DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex6 and PEX1

DIOPT Version :9

Sequence 1:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_012724.1	Gene:	PEX1 / 853636	SGDID:	S000001680	Length:	1043	Species:	Saccharomyces cerevisiae

Alignment Length:	865	Identity:	248/865 - (28%)
Similarity:	391/865 - (45%)	Gaps:	191/865 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 NLVIRGRRVRIGKPLASDEGNMTQTVIK----QMLQEAPHTIVAQILPAAQCQPNCLYVQEN-FY 184
            :||:...:|...:.:.::.|:..:|::|    |:|::.       ||.:..|:.:  :.::| |.
Yeast   177 SLVVVAPKVNKTRLVKAEYGHSNKTILKNGAIQLLKKV-------ILRSTVCKMD--FPKDNLFV 232

  Fly   185 GNILDRFQIRS--------NCWVQVEHFADEQT----IPGIATKAHVYLVADPHELPAE---LTE 234
            ..|.|..|:.|        .|.::....:|...    ||  :.|..|::..| .::|..   |:.
Yeast   233 VYISDGAQLPSQKGYASIVKCSLRQSKKSDSDNKSVGIP--SKKIGVFIKCD-SQIPENHIALSS 294

  Fly   235 VILSNYFNTPR-----------------LMHRGHTYRIEVNAELVGTATYAHY-YLIFAHLRHVH 281
            .:...:|..|.                 :..|..|..|:...:.|.|.:...| .|:...|...:
Yeast   295 HLWDAFFTHPMNGAKIKLEFLQMNQANIISGRNATVNIKYFGKDVPTKSGDQYSKLLGGSLLTNN 359

  Fly   282 L----KCIHLETKGSEFELQAIVAKNFSN-LVQVPASHSFLPRQVLDSMAIVENYPSGLRKPY-- 339
            |    :.|.:|.|..|.|.|.......|| .||...: .....:|.|   |:|.:   |.|.|
Yeast   360 LILPTEQIIIEIKKGESEQQLCNLNEISNESVQWKVT-QMGKEEVKD---IIERH---LPKHYHV 417

  Fly   340 ----KLLRSSVDA--FLPKKSA------CLSSKHI-FPVFLLQGERGSGKSKLVSAVAQEL--GM 389
                ::.|:|.|.  |:...|.      .|:|..| .|..:|.|::|.||::|:..:..|:  ..
Yeast   418 KETGEVSRTSKDEDDFITVNSIKKEMVNYLTSPIIATPAIILDGKQGIGKTRLLKELINEVEKDH 482

  Fly   390 HIY--GADCAEIVSQVPSHTEMKLKAVFAKSQVC---EPLMICFHNFE-IFG--------IDNEG 440
            ||:  .|||..:  ...|:.:...|.:......|   .|.:|...|.| :||        ..|.|
Yeast   483 HIFVKYADCETL--HETSNLDKTQKLIMEWCSFCYWYGPSLIVLDNVEALFGKPQANDGDPSNNG 545

  Fly   441 NED--LRLLSAFHVQVQELFNRDRKHPIVVVALTSDRHLKPMI--QGLFLEIINIDMPSKEERFE 501
            ..|  .:||:.|..||.::||:|.|...|:.:......:.|::  :....|..::..|.|..|.:
Yeast   546 QWDNASKLLNFFINQVTKIFNKDNKRIRVLFSGKQKTQINPLLFDKHFVSETWSLRAPDKHARAK 610

  Fly   502 ILRWMHVRETFNDIIYNQKAIEQLPLFSRENQSQFMPRISPSWRETLNVLQDVAAKSQGFLLGDL 566
            :|.:...:             .|:...:|:.|                 ..|::.:::||...||
Yeast   611 LLEYFFSK-------------NQIMKLNRDLQ-----------------FSDLSLETEGFSPLDL 645

  Fly   567 Q-----LLYDNAVRMKIRNRLGRTTLDMSHFAKNLTDMQSSFADSLGAPKVPKVYWSDIGGLAKL 626
            :     :.||..:.....|.:.|..     |:|:|:....|....:...|...:.|.|||.||..
Yeast   646 EIFTEKIFYDLQLERDCDNVVTREL-----FSKSLSAFTPSALRGVKLTKETNIKWGDIGALANA 705

  Fly   627 KDEIQSSIGLPLKHVHL-MGKNLR-RSGILLYGPPGTGKTLVAKAVATECNLSFLSVQGPELLNM 689
            ||.:..::..|.|:..: :...|| ||||||||.||.||||:|.|||.:|.|:|:||:|||:||.
Yeast   706 KDVLLETLEWPTKYEPIFVNCPLRLRSGILLYGYPGCGKTLLASAVAQQCGLNFISVKGPEILNK 770

  Fly   690 YVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNRGVAGDSGGVMDRVVSQLLAEMDGMS--DG 752
            ::|.||||:||:|.||:|..||:||.||.||:||.||  .||.||.||||:|||.:|||..  ||
Yeast   771 FIGASEQNIRELFERAQSVKPCILFFDEFDSIAPKRG--HDSTGVTDRVVNQLLTQMDGAEGLDG 833

  Fly   753 DTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGPCS--TAEDKAAVLRA---------QTQRF 806
                 ::|||||:||||||.|||||||.||...   |:  |..::..:|:|         ..::|
Yeast   834 -----VYILAATSRPDLIDSALLRPGRLDKSVI---CNIPTESERLDILQAIVNSKDKDTGQKKF 890

  Fly   807 ALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHLSGTISEKELVPENVIVQEEDF 871
            ||:...|::.|||: .:..|||||..:|.||:|.:|.|.:     ....:.|:||.|
Yeast   891 ALEKNADLKLIAEK-TAGFSGADLQGLCYNAYLKSVHRWL-----SAADQSEVVPGN-------- 941

  Fly   872 TKSFNKFVPSISAKDLEYFN 891
                         .::|||:
Yeast   942 -------------DNIEYFS 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	178/519 (34%)
		P-loop_NTPase	367..492	CDD:304359	36/144 (25%)
		AAA	653..787	CDD:278434	84/135 (62%)
PEX1	NP_012724.1	PEX-1N	108..183	CDD:401267	2/5 (40%)
		SpoVK	457..929	CDD:223540	178/519 (34%)
		RecA-like_PEX1_r2	705..862	CDD:410934	93/166 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910