DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex6 and pex6

DIOPT Version :9

Sequence 1:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_001332652.5	Gene:	pex6 / 792998	ZFINID:	ZDB-GENE-081104-252	Length:	1071	Species:	Danio rerio

Alignment Length:	754	Identity:	259/754 - (34%)
Similarity:	390/754 - (51%)	Gaps:	115/754 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 IRSNCWVQVEHFADEQ--------TIPGIATKAHVYLVADPHELPAELTEVILSNYFNTPRLMHR 249
            |:...|.:.....|.|        :.|..|.:.|:..:..|......|...:|..:|:.|||:.:
Zfish   383 IKIKRWNKASSHTDPQISASACRCSSPPFAKELHIETIISPDYSALGLFSSVLHTHFSKPRLVQQ 447

  Fly   250 GHTYRI--EVNAELV--GTATYAHYYLIFAHLRHVHLKCIHLETKGSEFELQAIVA-KNFSNLVQ 309
            |:...:  :.:.||:  |:.....:.:::..::..   |   .....|.|..:.:| .:.::|..
Zfish   448 GNILAVPTQGHPELMENGSEGVLRWPVLYFRVKQA---C---GFSSEEEEASSYLADSSHTSLYM 506

  Fly   310 VPASHSFLPRQVLD--SMAIVENYPSGLRKPYKLLRSSVDAFLPK-----KSACLSSKHIFPVFL 367
            ..::||..|..||.  |.......|.||....:.|.:.:...|.:     |..|        ..|
Zfish   507 GGSAHSLCPYSVLPEASSFWTSLSPPGLSSTVEKLITIIQPHLNESTLILKRGC--------SIL 563

  Fly   368 LQGERGSGKSKLVSAVAQELGMHIYGADCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFHNFE 432
            |.|..||||...|.||::.|.:|:...||..:.:...:.:|.|:|:||.::::..|.::...|.:
Zfish   564 LMGPNGSGKFTAVRAVSRRLHLHLIKVDCVTLCADTAAASEAKIKSVFERAELHHPCLLLLRNLQ 628

  Fly   433 IFGIDNEGNE-DLR-------LLSAFHVQVQELFNRDRKHPIVVVALTSDRHLKPMIQGLFLEII 489
            :.|...:|.| |.|       |::|.|..|           :||.:::|...|...:...|:..:
Zfish   629 LLGQSRDGAETDCRVAATLCQLIAAVHTSV-----------VVVGSVSSQHELPSDVMAAFVHQV 682

  Fly   490 NIDMPSKEERFEILRWMHVRETFNDIIYNQKAIEQLPLFSRENQSQFMPRISPSWRETLNVLQDV 554
            .|:..|:::|..:|               ....|.|.|....|                  |..:
Zfish   683 AIESLSEDQRRMVL---------------SSLSEDLLLGKDVN------------------LGRI 714

  Fly   555 AAKSQGFLLGDLQLLYDNAVRMKIRNRLGRT-------------------TLDMSHFAKNLTDMQ 600
            |.::.||:||||..|..||.:...| ||..|                   ::....|:..|..:|
Zfish   715 AKQTAGFVLGDLCALLTNAGKAAHR-RLVETYFPEAVSEQEEEDLCVSGVSVTSEDFSAALDVLQ 778

  Fly   601 SSFADSLGAPKVPKVYWSDIGGLAKLKDEIQSSIGLPLKHVHLMGKNLRRSGILLYGPPGTGKTL 665
            .:.:.::||||:|.|.|.|:|||.::|.||..:|.|||:|..|:...|||||:||||||||||||
Zfish   779 EAHSQAIGAPKIPAVSWQDVGGLQQVKKEILDTIQLPLEHPELLSLGLRRSGLLLYGPPGTGKTL 843

  Fly   666 VAKAVATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNRGVAGD 730
            :||||||||.::||||:||||:||||||||:|:|:|.|:|||||||::|.|||||||||||.:||
Zfish   844 LAKAVATECTMTFLSVKGPELINMYVGQSEENIRQVSSKARSAAPCIIFFDELDSLAPNRGHSGD 908

  Fly   731 SGGVMDRVVSQLLAEMDGM-SDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGPCSTAED 794
            |||||||||||||||:||: |.||    :|::.|||||||:|.:||||||||||.|||.....|.
Zfish   909 SGGVMDRVVSQLLAELDGLHSSGD----VFVIGATNRPDLLDQSLLRPGRFDKLVYVGINEDRES 969

  Fly   795 KAAVLRAQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHLSGTISEKEL 859
            :..||:|..::|.:||.|.:..|.|.....::||||||:||:|.:.||:|.|.....|..||.
Zfish   970 QLQVLKAILRKFKVDASVCLSDIVESCPPRLTGADLYSLCSDAMMCAVKRKISRITEGVDSEL-- 1032

  Fly   860 VPENVIVQEEDFTKSFNKFVPSISAKDLEYFNNLKASYS 898
              .::.:..|||:::.:...||:|.:.:..:..|:...|
Zfish  1033 --SSLTLCSEDFSEALSGLQPSVSEQQISRYQLLQQKLS 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	211/507 (42%)
		P-loop_NTPase	367..492	CDD:304359	35/132 (27%)
		AAA	653..787	CDD:278434	101/134 (75%)
pex6	XP_001332652.5	SpoVK	561..1060	CDD:223540	221/551 (40%)
		P-loop_NTPase	562..>620	CDD:304359	19/57 (33%)
		AAA	834..962	CDD:278434	99/131 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592539
Domainoid	1	1.000	213	1.000	Domainoid score	I2699
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2046
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233419at2759
OrthoFinder	1	1.000	-	-		FOG0004626
OrthoInspector	1	1.000	-	-		oto40472
orthoMCL	1	0.900	-	-		OOG6_103617
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R903
SonicParanoid	1	1.000	-	-		X3235
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.930