Protein Alignment Pex6 and spas

DIOPT Version :10

• Sequence 1: NP_001027403.2
• Gene: Pex6 / 3772165
• FlyBaseID: FBgn0033564
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Alignment Length: 767
• Identity: 184/767 - (23%)
• Similarity: 287/767 - (37%)
• Gaps: 210/767 - (27%)

  Fly   216 KAHVYLVADP--------HELPAELTEVILSNYFNTPRLMHRGHTYRIEVNAELVGTATYAHYYL 272
            |.::|:|:.|        ..|..:|..:....|..:.::::|.|  |.:.|.|:|...:......
  Fly   112 KQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPH--RRDCNIEIVVQNSSKEQQQ 174

  Fly   273 IFAHLRHVHLKCIHLETKGSEFELQAIVAKNFSNLVQVPASHSFLPRQVLDSMAIVENYPSGLRK 337
            ...|...     ::.|..|.|.:|        ||..|     .|.|.|.|:..|   |.|.|...
  Fly   175 SLNHPSE-----LNREGDGQEQQL--------SNQPQ-----RFRPIQPLEMAA---NRPGGGYS 218

  Fly   338 PYKLLRSSVDAFLPKKSACLSSKH--------IFPVFLLQGERGSGKSKLVSAVAQELGMHIYGA 394
            |     ...|..|.|:      ||        |.....:..|....|         ||.:.:|..
  Fly   219 P-----GPGDPLLAKQ------KHHHRRAFEYISKALKIDEENEGHK---------ELAIELYRK 263

  Fly   395 DCAEIVSQVP----------------SHTEMKLKAVFAKSQVCEPLMICFHNFEIFGIDNEGNED 443
            ...|:...:.                .|.:|:.....|:.::        |...:    .|.:..
  Fly   264 GIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRL--------HFLAL----REQDLQ 316

  Fly   444 LRLLSAFHVQVQELFNRDRKHPIVVVALTSDRHLKPMIQGLFLEIINIDMPSKEERFEILRWMHV 508
            ::.||....|.:|..::.:|            ..:||:.|:..|      |.|         :.|
  Fly   317 MQRLSLKEKQKEEAQSKPQK------------TREPMLAGMTNE------PMK---------LRV 354

  Fly   509 RETFNDIIYNQKAI---------EQLPLFSRE-------NQSQFMPRISPSWRETLNVLQDVAAK 557
            |.:.    |..||.         .:|.:.|:.       |:||.:||...| :.::..:|...||
  Fly   355 RSSG----YGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGS-KTSVGAVQRQPAK 414

  Fly   558 SQGFLLGDLQLLYDNAVRMKIRNRLGRTTLDMSHFAKNLTDMQSSFADSLGA--PKV-------- 612
            :..         ...|||.:..:  ||.|...    ::.|.:.::.....||  |.|
  Fly   415 TAA---------TPPAVRRQFSS--GRNTPPQ----RSRTPINNNGPSGSGASTPVVSVKGVEQK 464

  Fly   613 -------------PKVYWSDIGGLAKLKDEIQSSIGLPLKHVHLM-GKNLRRSGILLYGPPGTGK 663
                         .||.|:||.|....|..:|..:.||.....|. |......|:||:||||.||
  Fly   465 LVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGK 529

  Fly   664 TLVAKAVATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNRGVA 728
            ||:|:||||||:.:||::....|.:.|||..|:.||.:|:.||...|.::|:||:|||...|  :
  Fly   530 TLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSER--S 592

  Fly   729 GDSGGVMDRVVSQLLAEMDGM---SDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVG-PC 789
            ........|:.::.|.|.||:   .|||.   |.:|||||||..:|.|.||  ||.|..||. |.
  Fly   593 SSEHEASRRLKTEFLVEFDGLPGNPDGDR---IVVLAATNRPQELDEAALR--RFTKRVYVSLPD 652

  Fly   790 STAEDKAAVLRAQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHLSGTI 854
            ....:.......|.|...||... :.::| ::....||:||.::..:|.|..:|
  Fly   653 EQTRELLLNRLLQKQGSPLDTEA-LRRLA-KITDGYSGSDLTALAKDAALEPIR----------- 704

  Fly   855 SEKELVPENV---------IVQEEDFTKSFNKFVPSISAKDLEYFNNLKASY 897
               ||..|.|         .:.|:||..|..:...|::.:.|..:......|
  Fly   705 ---ELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDY 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_001027403.2	SpoVK	<367..600	CDD:440232	45/264 (17%)
		RPT1	<609..883	CDD:440835	100/310 (32%)
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	13/94 (14%)
		RecA-like_spastin	484..648	CDD:410932	70/170 (41%)
		AAA_lid_3	676..727	CDD:465537	13/65 (20%)
		Vps4_C	<722..754	CDD:462762	7/32 (22%)