

DIOPT Version :9

• Sequence 1: NP_001259303.1
• Gene: Sxl / 3772180
• FlyBaseID: FBgn0264270
• Length: 722
• Species: Drosophila melanogaster
• Sequence 2: XP_016878807.1
• Gene: RBFOX1 / 54715
• HGNCID: 18222
• Length: 623
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 111/659 - (16%)
• Similarity: 187/659 - (28%)
• Gaps: 260/659 - (39%)

  Fly    20 GYNNKSSGGRGFGMSHSLPSGMDTEFSFP---SSSSRRGYNDFP------GCGGSGGN------- 68
            |.::..|.||..|...| |||.......|   ....||..:|.|      ..|..||:
Human    27 GPSSSPSAGRAPGAMAS-PSGSSEATGKPRGRDGRPRREEDDVPPEEKRLRLGLEGGSAQPEDCE 90

  Fly    69 -------------GGSANNLGGGNMCHLP-----------------PMASNNSLNNLCGLSLGSG 103
                         |......|.|::..||                 | .:.|||.:....|..:|
Human    91 DGKDAPRPGREETGTQTGGDGRGDLLCLPYSLVEGQDYKSENSTLLP-GAKNSLQDSVSASQATG 154

  Fly   104 GSDDLMNDPRASNTNLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTG------------- 155
            .:::......||.|        ....||..::..:|  ..|||..:.|.|..
Human   155 KAEETGQRTHASGT--------YSFLDRTQHSDIKA--DCNTCVEIEDRKVSRQQMNCEREQLRG 209

  Fly   156 ----------YSFGYAFVDF------------------------------------------TSE 168
                      .:..||...|                                          :.:
Human   210 NQEAAAAPDTMAQPYASAQFAPPQNGIPAEYTAPHPHPAPEYTGQTTVPEHTLNLYPPAQTHSEQ 274

  Fly   169 MDSQRAIKVLNGITVRNKRLKVSYARPGGESIKDT-------NLYVTNLPRTITDDQLDTIFGKY 226
            ..:..:.:.::|...:......:..:|..:..::|       .|:|:|:|....|..|..:||::
Human   275 SPADTSAQTVSGTATQTDDAAPTDGQPQTQPSENTENKSQPKRLHVSNIPFRFRDPDLRQMFGQF 339

  Fly   227 GSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGS------------------ 273
            |.|:...|:.::...  :|..||.:....:|..|...|:..:.||..
Human   340 GKILDVEIIFNERGS--KGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKTVN 402

  Fly   274 --------QPL------------SVRLAEEHGKAKAAHFMSQMGVVPANVPPPPPQPPAHMAAAF 318
                    .|:            :|.|.:.:.:. ::.:.:...:|..:..|..|.|.|..|||:
Human   403 PYTNGWKLNPVVGAVYSPEFYAGTVLLCQANQEG-SSMYSAPSSLVYTSAMPGFPYPAATAAAAY 466

  Fly   319 NMMHRDGAMEKLRSLFDAIC--------------DAIFGLDSENFADLLDGLYRRKYHYPYLXLT 369
            ...|..|....:.:.|.|..              :.::|      ..||.|.|..   |.|. .|
Human   467 RGAHLRGRGRTVYNTFRAAAPPPPIPAYGGVVYQEPVYG------NKLLQGGYAA---YRYAQPT 522

  Fly   370 PQQQQQLLQHQQQALGFTSSSNNSIGNGNGNDNNMLLYHQQYHQQQTQQQRLGNVAAHNISPNGS 434
            |.               |:::.        :|.|..::                |||..||.|.|
Human   523 PA---------------TAAAY--------SDRNQFVF----------------VAADEISCNTS 548

  Fly   435 NNNINTSNTNNINFNTIRQNGVAALHYLQEQLQL-----QQPQDQQSQQQQPLTMP--------- 485
                  :.|:.....|     ....|.||.....     :.|...|:.::...|:|
Human   549 ------AVTDEFMLPT-----PTTTHLLQPPPTALVPCPKVPAPAQTSEELSCTLPGLCCQAAEN 602

  Fly   486 --SSPPFQQ 492
              :|||..|
Human   603 LTASPPLLQ 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	14/144 (10%)
		RRM2_Hu_like	203..281	CDD:240822	22/122 (18%)
RBFOX1	XP_016878807.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910