DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex6 and PEX6

DIOPT Version :9

Sequence 1:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_000278.3	Gene:	PEX6 / 5190	HGNCID:	8859	Length:	980	Species:	Homo sapiens

Alignment Length:	821	Identity:	266/821 - (32%)
Similarity:	412/821 - (50%)	Gaps:	161/821 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 IGKPLASDEGNMTQTVIKQMLQEAPHTIVAQILPAAQCQP---NCLYVQENFYGNILDRFQIRSN 196
            :|:|||..            |...|.|:...:    .|.|   ..|.:|....|:|..  :.:.:
Human   262 LGEPLADG------------LALVPATLAFNL----GCDPLEMGELRIQRYLEGSIAP--EDKGS 308

  Fly   197 CWVQVEHFADEQTIPG--IATKAHVYLVADPHELPAELTEVILSNYFNTPRLMHRGHTYRIEVNA 259
            |          ..:||  .|.:.|:.:|:.||.......:.:|..:|..||::..|....:....
Human   309 C----------SLLPGPPFARELHIEIVSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVPTIG 363

  Fly   260 EL-----------------------VGTATYAHYYLIFAHLRHVHLKCIHLETKGSEFELQAIVA 301
            ::                       ||.|.........|...|..|               .:|.
Human   364 QVEILEGSPEKLPRWREMFFKVKKTVGEAPDGPASAYLADTTHTSL---------------YMVG 413

  Fly   302 KNFSNLVQVPASHSFLPRQVLDSMAIVENYPSGLRKPYKLLRSSVDAFLPKKSACLSSKHIFPVF 366
            ...|.:..:|:..|.|    ..|::     |.||......|.:.:...|....|.|:..   ...
Human   414 STLSPVPWLPSEESTL----WSSLS-----PPGLEALVSELCAVLKPRLQPGGALLTGT---SSV 466

  Fly   367 LLQGERGSGKSKLVSAVAQELGMHIYGADCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFHNF 431
            ||:|..|.||:.:|:|....||:|:....|:.:.::.....|.||:|:|::::.|.|.::.....
Human   467 LLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAV 531

  Fly   432 EIFGIDNEG-NEDLRLLSAF-HVQVQELFNRDRKH---PIVVVALTS-DRHLKPMIQGLFLEIIN 490
            ::.|.|.:| .||.|:::.. |:    |.|.|..:   |::|||.|| .:.|...:|..|...:.
Human   532 DLLGRDRDGLGEDARVMAVLRHL----LLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELE 592

  Fly   491 IDMPSKEERFEILRWMHVRETFNDIIYNQKAIEQLPLFSRENQSQFMPRISPSWRETLNVLQDVA 555
            :...|:.:|..|||.:               ...|||....|.:|                  :|
Human   593 VPALSEGQRLSILRAL---------------TAHLPLGQEVNLAQ------------------LA 624

  Fly   556 AKSQGFLLGDLQLLYDNAVR---MKIRNR--LGRTT-------------LDMSHFAKNLTDMQSS 602
            .:..||::|||..|..::.|   .:|:|.  .|..|             |....|.:.|..:|::
Human   625 RRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTA 689

  Fly   603 FADSLGAPKVPKVYWSDIGGLAKLKDEIQSSIGLPLKHVHLMGKNLRRSGILLYGPPGTGKTLVA 667
            .:.::||||:|.|.|.|:|||.::|.||..:|.|||:|..|:...|||||:||:|||||||||:|
Human   690 HSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLA 754

  Fly   668 KAVATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNRGVAGDSG 732
            |||||||:|:||||:||||:||||||||:||||||:|||:||||::|.||||||||:||.:||||
Human   755 KAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSG 819

  Fly   733 GVMDRVVSQLLAEMDGMSDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGPCSTAEDKAA 797
            |||||||||||||:||:   .:::.:|::.|||||||:|||||||||||||.:||   ..||:|:
Human   820 GVMDRVVSQLLAELDGL---HSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVG---ANEDRAS 878

  Fly   798 ---VLRAQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHLSGTISEKEL 859
               ||.|.|::|.|:..|.:..:.:....:::||||||:||:|..:|::|.:..      .|:.|
Human   879 QLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHD------LEEGL 937

  Fly   860 VPEN--VIVQEEDFTKSFNKFVPSISAKDLEYFNNLKASYS 898
            .|.:  :::..||..::..:..||:|.::|..:..::..::
Human   938 EPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFA 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	212/506 (42%)
		P-loop_NTPase	367..492	CDD:304359	38/130 (29%)
		AAA	653..787	CDD:278434	100/133 (75%)
PEX6	NP_000278.3	SpoVK	463..967	CDD:223540	220/555 (40%)
		AAA	466..594	CDD:278434	38/131 (29%)
		AAA	743..871	CDD:278434	98/130 (75%)
		Vps4_C	918..977	CDD:286426	14/64 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156864
Domainoid	1	1.000	213	1.000	Domainoid score	I2759
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2184
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233419at2759
OrthoFinder	1	1.000	-	-		FOG0004626
OrthoInspector	1	1.000	-	-		oto89856
orthoMCL	1	0.900	-	-		OOG6_103617
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R903
SonicParanoid	1	1.000	-	-		X3235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.930