DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33934 and slc13a3

DIOPT Version :9

Sequence 1:	NP_001163660.1	Gene:	CG33934 / 3772159	FlyBaseID:	FBgn0064119	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_998067.1	Gene:	slc13a3 / 405838	ZFINID:	ZDB-GENE-040426-2486	Length:	596	Species:	Danio rerio

Alignment Length:	580	Identity:	182/580 - (31%)
Similarity:	273/580 - (47%)	Gaps:	79/580 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 MIPLITLPIMIYGVLENNLAFQCMYLVANMALFWITEAIPLYLTALFPVVFLPLFGILTSEKVCS 93
            :.||:.||::.....:..   :|:|:|..||::|.|||:||.:||:.||...|..|||.|:|||.
Zfish    21 LAPLLLLPLLFVVPPKEG---KCLYVVLLMAVYWCTEALPLAVTAMLPVCLFPTMGILPSKKVCP 82

  Fly    94 FYFSDTVVMFIGGLLIALAIEYSNLHQRIALNTILIVGCSPRRLHFGLVMVTCFISLWISNSAAT 158
            .||.:|..:|:.||::|.|||...||:||||..:.|||..|..|..|:::.:.|:|:|:||:|.|
Zfish    83 QYFLETNFLFLSGLVMASAIEEWGLHRRIALKVLKIVGVKPAWLILGMMITSSFLSMWLSNTATT 147

  Fly   159 AMMCPIVKAVLNEMETQNIFAIYKTQEEEPVEEGDPPHPSTISM--------------------- 202
            |||.||..|:|     :::|...:|.:|......||...|.:.|
Zfish   148 AMMLPIANAIL-----ESLFGNLETLKENCKTRSDPEGDSQVKMHVLPEKQILTVEDRPDWTDRS 207

  Fly   203 --------------------AFYFGIAYSSSIGGCGTLIGTGTNLTYKGLYDTRFPNSDEKIDFP 247
                                .|...|.|::||||..||.||..||...|...:.||..| .::|.
Zfish   208 EQRNQEEVRREAEYQMKVWKGFLICIPYAASIGGTATLTGTAPNLILVGQLKSYFPECD-LVNFG 271

  Fly   248 IFMAYSVPFVVLVLI-------FLTYFSLQVTHMGLFRPNSKIGQEVKKGAESQDVVKDVIKQRK 305
            .:..::.|.::|.||       || |..|. |.:.:.:.:.:...|.|..|        ||.:..
Zfish   272 SWFVFAFPLMLLFLILGWIWIAFL-YGGLN-TRLCISKNDERAAAEAKANA--------VIDEDY 326

  Fly   306 AELGPMSCHEIQVGLLFVLMIFLLFTRKPGFFPGWADFLNAKAIGSGPPVFFATILLFALPTQYT 370
            .:|||:...|..:...|::...|||||.|.|..||:.|.....:...........:||..|:|..
Zfish   327 KKLGPIKFAEGSIAFFFIIFAILLFTRDPKFVTGWSVFFPKGYVSDAVTGVIIISILFFFPSQRP 391

  Fly   371 ----FFKYCCGKAPFPGQTLDACLSWVYCQKYTPFGLAFLLGGGFALAEGSRVSGMAKMLGESLA 431
                :|.......|:.     ..|||...|:..|:.:..|||||||:|:|...||:|..:|..|.
Zfish   392 SLRWWFDSRASNTPYV-----PLLSWRKAQECVPWNIILLLGGGFAMAKGCEESGLAVWIGNHLQ 451

  Fly   432 FAGEMHSVLVISMCIIISLFC-TAFASNVAICNILIPIFSEMALAIEVHPMKLTFPAALACSLAF 495
            ...::...:.: |.|...:.| |.||||.|...|.:|:.:|:|:.::|:|:....||...||.||
Zfish   452 PLAQVPPPVAV-MLITAFIACFTEFASNTATIIIFLPVIAELAIRVKVNPLYFMIPATTGCSYAF 515

  Fly   496 HLPVSTPPNAIISGFTGLKTKYMAIAGILPTCWAFLCLLFTGTVWTMLIYPGTTEFPSWA 555
            .||||||||:|......|..|.|...|.:......||:......|.:.:: ....:|.||
Zfish   516 MLPVSTPPNSIAFASGHLMVKDMVKTGFVMNILGILCVSLAMNTWALHMF-NLHLYPDWA 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33934	NP_001163660.1	dass	45..540	CDD:273267	174/547 (32%)
CG33934	NP_001163660.1	ArsB_NhaD_permease	52..524	CDD:304373	171/524 (33%)
slc13a3	NP_998067.1	CitT	40..560	CDD:223547	174/541 (32%)
slc13a3	NP_998067.1	SLC13_permease	41..560	CDD:238535	173/540 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580409
Domainoid	1	1.000	381	1.000	Domainoid score	I793
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1908
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm6448
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.800