Protein Alignment Sxl and HNRNPL

DIOPT Version :9

• Sequence 1: NP_001259303.1
• Gene: Sxl / 3772180
• FlyBaseID: FBgn0264270
• Length: 722
• Species: Drosophila melanogaster
• Sequence 2: NP_001372580.1
• Gene: HNRNPL / 3191
• HGNCID: 5045
• Length: 626
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 117/607 - (19%)
• Similarity: 191/607 - (31%)
• Gaps: 183/607 - (30%)

  Fly     8 GSNNNNGGYPPYGYNNKSSGGRGFGMSHSLPSGMDTEFSFPSSSSRRGYNDFPGCGGSGGNGGSA 72
            |.....|.|    |...|.|||.       |..:.|:    ::..:.|     |.||.||..|:|
Human    39 GGGGGGGRY----YGGGSEGGRA-------PKRLKTD----NAGDQHG-----GGGGGGGGAGAA 83

  Fly    73 NNLGGG----------------------------------------------------------- 78
            ...|||
Human    84 GGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVL 148

  Fly    79 NMCHLPPMASNNSL---------NNLCGLSLGSGGSDDLMNDPRASNTNLIVNYLP--QDMTDRE 132
            ..|:....|::|.:         |......:...|..|   |.|:.|:.|:...|.  ..:|...
Human   149 GACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSD---DSRSVNSVLLFTILNPIYSITTDV 210

  Fly   133 LYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKVLNGITVRNK--RLKVSYARP 195
            ||.:....||:....|.|  |.|..   |.|:|.|...:|||...|||..:.:.  .||:.||:|
Human   211 LYTICNPCGPVQRIVIFR--KNGVQ---AMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKP 270

  Fly   196 GGESIKDTNLYVTNLPRTITDDQLDTIFGK--YGSIVQKNILRDKLTG-RP----RGVAFVRYNK 253
                   |.|.|....:...|.....:.|:  .||...|...:..|.| .|    .|..|...:.
Human   271 -------TRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGEGRGFPSVDS 328

  Fly   254 R---EEAQEAISALNNVIPEGGSQPLSVRLAEEHGKAKAAHFMSQMGVVPANV------------ 303
            |   ..|:......:.|:|...|.|    ....||...:.:.....|..|.:.
Human   329 RGSCAPARRPPCKFSPVLPLFPSHP----PGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGH 389

  Fly   304 -------------PPPPPQPPAHMAAAFNMMHRDGAMEKLRSLFDA--ICDAIFGLDSENFADLL 353
                         |||||.||.:..      |.|..:..:..|..:  .||.:|     |...|.
Human   390 RRGPSRYGPQYGHPPPPPPPPEYGP------HADSPVLMVYGLDQSKMNCDRVF-----NVFCLY 443

  Fly   354 DGLYRRKYHYPYLXLTPQQQQQLLQHQQQALGFTSSSNNSIGNGNGNDNNMLLYHQQYHQQQTQQ 418
            ..:.:.|:               ::.:..|.....:...::.....:.||..::.|:.:...::|
Human   444 GNVEKVKF---------------MKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQ 493

  Fly   419 QRLGNVAAHNISPNGSNNNINTSNTNNINFNTIRQ---NGVA----ALHYLQEQLQLQQPQDQQS 476
            ..:....::.:. :||.:..:.|.:.|..|:|..|   |.:.    .||:....|::.:....:.
Human   494 PAIMPGQSYGLE-DGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEI 557

  Fly   477 QQQQPLTMPSS-PPFQQQSRQS 497
            ..:..:..||| ..|..:|.:|
Human   558 CDELGVKRPSSVKVFSGKSERS 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	26/83 (31%)
		RRM2_Hu_like	203..281	CDD:240822	19/87 (22%)
HNRNPL	NP_001372580.1	hnRNP-L_PTB	100..624	CDD:273733	96/526 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910