DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex6 and prx-6

DIOPT Version :9

Sequence 1:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_504268.1	Gene:	prx-6 / 266912	WormBaseID:	WBGene00004195	Length:	720	Species:	Caenorhabditis elegans

Alignment Length:	814	Identity:	231/814 - (28%)
Similarity:	379/814 - (46%)	Gaps:	153/814 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 LIKNEQIKSEHLVFASQEVYENYAESPDVNFVNLVIRGRRVRIGKPLASDEGNMTQTVIKQMLQE 157
            |:.||:::.:.:|..|.......:..|...:...::..:.|:....:.:|.|. :..:.:.|..:
Worm    27 LLWNEEVELKIVVDQSGASINTLSIHPVTCWSLGILDSQLVKTSFTITTDHGK-SSNIERVMKVQ 90

  Fly   158 APHTIVAQILPAAQCQPNCLY----VQENFYGNILDRFQIRSNCWVQVEHFADEQTIPGIATKAH 218
            ...::....|..::|....|:    |:.....||...|:..            |..|| |:..|.
Worm    91 TSTSVKIGSLRISRCDVFNLFGPDLVKNVAVDNITPNFKFH------------ETPIP-ISEDAK 142

  Fly   219 VYLVADP----------HELPAEL--------TEVILSNYFN--TPRLMHRGHTYRIEVNAELVG 263
            :.|:..|          |.|...|        .:||....:|  |.:..|.  .|:::|::.
Worm   143 LSLMRQPSVAKNIRLEKHHLKQILKSANVFYKNDVIRITNYNAYTDKTTHL--FYKLDVSSS--- 202

  Fly   264 TATYAHYYLIFAHLRHVHLKCIHLETKGSEFELQAIVAKNFSNLVQVPASHSFLPRQVLDSMAIV 328
                               .|| :::..:.:|..|:..       .:|.|:..|...:..||
Worm   203 -------------------PCI-MDSSTAVYETSAVSQ-------SLPFSNFLLKNSLTSSM--- 237

  Fly   329 ENYPSGLRKPYKLLRSSVDAFLPKKSA--CLSSKHIFPVFLLQGERGSGKSKLVSAVAQELGMHI 391
                          |::|.......||  .:|.|.:  |.|:.|..||||..:....|.|...:.
Worm   238 --------------RTTVFRMTQIYSAQKTISKKAL--VLLVTGASGSGKRLMSRVFASETHRNF 286

  Fly   392 YGADCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFHNFEIFGIDNEGNEDLRLLSAFHVQVQE 456
            :..|..|:|.:..|.:|.|..:.:.|:::.:..::...|..:..||.....|.|:|.    .:::
Worm   287 FEVDGYEMVCENASTSEAKWTSWWEKAKLLQNCVLFIRNSNVLAIDQFNALDRRILQ----YMEQ 347

  Fly   457 LFNRDRKHPIVVVALTSDRHLKPM-IQGLFLEIINIDMPSKEERFEILRWMHVRETFNDIIYNQK 520
            ..:...|..::....|......|. ::.|.|...:.:...:.:          |:|:.....|:|
Worm   348 KLSEPSKITVIFSCNTDTMSSMPANVKNLALYTFSAEFMDEND----------RKTWLQYYLNEK 402

  Fly   521 AIEQLPLFSRENQSQFMPRISPSWRETLNVLQDVAAKSQGFLLGDLQLLYDNAVRMKIRNRLGRT 585
                                         :...||.|:.||.|.:|:.|..|..::||..:..:.
Worm   403 -----------------------------LANHVAKKTSGFTLAELEKLVKNGKKVKIEEKEEKV 438

  Fly   586 TLDMSHFAKNLTDMQSSFADSLGAPKVPKVYWSDIGGLAKLKDEIQSSIGLPLKHVHLMG-KNLR 649
            ..|:      :....|:|||::||||:|.|.|.|:|||.:.|..:..||     ..:|.| :.|:
Worm   439 YEDL------IDKRNSNFADAIGAPKIPNVRWEDVGGLEETKQTVLESI-----RTNLFGSRALK 492

  Fly   650 RSGILLYGPPGTGKTLVAKAVATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLF 714
            ||||:|||.||.||||:|||||||..::||||:||||||.||||||:|:|:||.||:.|:|||:|
Worm   493 RSGIILYGSPGCGKTLIAKAVATEFKIAFLSVKGPELLNKYVGQSEENLRKVFERAKQASPCVIF 557

  Fly   715 LDELDSLAPNRGVAGDSGGVMDRVVSQLLAEMDGMSDGDTSKPIFILAATNRPDLIDPALLRPGR 779
            .||:||||||||..||||||:||:|||||||:|.:.:...:| :|::.|||||||:|.:|:.|||
Worm   558 FDEIDSLAPNRGRNGDSGGVIDRIVSQLLAELDKLHNSPLTK-VFVMGATNRPDLLDNSLMTPGR 621

  Fly   780 FDKLFYVGPCSTAEDKAAVLRAQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRR 844
            ||||..|.|....|.|..:|.|.:::...:..||:.:||.::..:||||.|:||.|||.::|:..
Worm   622 FDKLVEVKPGEDVESKTKILEAVSRKMRFEEDVDLREIASKVDEKMSGAQLFSIISNAGMAAIVE 686

  Fly   845 TIDGHLSGTISEKELVPENVIVQEEDFTKSFNKF 878
            ||.     :|.:.:...:::.|.:....:|..:|
Worm   687 TIQ-----SIEDGKTENQSIRVAQRHLLESVKRF 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	176/481 (37%)
		P-loop_NTPase	367..492	CDD:304359	26/125 (21%)
		AAA	653..787	CDD:278434	88/133 (66%)
prx-6	NP_504268.1	CDC48	<261..714	CDD:273521	180/512 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164770
Domainoid	1	1.000	185	1.000	Domainoid score	I2020
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I1669
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233419at2759
OrthoFinder	1	1.000	-	-		FOG0004626
OrthoInspector	1	1.000	-	-		oto19528
orthoMCL	1	0.900	-	-		OOG6_103617
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R903
SonicParanoid	1	1.000	-	-		X3235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930