DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sxl and Pspc1

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	NP_001020843.1	Gene:	Pspc1 / 305910	RGDID:	1310122	Length:	522	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	105/513 - (20%)
Similarity:	184/513 - (35%)	Gaps:	121/513 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKVLNGITV 183
            |.|..||.|:|:.:...||...|..:...|.||.      |:.|:...|...::.|...|:|..:
  Rat    83 LFVGNLPTDITEEDFKRLFERYGEPSEVFINRDR------GFGFIRLESRTLAEIAKAELDGTIL 141

  Fly   184 RNKRLKVSYARPGGESIKDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAF 248
            :::.|::.:|..|..      |.|.||...::::.|:..|.::|.:.:..::.|. .||..|..|
  Rat   142 KSRPLRIRFATHGAA------LTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDD-RGRATGKGF 199

  Fly   249 VRYNKREEAQEAISALNN-----------VIPEGGSQPLSVRLAEEHGKAKAAHFMSQMGVVPAN 302
            |.:..:..|::|:....:           ||.|    |:. :..:|.|..:.....:|.......
  Rat   200 VEFAAKPPARKALERCGDGAFLLTTTPRPVIVE----PME-QFDDEDGLPEKLMQKTQQYHKERE 259

  Fly   303 VPPPPPQPPAHMAAAFNMMHRDGAMEKL----RSLFDA-ICDAIFGLDSENFADLLDGLYRRKYH 362
            .||...||...   .|....|..|::::    |...|. |.:|...|::|..|       .|..|
  Rat   260 QPPRFAQPGTF---EFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEA-------ARHEH 314

  Fly   363 YPYLXLTPQQQQQLLQHQQQALGFTSSSNNSIGNGNGNDNNMLLYHQQYHQQQTQQQRLGNVAAH 427
            ...|     .:|.|::.|::........|..:    .....:.|.|::.|:::.::.
  Rat   315 QLML-----MRQDLMRRQEELRRLEELRNQEL----QKRKQIQLRHEEEHRRREEEM-------- 362

  Fly   428 NISPNGSNNNINTSNTNNINFNTIRQNGVAALHYLQEQLQLQQ----PQDQQSQQQQPLTMPSSP 488
                                   ||       |..||:|:.||    |...::::|: :.|....
  Rat   363 -----------------------IR-------HREQEELRRQQEGFKPNYMENREQE-MRMGDMG 396

  Fly   489 PFQQQSRQSHHNG---SSSTLGNQ----LLAISNNNSFNNNSNQSNSFTGNYSNGSA------FT 540
            |     |.:.:.|   |.:..|.|    ::.::.||..................|:|      ..
  Rat   397 P-----RGAINMGDAFSPAPAGTQGPPPMMGMNMNNRGTIPGPPMGPGPAMGPEGAANMGTPMIP 456

  Fly   541 SNGAISGSNFPNNPTSS-----GNFTNNSTNSNPTNSGHFASNLAGSSNFTNHLSGSN 593
            .|||:....||..|.|.     ||.|.:.|...|.::....|  .|...|.....|.|
  Rat   457 DNGAVHNDRFPQGPPSQMGSPMGNRTGSETPQAPMSAVGPVS--GGPGGFGRGSQGGN 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	20/77 (26%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	19/88 (22%)
Pspc1	NP_001020843.1	RRM1_PSP1	80..150	CDD:241030	19/72 (26%)
		Sufficient for paraspeckles localization. /evidence=ECO:0000250	124..357		53/263 (20%)
		RRM2_PSP1	156..235	CDD:241033	19/89 (21%)
		NOPS_PSPC1	226..319	CDD:240584	24/112 (21%)
		Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000250	230..357		30/150 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..522		16/56 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910