DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33934 and PHO90

DIOPT Version :9

Sequence 1:	NP_001163660.1	Gene:	CG33934 / 3772159	FlyBaseID:	FBgn0064119	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_012337.1	Gene:	PHO90 / 853241	SGDID:	S000003734	Length:	881	Species:	Saccharomyces cerevisiae

Alignment Length:	550	Identity:	127/550 - (23%)
Similarity:	220/550 - (40%)	Gaps:	133/550 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KATAMIPLITLPIMIYGVLENNLAFQ--CMYLVANMALFWITEAIPLYLTALFPVVFLPLFGIL- 86
            ||..:..:|.:..::.|:...|.|.|  ||.||..:|..|.:|||||::||....:.:.||.:|
Yeast   413 KAYKIYFIILVTGLLLGIKTFNDAAQHRCMALVECVAFLWASEAIPLHITAFLVPLLVVLFKVLK 477

  Fly    87 -----------TSEKVCSFYFSDTVVMFIGGLLIALAIEYSNLHQRIALNTILIVGCSPRRLHFG 140
                       .|.::.:..:|.|:::.:.|..:...:...|:.:.:|...:...||.||.:
Yeast   478 TSDGAIMSAASASSEILAAMWSSTIMILLAGFTLGEVLAQYNIAKVLASWLLAFAGCKPRNV--- 539

  Fly   141 LVMVTC---FISLWISNSAATAMMCPIVKAVLNEMETQNIFAIYKTQEEEPVEEGDPPHPSTISM 202
            |:|..|   |:|:||||.||..:...::..:|:.|:..:.||                      .
Yeast   540 LLMAMCVVFFLSMWISNVAAPVLTYSLLSPLLDAMDADSPFA----------------------Q 582

  Fly   203 AFYFGIAYSSSIGGCGTLIGTGTN---LTYKGLYDTRFPNSDEKIDFPIFMAYSVP------FVV 258
            |...|:|.:::|||..:.|.:..|   ::|...|.         |.:..|.|.::|      .:|
Yeast   583 ALVLGVALAANIGGMSSPISSPQNIISMSYLKPYG---------IGWGQFFAVALPSGILAMLLV 638

  Fly   259 LVLIFLTYFSLQVTHMGLFRPNSKIGQEVKKGAESQDVVKDVIKQRKAELGPMSCHEIQVGLLFV 323
            .:|:|.| |.:..|.:..|:|       :|        .|..:||          :.|....:..
Yeast   639 WILLFTT-FKMNKTKLEKFKP-------IK--------TKFTVKQ----------YYIITVTVAT 677

  Fly   324 LMIFLLFTRKPGFFPGWADFLNAKAIGSGPPVFFATILLFALPTQYTFFKYCCGKAPFPGQTLDA 388
            ::::.:.::..|            |.||...:....|:||            .|......|.|:|
Yeast   678 ILLWCVESQIEG------------AFGSSGQIAIIPIVLF------------FGTGLLSTQDLNA 718

  Fly   389 CLSWVYCQKYTPFGLAFLLGGGFALAEGSRVSGMAKMLGESLAFAGEMHSVLVISMCI--IISLF 451
                      .|:.:..|..||.||.:....||:...:.::|....|...|..| :||  |:.|.
Yeast   719 ----------FPWSIVILAMGGIALGKAVSSSGLLSTIAKALQKKIENDGVFAI-LCIFGILMLV 772

  Fly   452 CTAFASNVAICNILIPIFSEMALAI---EVHPMKLTFPAALACSLAFHLPVSTPPN-AIISGFTG 512
            ...|.|:.....|:||:..|:...:   :..|: |.|..||..|....|..|..|| ..||....
Yeast   773 VGTFVSHTVSAIIIIPLVQEVGDKLGNPKAAPI-LVFGCALLSSCGMGLASSGFPNVTAISKVDR 836

  Fly   513 LKTKYMAI-----AGILPTCWAFLCLLFTG 537
            ...:|:::     .|:..:..||||::..|
Yeast   837 KGDRYLSVMTFLTRGVPASILAFLCVITLG 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33934	NP_001163660.1	dass	45..540	CDD:273267	122/529 (23%)
CG33934	NP_001163660.1	ArsB_NhaD_permease	52..524	CDD:304373	114/506 (23%)
PHO90	NP_012337.1	COG5408	1..288	CDD:227695
PHO90	NP_012337.1	SLC13_permease	442..870	CDD:238535	118/520 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343712
Domainoid	1	1.000	122	1.000	Domainoid score	I1235
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	85	1.000	Inparanoid score	I1587
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16868
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.820