DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sxl and NONO

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	NP_001138880.1	Gene:	NONO / 4841	HGNCID:	7871	Length:	471	Species:	Homo sapiens

Alignment Length:	421	Identity:	77/421 - (18%)
Similarity:	158/421 - (37%)	Gaps:	129/421 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 PPMASNNSLNNLCGLSLGSGGSDDLMNDPR------ASNTNLIVNYLPQDMTDRELYALFRAIGP 142
            ||:.:|....:    |...|.:.||.|..:      ...:.|.|..||.|:|:.|:..||...|.
Human    39 PPIPANGQQAS----SQNEGLTIDLKNFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGK 99

  Fly   143 INTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKVLNGITVRNKRLKVSYARPGGESIKDTNLYV 207
            .....|.:|.      |:.|:...:...::.|...|:.:.:|.|:|:|.:|      ....:|.|
Human   100 AGEVFIHKDK------GFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRFA------CHSASLTV 152

  Fly   208 TNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAI------SALNN 266
            .|||:.::::.|:..|..:|.:.:..::.|. .|||.|...|.::.:..|::|:      |.|..
Human   153 RNLPQYVSNELLEEAFSVFGQVERAVVIVDD-RGRPSGKGIVEFSGKPAARKALDRCSEGSFLLT 216

  Fly   267 VIPEGGSQPLSV----RLAEEHGKAKAAHFMSQMGVVPANVPPPPPQPPAHMAAAFNMMHRDGAM 327
            ..|    :|::|    :|.:|.|..:.....:|........||...||              |:.
Human   217 TFP----RPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQP--------------GSF 263

  Fly   328 EKLRSLFDAICDAIFGLDSENFADLLDGLYRRKYHY-----PYLXLTPQQQQQL---LQHQQQAL 384
            |                                |.|     ..: :..|||.|:   ::..::.|
Human   264 E--------------------------------YEYAMRWKALIEMEKQQQDQVDRNIKEAREKL 296

  Fly   385 GFTSSSNNSIGNGNGNDNNMLLYHQQYHQQQTQQQRLGNVAAHNISPNGSNNNINTSNTNNINFN 449
            .....:..       :::.::|..|...::|.:.:|:..:  ||                    .
Human   297 EMEMEAAR-------HEHQVMLMRQDLMRRQEELRRMEEL--HN--------------------Q 332

  Fly   450 TIRQNGVAALHYLQEQLQLQQPQDQQSQQQQ 480
            .:::         ::||:|:|.::::.::::
Human   333 EVQK---------RKQLELRQEEERRRREEE 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	21/79 (27%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	21/87 (24%)
NONO	NP_001138880.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		3/15 (20%)
		DBHS	54..373		73/402 (18%)
		RRM1_p54nrb	73..143	CDD:410001	20/75 (27%)
		RRM_SF	149..228	CDD:418427	21/83 (25%)
		NOPS_p54nrb_PSF_PSPC1	219..311	CDD:240581	20/148 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910