Protein Alignment Sxl and HNRNPA1

DIOPT Version :9

• Sequence 1: NP_001259303.1
• Gene: Sxl / 3772180
• FlyBaseID: FBgn0264270
• Length: 722
• Species: Drosophila melanogaster
• Sequence 2: NP_112420.1
• Gene: HNRNPA1 / 3178
• HGNCID: 5031
• Length: 372
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 101/519 - (19%)
• Similarity: 158/519 - (30%)
• Gaps: 196/519 - (37%)

  Fly   119 LIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTS--EMD---SQRAIKVL 178
            |.:..|..:.||..|.:.|...|.:..|.:|||..|..|.|:.||.:.:  |:|   :.|..||
Human    16 LFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKV- 79

  Fly   179 NGITVRNKRL--KVSYARPGGE-SIKDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLT 240
            :|..|..||.  :....|||.. ::|  .::|..:.....:..|...|.:||.|....|:.|:.:
Human    80 DGRVVEPKRAVSREDSQRPGAHLTVK--KIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGS 142

  Fly   241 GRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVRLAEEHGKAKAAHFMSQMGVVPANVPP 305
            |:.||.|||.:                              ::|
Human   143 GKKRGFAFVTF------------------------------DDH--------------------- 156

  Fly   306 PPPQPPAHMAAAFNMMHRDGAMEKLRSLFDAICDAIFGLDSENFADLLDGLYRRKYHYPYLXLTP 370
                                                         |.:|.:..:|||      |.
Human   157 ---------------------------------------------DSVDKIVIQKYH------TV 170

  Fly   371 Q----QQQQLLQHQQQALGFTSSSNNSIGNGN----------GNDNNMLLYHQQYHQQQTQQQRL 421
            .    :.::.|..|:.| ..:||.....|:||          ||||               ..|.
Human   171 NGHNCEVRKALSKQEMA-SASSSQRGRSGSGNFGGGRGGGFGGNDN---------------FGRG 219

  Fly   422 GNVAAHNISPNGSNNNINTSNTNNINFNTIRQNGVAALHYLQEQLQLQQPQDQQSQQQQPLTMPS 486
            ||.:... ...||........:.: .:|....:|...                          ..
Human   220 GNFSGRG-GFGGSRGGGGYGGSGD-GYNGFGNDGGYG--------------------------GG 256

  Fly   487 SPPFQQQSRQSHHNGSSSTLGNQLLAISNNNSFNNNSNQSNSFTGNYSNGSAFTSNGAISGSNFP 551
            .|.:...||.....|..  .|||......:.|:::.:|         ..|..|   |..|||||.
Human   257 GPGYSGGSRGYGSGGQG--YGNQGSGYGGSGSYDSYNN---------GGGGGF---GGGSGSNFG 307

  Fly   552 NNPTSS--GNFTNNSTNSNPTNSGHFASNLAGSSNFTNHLSGSNNY---TNSNGNFTSNAASSS 610
            ...:.:  ||:.|.|:|..|...|:|....:|.      ..|...|   ..:.|.:..:::|||
Human   308 GGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGP------YGGGGQYFAKPRNQGGYGGSSSSSS 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	27/84 (32%)
		RRM2_Hu_like	203..281	CDD:240822	14/77 (18%)
HNRNPA1	NP_112420.1	Globular A domain	4..94		25/78 (32%)
		RRM1_hnRNPA1	12..92	CDD:410154	25/76 (33%)
		Globular B domain	95..185		26/193 (13%)
		RRM2_hnRNPA3	105..184	CDD:409996	23/182 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..216		11/49 (22%)
		RNA-binding RGG-box	218..240		5/22 (23%)
		HnRNPA1	307..344	CDD:402981	9/42 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..372		14/55 (25%)
		Nuclear targeting sequence (M9)	320..357		10/42 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920