Protein Alignment Sxl and bru2

DIOPT Version :10

• Sequence 1: NP_001259303.1
• Gene: Sxl / 3772180
• FlyBaseID: FBgn0264270
• Length: 722
• Species: Drosophila melanogaster
• Sequence 2: NP_001036356.1
• Gene: bru2 / 250811
• FlyBaseID: FBgn0262475
• Length: 893
• Species: Drosophila melanogaster
• Alignment Length: 769
• Identity: 160/769 - (20%)
• Similarity: 246/769 - (31%)
• Gaps: 248/769 - (32%)

  Fly    48 PSSSSRRGYNDFPGCGGSGG--------NGGSANNLGGGNMCHLPPMASNNSLNNLCGLS---LG 101
            ||:......|.....|..||        ...:|...||.|        .|.|....|.:.   :.
  Fly   223 PSTQLNSSINSRTSLGDQGGAIVVVTPAPPVAAPPTGGPN--------RNQSPTRDCSVKMELME 279

  Fly   102 SGGSDDLMNDPRASNTNLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFT 166
            |...|.:.:.|.|.|..:.|..:|:...:..|..:|...||::|..::||..|..|.|..||.:.
  Fly   280 STSPDSIKDQPDADNIKMFVGQIPKTWDETRLRQMFEQFGPVHTLNVLRDKVTSISRGCCFVTYY 344

  Fly   167 SEMDSQRAIKVLNGI-TVRNKRLKVSYARPGGESIKDTNLYVTNLPRTITDDQLDTIFGKYGSIV 230
            :...:.||...|:.| |:......:.......|:..:..|:|..|.:..|:..:..:|..:|:|.
  Fly   345 TRKAALRAQDALHNIKTLDGMHHPIQMKPADSENRNERKLFVGMLNKKYTEADVRQLFTGHGTIE 409

  Fly   231 QKNILRDKLTGRPRGVAFVRYNKREEAQEAISALN-NVIPEGGSQPLSVRLAEEHGKAKAAHFMS 294
            :..:|||: .|:.:|.|||.:..::.|..||.||: :...||.|.||.|:.|:.. |.|....|.
  Fly   410 ECTVLRDQ-AGQSKGCAFVTFATKQNAIGAIKALHQSQTMEGCSAPLVVKFADTQ-KEKDQKKMQ 472

  Fly   295 Q---------------------MGVVPANVPPPP------PQPPAHMAA---------------- 316
            |                     :....|.:..||      |...|.:||
  Fly   473 QIHAFCGINTPSGATAGAATPTINAATALIAAPPSAGRTNPSMAAALAAVPQVQQAGSAATAPTT 537

  Fly   317 -------------------AFNMMHRDGAMEKLRSLFDAICDAIFGLDSENFADL---------- 352
                               |.|..|: ||         |...|..|.|....|.|
  Fly   538 LVPLNSTTALSASLTPNLLATNAAHQ-GA---------AAAAAYLGADPAAAAHLQLYQQLHGYG 592

  Fly   353 ------LDGLYRRKYHYPYLXLTPQQQQQLLQHQQ----------QALGFTSSSN---------- 391
                  |.||   .:|:|     |:......||..          .|...|::||
  Fly   593 LSPAHYLPGL---NFHHP-----PENSAHHSQHSPGIGGASAASLSAAAATAASNPLGGAPPPTP 649

  Fly   392 ---NSIGNGNG------------NDNNMLLYHQQYHQQQTQQQRLGNVAAHNISPNGSNNNINTS 441
               :|.|:..|            |...:|.....:||          ::.|:.|.:..:||.|:|
  Fly   650 TPTSSAGHAAGAGLLAAPSMSMQNLVALLATPTAHHQ----------LSLHHSSSSSGHNNGNSS 704

  Fly   442 NTNNINFNTIRQNGVAALHYLQEQLQLQQPQDQQSQQQQPLTMPSSPPFQQQSRQSHHNGSSSTL 506
            .|:.::                               .|.||..::||          ....||.
  Fly   705 ATSGLH-------------------------------NQRLTYAAAPP----------PPPISTT 728

  Fly   507 GNQLLAISNNNSFNNNSNQSNSFTGN----------YSNGSAFTSNGAISGSNFPNNPTSSGNFT 561
            .|....|.:..:.......|.|.|.|          ||:..:..:|||..|:       :|...|
  Fly   729 YNMPQLIGHTATPTQPGGSSQSLTFNALWPPNAADPYSSSLSGLTNGAAYGA-------ASQPVT 786

  Fly   562 NNSTNSNPTN-SGHFASNLAGSSNFTNHLSGSNNYTNSNGNFT--SNAASSSNFSNNAASSTNYS 623
            .::..:.... :|.......||:.|..||......|:....|.  .|..|:..|.:   ..||.|
  Fly   787 TSALQAAAAGVTGKQIEGPDGSNLFIYHLPQEFIDTDLASTFLPFGNVLSAKVFID---KQTNLS 848

  Fly   624 KNCSSGVVGNSDPDSCSRKHTTNTNNHHTSPQHDFSFNMSTTEQELHQQTLKLQ 677
            | | .|.|...:|.|.         |......|.|         ::..:.||:|
  Fly   849 K-C-FGFVSYDNPHSA---------NAAIQAMHGF---------QIGSKRLKVQ 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	sex-lethal	16..297	CDD:273740	69/282 (24%)
bru2	NP_001036356.1	RRM_SF	294..375	CDD:473069	20/80 (25%)
		RRM_SF	381..461	CDD:473069	26/80 (33%)
		RRM_SF	801..892	CDD:473069	25/105 (24%)