DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sxl and HNRNPA3

DIOPT Version :9

Sequence 1:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster
Sequence 2:	NP_001317178.1	Gene:	HNRNPA3 / 220988	HGNCID:	24941	Length:	378	Species:	Homo sapiens

Alignment Length:	497	Identity:	96/497 - (19%)
Similarity:	149/497 - (29%)	Gaps:	160/497 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 NDPRASN--TNLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFT--SEMD 170
            :||:...  ..|.:..|..:.||..|...|...|.:..|.:|||.:|..|.|:.||.::  .|:|
Human    26 HDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVD 90

  Fly   171 S---QRAIKVLNGITVRNKRL--KVSYARPGGE-SIKDTNLYVTNLPRTITDDQLDTIFGKYGSI 229
            :   .|..|| :|..|..||.  :....:||.. ::|  .::|..:.....:..|...|.|||.|
Human    91 AAMCARPHKV-DGRVVEPKRAVSREDSVKPGAHLTVK--KIFVGGIKEDTEEYNLRDYFEKYGKI 152

  Fly   230 VQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVRLAEEHGKAKAAHFMS 294
            ....::.|:.:|:.||.|||.::..:...:.:....:.| .|.:..:...|:::..::..    |
Human   153 ETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTI-NGHNCEVKKALSKQEMQSAG----S 212

  Fly   295 QMGVVPANVPPPPPQPPAHMAAAFNMMHRDGAMEKLRSLFDAICDAIFGLDSENFADLLDGLYRR 359
            |.|               ....:.|.|.|.|.               ||....||.  ..|.:..
Human   213 QRG---------------RGGGSGNFMGRGGN---------------FGGGGGNFG--RGGNFGG 245

  Fly   360 KYHYPYLXLTPQQQQQLLQHQQQALGFTSSSNNSIGNGNGNDNNMLLYHQQYHQQQTQQQRLGNV 424
            :..|.                    |....|..|.|.|:|..|..
Human   246 RGGYG--------------------GGGGGSRGSYGGGDGGYNGF-------------------- 270

  Fly   425 AAHNISPNGSNNNINTSNTNNINFNTIRQNGVAALHYLQEQLQLQQPQDQQSQQQQPLTMPSSPP 489
                   .|...|..                                              ..|.
Human   271 -------GGDGGNYG----------------------------------------------GGPG 282

  Fly   490 FQQQSRQSHHNGSSSTLGNQLLAISNNNSFNNNSNQSNSFTGNYSNGSAFTSNGAISGSNFPN-N 553
            :   |.:..:.|.....|||.........::..:...|...|||..|..:...|..||....| .
Human   283 Y---SSRGGYGGGGPGYGNQGGGYGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYG 344

  Fly   554 PTSSGNFTNNSTNSNPTNSGHFASNLAGSSNFTNHLSGSNNY 595
            |...|:|...|:.| |...|:      ||.      .||..|
Human   345 PMKGGSFGGRSSGS-PYGGGY------GSG------GGSGGY 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	26/86 (30%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	16/77 (21%)
HNRNPA3	NP_001317178.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		2/8 (25%)
		RRM1_hnRNPA_like	36..113	CDD:409992	25/77 (32%)
		RRM2_hnRNPA3	126..205	CDD:409996	18/81 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..225		4/39 (10%)
		HnRNPA1	331..>347	CDD:402981	5/15 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..378		15/51 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920