DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex6 and Vcp

DIOPT Version :9

Sequence 1:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_446316.1	Gene:	Vcp / 116643	RGDID:	621595	Length:	806	Species:	Rattus norvegicus

Alignment Length:	887	Identity:	246/887 - (27%)
Similarity:	386/887 - (43%)	Gaps:	212/887 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 KGKFLLTPI------PNRLYDLLIKNEQIKSEHLVFASQEVYENYAESPDVNFVNL------VIR 129
            ||..|.|.|      |||    ||.:|.|..::.|.:..:        |.::.:.|      :::
  Rat     8 KGDDLSTAILKQKNRPNR----LIVDEAINEDNSVVSLSQ--------PKMDELQLFRGDTVLLK 60

  Fly   130 GRRVRIGKPLASDEGNMTQTVIKQMLQEAPHTIVAQILPAAQCQPNCLYVQENFYGNILDRFQIR 194
            |::.|                      ||    |..:|....|....:.:..          .:|
  Rat    61 GKKRR----------------------EA----VCIVLSDDTCSDEKIRMNR----------VVR 89

  Fly   195 SNCWVQVEHFADEQTIPGI--ATKAHVYLVADPHE-LPAELTEVILSNYF-NTPRLMHRGHTYRI 255
            :|..|::......|..|.:  ..:.||..:.|..| :...|.||.|..|| ...|.:.:|
  Rat    90 NNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKG----- 149

  Fly   256 EVNAELVGTATYAHYYLIFAHLRHVHLKCIHLETKGSEFELQAIVAKNFSNLVQVPASHSFLPRQ 320
                         ..:|:...:|.|..|.:  ||..|.:   .|||.
  Rat   150 -------------DIFLVRGGMRAVEFKVV--ETDPSPY---CIVAP------------------ 178

  Fly   321 VLDSMAIVENYP------------------SGLRKPYKLLRSSVDAFLP-KKSACLSSKHIFPV- 365
              |::...|..|                  .|.||....::..|:  || :..|...:..:.|.
  Rat   179 --DTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVE--LPLRHPALFKAIGVKPPR 239

  Fly   366 -FLLQGERGSGKSKLVSAVAQELGMHIYGADCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFH 429
             .||.|..|:||:.:..|||.|.|...:..:..||:|::...:|..|:..|.:::...|.:|...
  Rat   240 GILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFID 304

  Fly   430 NFEIFGIDNE---GNEDLRLLSAFHVQVQELFNRDRKHPIVVVALTSDRHLKPMIQ--GLFLEII 489
            ..:......|   |..:.|::|.....:..|  :.|.|.||:.|......:.|.::  |.|...:
  Rat   305 ELDAIAPKREKTHGEVERRIVSQLLTLMDGL--KQRAHVIVMAATNRPNSIDPALRRFGRFDREV 367

  Fly   490 NIDMPSKEERFEILRWMHVRETFNDIIYNQKAIEQLPLFSRENQSQFMPRISPSWRETLNVLQDV 554
            :|.:|....|.|||: :|.:        |.|..:.:.                        |:.|
  Rat   368 DIGIPDATGRLEILQ-IHTK--------NMKLADDVD------------------------LEQV 399

  Fly   555 AAKSQGFLLGDLQLLYDNAVRMKIRNRLGRTTLD--------MSHFAKNLTDMQSSFADSLGAP- 610
            |.::.|.:..||..|...|....||.::....|:        |:..|..:.|.:.:.:.|..:.
  Rat   400 ANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSAL 464

  Fly   611 -----KVPKVYWSDIGGLAKLKDEIQSSIGLPLKHVHLMGKNLR-----RSGILLYGPPGTGKTL 665
                 :||:|.|.|||||..:|.|:|..:..|::|   ..|.|:     ..|:|.|||||.||||
  Rat   465 RETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEH---PDKFLKFGMTPSKGVLFYGPPGCGKTL 526

  Fly   666 VAKAVATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNR-GVAG 729
            :|||:|.||..:|:|::|||||.|:.|:||.||||:|.:||.|||||||.|||||:|..| |..|
  Rat   527 LAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIG 591

  Fly   730 DSGGVMDRVVSQLLAEMDGMSDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGPCSTAED 794
            |.||..|||::|:|.||||||   |.|.:||:.||||||:||||:|||||.|:|.|: |....:.
  Rat   592 DGGGAADRVINQILTEMDGMS---TKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI-PLPDEKS 652

  Fly   795 KAAVLRAQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHL--------- 850
            :.|:|:|..::..:...||:|.:| ::.:..|||||..||..|...|:|.:|:..:
  Rat   653 RVAILKANLRKSPVAKDVDLEFLA-KMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTN 716

  Fly   851 --SGTISEKELVPENVIVQEEDFTKSFNKFVPSISAKDLEYF 890
              :..:.|.:.|||   ::.:.|.::......|:|..|:..:
  Rat   717 PSAMEVEEDDPVPE---IRRDHFEEAMRFARRSVSDNDIRKY 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	177/504 (35%)
		P-loop_NTPase	367..492	CDD:304359	32/129 (25%)
		AAA	653..787	CDD:278434	86/134 (64%)
Vcp	NP_446316.1	CDC48	25..764	CDD:273521	239/870 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727		1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000250	797..806
		PIM motif. /evidence=ECO:0000250\|UniProtKB:P55072	802..806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910