Protein Alignment Pex6 and Spast

DIOPT Version :10

• Sequence 1: NP_001027403.2
• Gene: Pex6 / 3772165
• FlyBaseID: FBgn0033564
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001156342.1
• Gene: Spast / 50850
• MGIID: 1858896
• Length: 614
• Species: Mus musculus
• Alignment Length: 316
• Identity: 100/316 - (31%)
• Similarity: 156/316 - (49%)
• Gaps: 45/316 - (14%)

  Fly   594 KNLTDMQSSFADSLGAPKVPK---VYWSDIGGLAKLKDEIQSSIGLP-LKHVHLMGKNLRRSGIL 654
            ||..::.|:.|:.:....|..   |.:.||.|....|..:|..:.|| |:.....|......|:|
Mouse   313 KNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAPARGLL 377

  Fly   655 LYGPPGTGKTLVAKAVATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELD 719
            |:||||.|||::|||||.|.|.:|.::....|.:.|||:.|:.||.:|:.||...|.::|:||:|
Mouse   378 LFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVD 442

  Fly   720 SLAPNRGVAGDSGGVMD---RVVSQLLAEMDGM-SDGDTSKPIFILAATNRPDLIDPALLRPGRF 780
            ||...|     ..|..|   |:.::.|.|.||: |.||..  :.::.|||||..:|.|:||  ||
Mouse   443 SLLCER-----REGEHDASRRLKTEFLIEFDGVQSAGDDR--VLVMGATNRPQELDEAVLR--RF 498

  Fly   781 DKLFYVGPCSTAEDKAAVLRAQTQRFALDAGVDMEQIAE--RLKSEMSGADLYSICSNAWLSAVR 843
            .|..||   |...::..:|..:.......:.:..:::|:  |:....||:||.::..:|.|..:|
Mouse   499 IKRVYV---SLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR 560

  Fly   844 RTIDGHLSGTISEKELVPENV---------IVQEEDFTKSFNKFVPSISAKDLEYF 890
                          ||.||.|         .::..|||:|..|...|:|.:.||.:
Mouse   561 --------------ELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAY 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_001027403.2	SpoVK	<367..600	CDD:440232	2/5 (40%)
		RPT1	<609..883	CDD:440835	93/292 (32%)
Spast	NP_001156342.1	Required for interaction with RTN1. /evidence=ECO:0000250|UniProtKB:Q9UBP0	1..298
		Required for midbody localization. /evidence=ECO:0000250|UniProtKB:Q9UBP0	1..192
		Required for interaction with ATL1. /evidence=ECO:0000250|UniProtKB:Q9UBP0	1..78
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48
		Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q9UBP0	1..48
		Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021	4..11
		Required for interaction with SSNA1 and microtubules. /evidence=ECO:0000250|UniProtKB:Q9UBP0	48..85
		Nuclear export signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021	57..65
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..112
		Sufficient for interaction with CHMP1B. /evidence=ECO:0000250|UniProtKB:Q9UBP0	110..194
		Required for interaction with microtubules. /evidence=ECO:0000250|UniProtKB:Q9UBP0	112..198
		MIT_spastin	114..193	CDD:239142
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..306
		Sufficient for microtubule severing. /evidence=ECO:0000250|UniProtKB:Q9UBP0	226..614		100/316 (32%)
		Required for interaction with microtubules and microtubule severing. /evidence=ECO:0000250|UniProtKB:Q9UBP0	268..326		4/12 (33%)
		Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021	307..310
		Required for interaction with microtubules. /evidence=ECO:0000250|UniProtKB:Q9UBP0	308..310
		RecA-like_spastin	341..504	CDD:410932	67/171 (39%)
		AAA_lid_3	531..585	CDD:465537	16/67 (24%)
		Vps4_C	<578..610	CDD:462762	9/25 (36%)