DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33934 and Indy

DIOPT Version :9

Sequence 1:	NP_001163660.1	Gene:	CG33934 / 3772159	FlyBaseID:	FBgn0064119	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	282/550 - (51%)
Similarity:	389/550 - (70%)	Gaps:	14/550 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RCCGF---HWRGKATAMIPLITLPIMIYGVLENNLAFQCMYLVANMALFWITEAIPLYLTALFPV 77
            :|..|   ||:|....::||:.||:|:   |.....|:||||:..||:||:|||:|||:|::.|:
  Fly    32 KCSNFFANHWKGLVVFLVPLLCLPVML---LNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPI 93

  Fly    78 VFLPLFGILTSEKVCSFYFSDTVVMFIGGLLIALAIEYSNLHQRIALNTILIVGCSPRRLHFGLV 142
            |..|:.||::|::.|..||.||:|||:||:::|||:||.|||:|:||..|.|||||||||||||:
  Fly    94 VAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLI 158

  Fly   143 MVTCFISLWISNSAATAMMCPIVKAVLNEMETQNIFAIYKTQEEEPV------EEGDPPHPSTIS 201
            |||.|:|:||||:|.|||||||::|||.|::.|.:..|....:.:.|      .|.:||:|:.|:
  Fly   159 MVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGVCKINHEPQYQIVGGNKKNNEDEPPYPTKIT 223

  Fly   202 MAFYFGIAYSSSIGGCGTLIGTGTNLTYKGLYDTRFPNSDEKIDFPIFMAYSVPFVVLVLIFLTY 266
            :.:|.||||:||:|||||:|||.||||:||:|:.||.||.|::|||.||.|||| .:||...||:
  Fly   224 LCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVP-SMLVYTLLTF 287

  Fly   267 FSLQVTHMGLFRPNSKIGQEVKKGAESQDVVKDVIKQRKAELGPMSCHEIQVGLLFVLMIFLLFT 331
            ..||...|||:||.||..|||::|.|..||.|.||.||..:|||||.|||||.:||:.|:.:.||
  Fly   288 VFLQWHFMGLWRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFT 352

  Fly   332 RKPGFFPGWADFLNAKAIGSGPPVFFATILLFALPTQYTFFKYCCGK-APFPGQTLDACLSWVYC 395
            ||||.|.||||.||:|.|.:..|..|..::.|.||..|.|.:||..: .|.|.....:.::|.:.
  Fly   353 RKPGIFLGWADLLNSKDIRNSMPTIFVVVMCFMLPANYAFLRYCTRRGGPVPTGPTPSLITWKFI 417

  Fly   396 QKYTPFGLAFLLGGGFALAEGSRVSGMAKMLGESLAFAGEMHSVLVISMCIIISLFCTAFASNVA 460
            |...|:||.|||||||||||||:.|||||::|.:|.....:.:.:::.:.|::::|.|||:||||
  Fly   418 QTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILVAVFLTAFSSNVA 482

  Fly   461 ICNILIPIFSEMALAIEVHPMKLTFPAALACSLAFHLPVSTPPNAIISGFTGLKTKYMAIAGILP 525
            |.||:||:.:||:||||:||:.|..||.||||:||||||||||||:::|:..::||.||||||.|
  Fly   483 IANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGIGP 547

  Fly   526 TCWAFLCLLFTGTVWTMLIYPGTTEFPSWA 555
            |....:.|......|.:::||....||.||
  Fly   548 TIITIITLFVFCQTWGLVVYPNLNSFPEWA 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33934	NP_001163660.1	dass	45..540	CDD:273267	264/501 (53%)
CG33934	NP_001163660.1	ArsB_NhaD_permease	52..524	CDD:304373	258/478 (54%)
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	257/477 (54%)
Indy	NP_730363.2	dass	70..545	CDD:273267	255/475 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448680
Domainoid	1	1.000	215	1.000	Domainoid score	I747
eggNOG	1	0.900	-	-		E1_COG0471
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I1174
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm6448
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	P	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
	10	9.790