DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sxl and Rbms2

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	XP_006240804.1	Gene:	Rbms2 / 288771	RGDID:	1304813	Length:	405	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	118/513 - (23%)
Similarity:	180/513 - (35%)	Gaps:	145/513 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SSSSRRGYNDFPGCGGSGGNGGSANNLGGGNMCHLPPMASNNSLNNLCGLSLGSGGSDDLMNDPR 113
            |.:||.|.:.|      |.|..:........|.  ||...|.:.|:    |.||||:|.|
  Rat     4 SVTSRPGISTF------GYNKNNKKLYVAQQMA--PPSPRNGTPNS----SSGSGGNDQL----- 51

  Fly   114 ASNTNLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKVL 178
             |.|||.:..|....||::|..|.:..|.|.:.:.:.|..|....||.||||.|...:|:|:..|
  Rat    52 -SKTNLYIRGLQPSTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPSSAQKAVTAL 115

  Fly   179 NGITVRNKRLKVSYARPGGESIKDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRP 243
            ....|:.:..|.....|       ||||::|||.::.:.:|:.:...:|.::...|||| .||..
  Rat   116 KASGVQAQMAKQQEQDP-------TNLYISNLPLSMDEQELEGMLKPFGQVISTRILRD-TTGAS 172

  Fly   244 RGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVRLAEEHGKAKAAHFMSQMGVVPANVPPPPP 308
            |||.|.|....|:.:..|:                            ||..:....|..|..|..
  Rat   173 RGVGFARMESTEKCEAIIT----------------------------HFNGKYIKTPPGVAAPSD 209

  Fly   309 QPPAHMAAAFNMMHRDGAMEKLRSLFDAICDAIFGLDSENFADLLDGLYRRKYHYPYLXLTPQQQ 373
                                      ..:|         .|||  .|..:|           |.|
  Rat   210 --------------------------PLLC---------KFAD--GGPKKR-----------QNQ 226

  Fly   374 QQLLQHQQQALGFTSSSNNSIGNGNGNDNNMLLYHQQYHQQQTQQQRLGNVAAHNISPNGSNNNI 438
            .:.:|            |......||:...|.|.:......|                    |..
  Rat   227 GKFVQ------------NGRAWPRNGDMGGMALTYDPTTALQ--------------------NGF 259

  Fly   439 NTSNTNNINFNTIRQNGVAALHYLQEQLQLQQPQDQQSQQQQPLTMPSSPPFQQQSRQSHHNGSS 503
            .|:..:..:...:.|:.:|.  ||...:...|...|.|    |:.:|::...||||.....:||.
  Rat   260 YTAPYSLAHSRMLAQSALAP--YLPSPVSSYQRVTQTS----PVQVPNTSWMQQQSYLMQPSGSV 318

  Fly   504 STLG-NQLLAISNNNSFNNNSNQSNSFTGNYSNGSAFTSNGAISG---SNFPNNPTSS 557
            .|.| :..|::...:.....:.|....:.| |.|:...:..|:.|   |.:|..|:||
  Rat   319 LTPGMDHPLSLQPASMMGPLTQQLGHLSLN-SLGTFMPAAAAMQGTYISQYPAVPSSS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	25/79 (32%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	22/77 (29%)
Rbms2	XP_006240804.1	RRM_SF	47..132	CDD:302621	28/90 (31%)
Rbms2	XP_006240804.1	RRM2_MSSP2	133..218	CDD:240918	31/150 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910