Protein Alignment Pex6 and Vcp

DIOPT Version :10

• Sequence 1: NP_001027403.2
• Gene: Pex6 / 3772165
• FlyBaseID: FBgn0033564
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_446316.1
• Gene: Vcp / 116643
• RGDID: 621595
• Length: 806
• Species: Rattus norvegicus
• Alignment Length: 887
• Identity: 246/887 - (27%)
• Similarity: 386/887 - (43%)
• Gaps: 212/887 - (23%)

  Fly    77 KGKFLLTPI------PNRLYDLLIKNEQIKSEHLVFASQEVYENYAESPDVNFVNL------VIR 129
            ||..|.|.|      |||    ||.:|.|..::.|.:..:        |.::.:.|      :::
  Rat     8 KGDDLSTAILKQKNRPNR----LIVDEAINEDNSVVSLSQ--------PKMDELQLFRGDTVLLK 60

  Fly   130 GRRVRIGKPLASDEGNMTQTVIKQMLQEAPHTIVAQILPAAQCQPNCLYVQENFYGNILDRFQIR 194
            |::.|                      ||    |..:|....|....:.:..          .:|
  Rat    61 GKKRR----------------------EA----VCIVLSDDTCSDEKIRMNR----------VVR 89

  Fly   195 SNCWVQVEHFADEQTIPGI--ATKAHVYLVADPHE-LPAELTEVILSNYF-NTPRLMHRGHTYRI 255
            :|..|::......|..|.:  ..:.||..:.|..| :...|.||.|..|| ...|.:.:|
  Rat    90 NNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKG----- 149

  Fly   256 EVNAELVGTATYAHYYLIFAHLRHVHLKCIHLETKGSEFELQAIVAKNFSNLVQVPASHSFLPRQ 320
                         ..:|:...:|.|..|.:  ||..|.:   .|||.
  Rat   150 -------------DIFLVRGGMRAVEFKVV--ETDPSPY---CIVAP------------------ 178

  Fly   321 VLDSMAIVENYP------------------SGLRKPYKLLRSSVDAFLP-KKSACLSSKHIFPV- 365
              |::...|..|                  .|.||....::..|:  || :..|...:..:.|.
  Rat   179 --DTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVE--LPLRHPALFKAIGVKPPR 239

  Fly   366 -FLLQGERGSGKSKLVSAVAQELGMHIYGADCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFH 429
             .||.|..|:||:.:..|||.|.|...:..:..||:|::...:|..|:..|.:::...|.:|...
  Rat   240 GILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFID 304

  Fly   430 NFEIFGIDNE---GNEDLRLLSAFHVQVQELFNRDRKHPIVVVALTSDRHLKPMIQ--GLFLEII 489
            ..:......|   |..:.|::|.....:..|  :.|.|.||:.|......:.|.::  |.|...:
  Rat   305 ELDAIAPKREKTHGEVERRIVSQLLTLMDGL--KQRAHVIVMAATNRPNSIDPALRRFGRFDREV 367

  Fly   490 NIDMPSKEERFEILRWMHVRETFNDIIYNQKAIEQLPLFSRENQSQFMPRISPSWRETLNVLQDV 554
            :|.:|....|.|||: :|.:        |.|..:.:.                        |:.|
  Rat   368 DIGIPDATGRLEILQ-IHTK--------NMKLADDVD------------------------LEQV 399

  Fly   555 AAKSQGFLLGDLQLLYDNAVRMKIRNRLGRTTLD--------MSHFAKNLTDMQSSFADSLGAP- 610
            |.::.|.:..||..|...|....||.::....|:        |:..|..:.|.:.:.:.|..:.
  Rat   400 ANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSAL 464

  Fly   611 -----KVPKVYWSDIGGLAKLKDEIQSSIGLPLKHVHLMGKNLR-----RSGILLYGPPGTGKTL 665
                 :||:|.|.|||||..:|.|:|..:..|::|   ..|.|:     ..|:|.|||||.||||
  Rat   465 RETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEH---PDKFLKFGMTPSKGVLFYGPPGCGKTL 526

  Fly   666 VAKAVATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNR-GVAG 729
            :|||:|.||..:|:|::|||||.|:.|:||.||||:|.:||.|||||||.|||||:|..| |..|
  Rat   527 LAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIG 591

  Fly   730 DSGGVMDRVVSQLLAEMDGMSDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGPCSTAED 794
            |.||..|||::|:|.||||||   |.|.:||:.||||||:||||:|||||.|:|.|: |....:.
  Rat   592 DGGGAADRVINQILTEMDGMS---TKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI-PLPDEKS 652

  Fly   795 KAAVLRAQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHL--------- 850
            :.|:|:|..::..:...||:|.:| ::.:..|||||..||..|...|:|.:|:..:
  Rat   653 RVAILKANLRKSPVAKDVDLEFLA-KMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTN 716

  Fly   851 --SGTISEKELVPENVIVQEEDFTKSFNKFVPSISAKDLEYF 890
              :..:.|.:.|||   ::.:.|.::......|:|..|:..:
  Rat   717 PSAMEVEEDDPVPE---IRRDHFEEAMRFARRSVSDNDIRKY 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_001027403.2	SpoVK	<367..600	CDD:440232	55/245 (22%)
		RPT1	<609..883	CDD:440835	128/296 (43%)
Vcp	NP_446316.1	CDC48	25..764	CDD:273521	239/870 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	708..727		1/18 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000250	797..806
		PIM motif. /evidence=ECO:0000250|UniProtKB:P55072	802..806