Protein Alignment CG33934 and SLC13A1

DIOPT Version :10

• Sequence 1: NP_001163660.1
• Gene: CG33934 / 3772159
• FlyBaseID: FBgn0064119
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: XP_011514817.1
• Gene: SLC13A1 / 6561
• HGNCID: 10916
• Length: 651
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 197/647 - (30%)
• Similarity: 301/647 - (46%)
• Gaps: 148/647 - (22%)

  Fly    32 LITLPIMIYGVLENNLAFQCMYLVANMALFWITEAIPLYLTALFPVVFLPLFGILTSEKVCSFYF 96
            |:.||:.|  ||....| :|.|.:..:|.||:|||:||.:|||.|.:.||:|||:.|:||.|.||
Human    21 LVLLPLPI--VLHTKEA-ECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYF 82

  Fly    97 SDTVVMFIGGLLIALAIEYSNLHQRIALNTILIVGCSPRRLHFGLVMVTCFISLWISNSAATAMM 161
            .|..::.||.:.:|.:||..|||:||||..:::||.:|..|..|.:..|.|:|:|:||::..||:
Human    83 KDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMV 147

  Fly   162 CPIVKAVLNEM--------------------------ETQNIFAIYKTQEE-EPV---------- 189
            .||.:||:.::                          |:.|...|.:.:|: :||
Human   148 MPIAEAVVQQIINAEAEVEATQMTYFNGSTNHGLEIDESVNGHEINERKEKTKPVPGYNNDTGKI 212

  Fly   190 ----------EEGDPPHPST--------------------ISMAFYFG----------------- 207
                      ||.:.....|                    ::....||
Human   213 SSKVELEKEEEESNQQRVFTGSWVRKRMKLLLAYTLESHLLNKTLTFGLVIPQVKPFQDVPLSKN 277

  Fly   208 ----------------------IAYSSSIGGCGTLIGTGTNLTYKGLYDTRFPNSDEKIDFPIFM 250
                                  |||||:|||..|:.||.|||.:...::||:|:. ..::|..:.
Human   278 SGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDC-RCLNFGSWF 341

  Fly   251 AYSVPFVVLVLIFLTYFSLQVTHMGL-FRPNSKIGQEVKKGAESQDVVKDVIKQRKAELGPMSCH 314
            .:|.| ..|:::.|::..||...:|. |:...|.|   |.....|....:||||...:|||:...
Human   342 TFSFP-AALIILLLSWIWLQWLFLGFNFKEMFKCG---KTKTVQQKACAEVIKQEYQKLGPIRYQ 402

  Fly   315 EIQVGLLFVLMIFLLFTRKPGFFPGWADFLNAKAIGSGPPVFFATILLFALPTQYTFFKYCCGKA 379
            ||...:||::|..|.|:|.|||.|||:      |:.|..| .|||....||.....||.
Human   403 EIVTLVLFIIMALLWFSRDPGFVPGWS------ALFSEYP-GFATDSTVALLIGLLFFL------ 454

  Fly   380 PFPGQTL--------------DACLSWVYCQKYTPFGLAFLLGGGFALAEGSRVSGMAKMLGESL 430
             .|.:||              ...::|...|.:.|:.:|.|:|||||||:|...||::|.:|..|
Human   455 -IPAKTLTKTTPTGEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKL 518

  Fly   431 AFAGEMHS--VLVISMCIIISLFCTAFASNVAICNILIPIFSEMALAIEVHPMKLTFPAALACSL 493
            :..|.:.:  :::||..::.||  |..|||.|...:.:||.|.:|.||.|:|:.:..|:.|..|.
Human   519 SPLGSLPAWLIILISSLMVTSL--TEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSF 581

  Fly   494 AFHLPVSTPPNAIISGFTGLKTKYMAIAGILPTCWAFLCLLFTGTVWTMLIYPGTTEFPSWA 555
            ||.|||:.|||||:..:..||...|..||:.........::.....|.:.::...| :||||
Human   582 AFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYT-YPSWA 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33934	NP_001163660.1	ArsB_NhaD_permease	<32..165	CDD:473875	59/132 (45%)
		CitT	104..540	CDD:440239	158/558 (28%)
SLC13A1	XP_011514817.1	CitMHS	<7..171	CDD:460985	62/152 (41%)
		CitT	90..628	CDD:440239	158/558 (28%)