Protein Alignment Sxl and Celf4

DIOPT Version :9

• Sequence 1: NP_001259303.1
• Gene: Sxl / 3772180
• FlyBaseID: FBgn0264270
• Length: 722
• Species: Drosophila melanogaster
• Sequence 2: NP_001349204.1
• Gene: Celf4 / 108013
• MGIID: 1932407
• Length: 554
• Species: Mus musculus
• Alignment Length: 525
• Identity: 120/525 - (22%)
• Similarity: 190/525 - (36%)
• Gaps: 132/525 - (25%)

  Fly    64 GSGGNGG-SANNLGGGNMCHLPPMASNNSLNNLCGLSLGSGGSDDL-MNDPRASNTNLIVNYLPQ 126
            |...|.. |.|.||          :|..|..::.|||...|....: |.|..|  ..|.:..:|:
Mouse    11 GQADNASLSTNGLG----------SSPGSAGHMNGLSHSPGNPSTIPMKDHDA--IKLFIGQIPR 63

  Fly   127 DMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDF---TSEMDSQRAI---KVLNGITVRN 185
            ::.:::|..||...|.|....:::|..||...|.||:.:   .|.:.:|.|:   |.|.|:   |
Mouse    64 NLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKTLPGM---N 125

  Fly   186 KRLKV----SYARPGGESIKD----TNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGR 242
            :.::|    |.:|.|...::.    ..|:|..|.:..::|.:..:|..:|:|.:..|||.. .|.
Mouse   126 RPIQVKPADSESRGGSSCLRQPPSHRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGP-DGN 189

  Fly   243 PRGVAFVRYNKREEAQEAISAL--NNVIPEGGSQPLSVRLAE---EHGKAKAAHFMSQMGVV-PA 301
            .:|.|||:|:...|||.||:||  :..:| |.|..|.|:.|:   |....:......|||:. |.
Mouse   190 SKGCAFVKYSSHAEAQAAINALHGSQTMP-GASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPM 253

  Fly   302 NVPPPPPQPPAHMAAAFNMMHRDGAMEKLRSLFDAICDAIFGLDSENFADLLDGLYRRKYHYPYL 366
            .:|     ..|:.|.|..:|.:..|:                     .|.:..|.|..    |..
Mouse   254 AIP-----FGAYGAYAQALMQQQAAL---------------------MASVAQGGYLN----PMA 288

  Fly   367 XLTPQQQQQLLQHQQQAL---------------GFTSSSNNSIGNGNGNDNNMLLYHQQYHQQQT 416
            .....|.||:.......|               |.|:.:..||.:..|.:....|..|...|...
Mouse   289 AFAAAQMQQMAALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAA 353

  Fly   417 QQQRLGNVAAHNISPNGSNNNINTSNTNNINFNTIRQNGVAALHYLQEQLQLQQ---PQDQQSQQ 478
            :.     |.|:.|.|..:                  |:..||....|....:||   |....:..
Mouse   354 EA-----VFANGIHPYPA------------------QSPTAADPLQQAYAGVQQYAGPAYPAAYG 395

  Fly   479 QQPLTMPSSPPFQQQSRQSHHNGSSSTL-------------------GNQLLAISNNNSFNNNSN 524
            |.....|..||...|.::....|.:..:                   ||   .||:....:..:|
Mouse   396 QISQAFPQPPPMIPQQQREGPEGCNLLIYHLPQEFGDAELMQMFLPFGN---VISSKVFVDRATN 457

  Fly   525 QSNSF 529
            ||..|
Mouse   458 QSKCF 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	23/89 (26%)
		RRM2_Hu_like	203..281	CDD:240822	28/79 (35%)
Celf4	NP_001349204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..39		9/30 (30%)
		RRM1_CELF3_4_5_6	49..135	CDD:241076	23/90 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..149		7/30 (23%)
		RRM2_CELF3_4_5_6	150..230	CDD:241079	28/81 (35%)
		Necessary for TNNT2 exon 5 inclusion. /evidence=ECO:0000250	238..257		5/23 (22%)
		RRM_SF	415..>463	CDD:388407	9/51 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910