DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex6 and TER94

DIOPT Version :9

Sequence 1:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	918	Identity:	246/918 - (26%)
Similarity:	400/918 - (43%)	Gaps:	206/918 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GRVQELVEGYNS-AIQLLAPKWPWFLYPGYLTYAVYWRYAKYYKGKFLLTPI------PNRLYDL 92
            |..::.:.||:| ..:.:.||                  ..:.|.:.|.|.|      |||   |
  Fly     5 GDTRDFMRGYHSEQDEKMKPK------------------DSFDKREDLATAILKRKDRPNR---L 48

  Fly    93 LIKNEQIKSEHLVFASQEVYENYAESPDVNFV---NLVIRGRRVRIGKPLASDEGNMTQTVIKQM 154
            :::..|.....:|..||      |:..::...   .::::|:|.:             :||
  Fly    49 IVEEAQNDDNSVVSLSQ------AKMDELQLFRGDTVILKGKRRK-------------ETV---- 90

  Fly   155 LQEAPHTIVAQILPAAQCQPNCLYVQENFYGNILDRFQ--IRSNCWVQVEHFADEQTIPGI--AT 215
                                 |:.:.::...:...|..  :|:|..|.:......|:.|.:  ..
  Fly    91 ---------------------CIVLSDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGK 134

  Fly   216 KAHVYLVADPHE-LPAELTEVILSNYF-NTPRLMHRGHTYRIEVNAELVGTATYAHYYLIFAHLR 278
            :..:..:.:..| :...|.|:.|..|| ...|.:|.|..                  :::.|.:|
  Fly   135 RVRILPIDESTEGVTGNLFEIYLKPYFLEAYRPIHMGDN------------------FIVRAAMR 181

  Fly   279 HVHLKCIHLETKGSEFELQAIVAKNFSNLVQVPASHSF-----LPRQVLDSMAIVENYP--SGLR 336
            .:..|.:..:.     |...|||         |.:..|     :.|:..:.......|.  .|.|
  Fly   182 PIEFKVVLTDP-----EPYCIVA---------PETVIFCDGDPIKREEEEESLNAVGYDDIGGCR 232

  Fly   337 KPYKLLRSSVDAFLPKKSACL-SSKHIFPV--FLLQGERGSGKSKLVSAVAQELGMHIYGADCAE 398
            |....::..|:  ||.:...| .:..:.|.  .|:.|..|:||:.:..|||.|.|...:..:..|
  Fly   233 KQLAQIKEMVE--LPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFFLINGPE 295

  Fly   399 IVSQVPSHTEMKLKAVFAKSQVCEPLMICFHNFEIFGIDNE---GNEDLRLLSAFHVQVQELFNR 460
            |:|::...:|..|:..|.:::...|.:|.....:......:   |..:.|::|    |:..|.:.
  Fly   296 IMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVS----QLLTLMDG 356

  Fly   461 DRK--HPIVVVALTSDRHLKPMIQ--GLFLEIINIDMPSKEERFEILRWMHVRETFNDIIYNQKA 521
            .:|  |.||:.|......:.|.::  |.|...|:|.:|....|.|:|| :|.:        |.|.
  Fly   357 MKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLR-IHTK--------NMKL 412

  Fly   522 IEQLPLFSRENQSQFMPRISPSWRETLNVLQDVAAKSQGFLLGDLQLLYDNAVRMKIRNRLGRTT 586
            .:.:.                        |:.:||:|.|.:..||..|...|...:||.::....
  Fly   413 HDDVD------------------------LEQIAAESHGHVGADLASLCSEAALQQIREKMDLID 453

  Fly   587 L-----DMSHFAKNLTDMQS-SFADSLGAP--------KVPKVYWSDIGGLAKLKDEIQSSIGLP 637
            |     |....|.....|:: .:|.:..:|        :||...|:|||||..:|.|:|..:..|
  Fly   454 LEDDKIDAEVLASLAVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYP 518

  Fly   638 LKHVHLMGK-NLRRS-GILLYGPPGTGKTLVAKAVATECNLSFLSVQGPELLNMYVGQSEQNVRE 700
            ::|.....| .::.| |:|.|||||.||||:|||:|.||..:|:||:|||||.|:.|:||.|||:
  Fly   519 VEHPDKFLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRD 583

  Fly   701 VFSRARSAAPCVLFLDELDSLAPNR-GVAGDSGGVMDRVVSQLLAEMDGMSDGDTSKPIFILAAT 764
            :|.:||||||||||.|||||:|..| |..||:||..|||::|:|.|||||.   ..|.:||:.||
  Fly   584 IFDKARSAAPCVLFFDELDSIAKARGGNVGDAGGAADRVINQILTEMDGMG---AKKNVFIIGAT 645

  Fly   765 NRPDLIDPALLRPGRFDKLFYVGPCSTAEDKAAVLRAQTQRFALDAGVDMEQIAERLKSEMSGAD 829
            ||||:||||:|||||.|:|.|: |....:.:.|:|:|..::..|...||:..|| ::....||||
  Fly   646 NRPDIIDPAILRPGRLDQLIYI-PLPDDKSREAILKANLRKSPLAKEVDLTYIA-KVTQGFSGAD 708

  Fly   830 LYSICSNAWLSAVRRTIDGHL------------SGTISEKELVPENVIVQEEDFTKSFNKFVPSI 882
            |..||..|...|:|:.|:..:            :..:.|.:.|||......|:..|...:   |:
  Fly   709 LTEICQRACKLAIRQAIEAEIRREKERAENQNSAMDMDEDDPVPEITSAHFEEAMKFARR---SV 770

  Fly   883 SAKDLEYF 890
            |..|:..:
  Fly   771 SDNDIRKY 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	178/503 (35%)
		P-loop_NTPase	367..492	CDD:304359	32/131 (24%)
		AAA	653..787	CDD:278434	85/134 (63%)
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	234/858 (27%)
		CDC48_N	47..129	CDD:280513	17/128 (13%)
		CDC48_2	153..213	CDD:215011	16/91 (18%)
		AAA	263..392	CDD:278434	32/132 (24%)
		AAA	536..669	CDD:278434	85/136 (63%)
		Vps4_C	<741..783	CDD:286426	9/41 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445206
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23077
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940