DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex6 and PEX1

DIOPT Version :9

Sequence 1:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_000457.1	Gene:	PEX1 / 5189	HGNCID:	8850	Length:	1283	Species:	Homo sapiens

Alignment Length:	909	Identity:	238/909 - (26%)
Similarity:	400/909 - (44%)	Gaps:	231/909 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QPRFSFSGRVQELVEGYNSAIQLLAPKWPWFLYPGYLTYAVYWRYAKYYKGK-FLLTPIPNRLYD 91
            :|.|:.:         |...::||:||                  .:..|.| .:|:|...:...
Human   325 EPSFTVT---------YGKLVKLLSPK------------------QQQSKTKQNVLSPEKEKQMS 362

  Fly    92 LLIKNEQIKSEH-----------LVFASQEVYEN---YAESPDVNFVNLVIRGRRVRIGKPLASD 142
            ..:..::|:|:|           :|:...|...|   |.::.:|           :.:||....|
Human   363 EPLDQKKIRSDHNEEDEKACVLQVVWNGLEELNNAIKYTKNVEV-----------LHLGKVWIPD 416

  Fly   143 EGNMTQTVIKQMLQEAPHTIV----AQILPAAQCQPNCLYVQ--ENFYGNILDRFQIRS--NCWV 199
            :       :::.|....|.:|    .::.|..   |..|.:|  ||...:|.:. .|::  ..|:
Human   417 D-------LRKRLNIEMHAVVRITPVEVTPKI---PRSLKLQPRENLPKDISEE-DIKTVFYSWL 470

  Fly   200 Q------------VEHFADEQTIPGIATKAHVYLVADPHELPAELTEVILSNYFNTPRLMHRGHT 252
            |            .|.|...:|..|:..    :.::..|....|..:.|   :..:|.|:.: .|
Human   471 QQSTTTMLPLVISEEEFIKLETKDGLKE----FSLSIVHSWEKEKDKNI---FLLSPNLLQK-TT 527

  Fly   253 YRI-------EVNAELVGTATYAHYYLIFAHLRHVHLKCIHLETKGSEFELQAIVAKNFSNLVQV 310
            .::       |.|:|.:      .:.|.|..|.                .|..:.:...|:|..:
Human   528 IQVLLDPMVKEENSEEI------DFILPFLKLS----------------SLGGVNSLGVSSLEHI 570

  Fly   311 PASHSFLPRQV-LDSMAIVENYPSGLRKPYKLLRSSVDAFLPKKSACLSSKHIFPVFLLQGERGS 374
              :||.|.|.: ...|::|    :|||.                          ...||.|.:||
Human   571 --THSLLGRPLSRQLMSLV----AGLRN--------------------------GALLLTGGKGS 603

  Fly   375 GKSKLVSAVAQE----LGMHIYGADCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFHNFE-IF 434
            |||.|..|:.:|    |..|:...||..:..:...:.:..|:..|:::...:|.::...:.: |.
Human   604 GKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIA 668

  Fly   435 GI----DNEGNEDL----RLLSAFHVQVQELFNRDRKHPIVVVALTSDRHLKPMI---QG--LFL 486
            |:    ::|.:.|.    ||..|.:..::|..:......::..: .|.:.|.|::   ||  :|.
Human   669 GLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATS-QSQQSLHPLLVSAQGVHIFQ 732

  Fly   487 EIINIDMPSKEERFEILRWMHVRETFNDIIYNQKAIEQLPLFSRENQSQFMPRISPSWRETLNVL 551
            .:.:|..|::|:|.|||         .::|.|:...: :..|:..:                  |
Human   733 CVQHIQPPNQEQRCEIL---------CNVIKNKLDCD-INKFTDLD------------------L 769

  Fly   552 QDVAAKSQGFLLGDLQLLYDNAVRMKI-------RNRLGRTTLDMSHFAKNLTDMQSSFADSLGA 609
            |.||.::.||:..|..:|.|.|:..::       |.:|..||||   |.|.|.....:...|:..
Human   770 QHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLD---FQKALRGFLPASLRSVNL 831

  Fly   610 PKVPKVYWSDIGGLAKLKDEIQSSIGLPLKHVHLMGKNL---RRSGILLYGPPGTGKTLVAKAVA 671
            .|...:.|..||||.:::..:..:|.||.|:..|.. ||   :|:||||||||||||||:|..:|
Human   832 HKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFA-NLPIRQRTGILLYGPPGTGKTLLAGVIA 895

  Fly   672 TECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNRGVAGDSGGVMD 736
            .|..::|:||:|||||:.|:|.|||.||::|.||::|.||:||.||.:|:||.||  .|:.||.|
Human   896 RESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRG--HDNTGVTD 958

  Fly   737 RVVSQLLAEMDGMSDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGPCSTAEDKAAVLRA 801
            |||:|||.::||:   :..:.:::||||:||||||||||||||.||..|..|.... .:..:|..
Human   959 RVVNQLLTQLDGV---EGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQV-SRLEILNV 1019

  Fly   802 QTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTI------DGHLSGTISEKEL 859
            .:....|...||::.:|. :....:||||.::..||.|.|:...:      ||..|   |:.:|
Human  1020 LSDSLPLADDVDLQHVAS-VTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSS---SDSDL 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	170/513 (33%)
		P-loop_NTPase	367..492	CDD:304359	32/142 (23%)
		AAA	653..787	CDD:278434	79/133 (59%)
PEX1	NP_000457.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..367		4/20 (20%)
		SpoVK	595..1063	CDD:223540	170/507 (34%)
		AAA	595..731	CDD:278434	31/136 (23%)
		AAA	877..1006	CDD:278434	79/133 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1283
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910