DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sxl and NCL

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	NP_005372.2	Gene:	NCL / 4691	HGNCID:	7667	Length:	710	Species:	Homo sapiens

Alignment Length:	328	Identity:	73/328 - (22%)
Similarity:	122/328 - (37%)	Gaps:	86/328 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GMDTEFSFPSSSSRRGYNDFPGCGGSGGNGGSANNLGGGNMCHLPPMASNNSLNNLCGLSLGSGG 104
            ||..:|         ||.||.          ||.:|              .....|.||.:  .|
Human   344 GMTRKF---------GYVDFE----------SAEDL--------------EKALELTGLKV--FG 373

  Fly   105 SDDLMNDPRASNT-------NLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAF 162
            ::..:..|:..::       .|:...||..:|..||..:|.....|   |::.  |.|.|.|.|:
Human   374 NEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEI---RLVS--KDGKSKGIAY 433

  Fly   163 VDFTSEMDSQRAIKVLNGITVRNKRLKVSYARPGGE------------SIKDTNLYVTNLPRTIT 215
            ::|.:|.|:::..:...|..:..:.:.:.|....|:            |.:...|.::||..:.|
Human   434 IEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSAT 498

  Fly   216 DDQLDTIFGKYGSI-VQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVR 279
            ::.|..:|.|...| |.:|     ..|:.:|.||:.:...|:|:||:::.|....||    .::|
Human   499 EETLQEVFEKATFIKVPQN-----QNGKSKGYAFIEFASFEDAKEALNSCNKREIEG----RAIR 554

  Fly   280 LAEEHGKAKAAHFMSQMGVVPANVPPPPPQPPAHMAAAFNMMHRDGAMEKLRSLFDAICDAIFGL 344
            | |..|              |...|....||...:..  ..:..|...|.|:..||....|....
Human   555 L-ELQG--------------PRGSPNARSQPSKTLFV--KGLSEDTTEETLKESFDGSVRARIVT 602

  Fly   345 DSE 347
            |.|
Human   603 DRE 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	19/86 (22%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	22/78 (28%)
NCL	NP_005372.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..303
		8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X	58..135
		RRM1_NCL	307..381	CDD:240849	14/71 (20%)
		RRM	379..628	CDD:223796	59/258 (23%)
		RRM2_NCL	390..465	CDD:240850	19/79 (24%)
		RRM3_NCL	485..557	CDD:240851	23/81 (28%)
		RRM4_NCL	572..649	CDD:240852	8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910