Protein Alignment Sxl and HNRNPA1L2

DIOPT Version :9

• Sequence 1: NP_001259303.1
• Gene: Sxl / 3772180
• FlyBaseID: FBgn0264270
• Length: 722
• Species: Drosophila melanogaster
• Sequence 2: NP_001011724.1
• Gene: HNRNPA1L2 / 144983
• HGNCID: 27067
• Length: 320
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 85/511 - (16%)
• Similarity: 131/511 - (25%)
• Gaps: 233/511 - (45%)

  Fly   119 LIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKV----LN 179
            |.:..|..:.||..|.:.|...|.:..|.:|||..|..|.|:.||.:.:..:...|:..    ::
Human    16 LFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNTTPHKVD 80

  Fly   180 GITVRNKRL--KVSYARPGGE-SIKDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTG 241
            |..|..||.  :....|||.. ::|  .::|..:.....:..|...|.:||.|....|:.|:.:|
Human    81 GRVVEPKRAVSREDSQRPGAHLTVK--KIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSG 143

  Fly   242 RPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVRLAEEHGKAKAAHFMSQMGVVPANVPPP 306
            :.||.|||.:                              ::|
Human   144 KKRGFAFVTF------------------------------DDH---------------------- 156

  Fly   307 PPQPPAHMAAAFNMMHRDGAMEKLRSLFDAICDAIFGLDSENFADLLDGLYRRKYHYPYLXLTPQ 371
                                                        |.:|.:..:|||
Human   157 --------------------------------------------DSVDKIVIQKYH--------- 168

  Fly   372 QQQQLLQHQQQALGFTSSSNNSIGNGNGNDNNMLLYHQQYHQQQTQQQRLGNVAAHNISPNGSNN 436
                                                               .|..||..
Human   169 ---------------------------------------------------TVKGHNCE------ 176

  Fly   437 NINTSNTNNINFNTIRQNGVAALHYLQEQLQLQQPQDQQSQQQQPLTMPSSPPFQQQSRQSHHNG 501
                          :|:                             .:|........|.|....|
Human   177 --------------VRK-----------------------------ALPKQEMASASSSQRGRRG 198

  Fly   502 SSSTLGNQLLAISNNNSFNNNSNQS------NSFTGNYSNGSAFTSNG-AISGSNFPNNPTSS-- 557
            |.:..|.:......|::|....|.|      .|..|....||....|| ...||||....:.:
Human   199 SGNFGGGRGDGFGGNDNFGRGGNFSGRGGFGGSCGGGGYGGSGDGYNGFGNDGSNFGGGGSYNDF 263

  Fly   558 GNFTNNSTNSNPTNSGHFASNLAGSSNFTNHLSGSNNY----TNSNGNFTSNAASS 609
            ||:.|.|:|..|...|:|....:|.      ..|...|    .|..|...|:::||
Human   264 GNYNNQSSNFGPMKGGNFGGRSSGP------YGGGGQYFAKPQNQGGYGVSSSSSS 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	23/83 (28%)
		RRM2_Hu_like	203..281	CDD:240822	14/77 (18%)
HNRNPA1L2	NP_001011724.1	Globular A domain	4..94		21/77 (27%)
		RRM1_hnRNPA1	12..92	CDD:410154	21/75 (28%)
		Globular B domain	95..185		29/296 (10%)
		RRM_SF	105..184	CDD:418427	26/285 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..216		7/34 (21%)
		RNA-binding RGG-box	218..240		4/21 (19%)
		HnRNPA1	255..292	CDD:402981	9/42 (21%)
		Nuclear targeting sequence. /evidence=ECO:0000250	268..305		10/42 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..320		12/49 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920