DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex6 and vcp

DIOPT Version :9

Sequence 1:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_958889.1	Gene:	vcp / 327197	ZFINID:	ZDB-GENE-030131-5408	Length:	806	Species:	Danio rerio

Alignment Length:	753	Identity:	217/753 - (28%)
Similarity:	350/753 - (46%)	Gaps:	140/753 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 IRSNCWVQVEHFADEQTIPGI--ATKAHVYLVADPHE-LPAELTEVILSNYF-NTPRLMHRGHTY 253
            :|:|..|::......|..|.:  ..:.||..:.|..| :...|.||.|..|| ...|.:.:|..:
Zfish    88 VRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIF 152

  Fly   254 RIE-----VNAELVGTATYAHYYLIFAHLRHVHLKCIHLETKGSEFELQAI-------VAKNFS- 305
            .:.     |..::|.|....  |.|.|....:|.:...::.:..|..|..:       |.|..:
Zfish   153 LVRGGMRAVEFKVVETDPSP--YCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGVRKQLAQ 215

  Fly   306 --NLVQVPASHSFLPRQVLDSMAIVENYPSGLRKPYKLLRSSVDAFLPKKSACLSSKHIFPVFLL 368
              .:|::|..|..|.:.:            |::.|..:                         ||
Zfish   216 IKEMVELPLRHPALFKAI------------GVKPPRGI-------------------------LL 243

  Fly   369 QGERGSGKSKLVSAVAQELGMHIYGADCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFHNFEI 433
            .|..|:||:.:..|||.|.|...:..:..||:|::...:|..|:..|.:::...|.:|.....:.
Zfish   244 YGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDA 308

  Fly   434 FGIDNE---GNEDLRLLSAFHVQVQELFNRDRKHPIVVVALTSDRHLKPMIQ--GLFLEIINIDM 493
            .....|   |..:.|::|.....:..|  :.|.|.||:.|......:.|.::  |.|...::|.:
Zfish   309 IAPKREKTHGEVERRIVSQLLTLMDGL--KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGI 371

  Fly   494 PSKEERFEILRWMHVRETFNDIIYNQKAIEQLPLFSRENQSQFMPRISPSWRETLNVLQDVAAKS 558
            |....|.|||: :|.:        |.|..:.:.                        |:.||.::
Zfish   372 PDATGRLEILQ-IHTK--------NMKLADDVD------------------------LEQVANET 403

  Fly   559 QGFLLGDLQLLYDNAVRMKIRNRLGRTTLD--------MSHFAKNLTDMQSSFADSLGAP----- 610
            .|.:..||..|...|....||.::....|:        |:..|..:.|.:.:.:.|..:.
Zfish   404 HGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETV 468

  Fly   611 -KVPKVYWSDIGGLAKLKDEIQSSIGLPLKHVHLMGKNLR-----RSGILLYGPPGTGKTLVAKA 669
             :||.:.|.|||||..:|.|:|..:..|::|   ..|.|:     ..|:|.|||||.||||:|||
Zfish   469 VEVPNITWEDIGGLDDVKRELQELVQYPVEH---PDKFLKFGMTPSKGVLFYGPPGCGKTLLAKA 530

  Fly   670 VATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNR-GVAGDSGG 733
            :|.||..:|:|::|||||.|:.|:||.||||:|.:||.|||||||.|||||:|..| |..||.||
Zfish   531 IANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNVGDGGG 595

  Fly   734 VMDRVVSQLLAEMDGMSDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGPCSTAEDKAAV 798
            ..|||::|:|.||||||   :.|.:||:.||||||:||||:|||||.|:|.|: |....:.:.|:
Zfish   596 AADRVINQILTEMDGMS---SKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI-PLPDEKSRIAI 656

  Fly   799 LRAQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHL-----------SG 852
            |:|..::..:...||::.:| ::.:..|||||..||..|...|:|.:|:..:           :.
Zfish   657 LKANLRKSPISKDVDLDFLA-KMTNGFSGADLTEICQRACKLAIRESIENEIRRERERQTNPSAM 720

  Fly   853 TISEKELVPENVIVQEEDFTKSFNKFVPSISAKDLEYF 890
            .:.|.:.|||   ::::.|.::......|:|..|:..:
Zfish   721 EVEEDDPVPE---IRKDHFEEAMRFARRSVSDNDIRKY 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	174/504 (35%)
		P-loop_NTPase	367..492	CDD:304359	32/129 (25%)
		AAA	653..787	CDD:278434	85/134 (63%)
vcp	NP_958889.1	CDC48	25..764	CDD:273521	217/753 (29%)
		CDC48_N	25..107	CDD:280513	4/18 (22%)
		CDC48_2	131..191	CDD:215011	14/61 (23%)
		AAA	241..370	CDD:278434	32/155 (21%)
		P-loop_NTPase	452..>534	CDD:304359	31/84 (37%)
		AAA	514..647	CDD:278434	85/136 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727		1/18 (6%)
		Vps4_C	<718..760	CDD:286426	8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910