DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33934 and Slc13a4

DIOPT Version :9

Sequence 1:	NP_001163660.1	Gene:	CG33934 / 3772159	FlyBaseID:	FBgn0064119	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_766480.1	Gene:	Slc13a4 / 243755	MGIID:	2442367	Length:	625	Species:	Mus musculus

Alignment Length:	612	Identity:	167/612 - (27%)
Similarity:	293/612 - (47%)	Gaps:	100/612 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 IPLITLPI-MIYGVLENNLAFQCMYLVANMALFWITEAIPLYLTALFPVVFLPLFGILTSEKVCS 93
            :||:.||: .||...|    ..|.|::...|::|::||:||...||.|....|.||:|.|.:|.:
Mouse    19 VPLLLLPLPTIYPTSE----AACAYVLLVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSSEVAA 79

  Fly    94 FYFSDTVVMFIGGLLIALAIEYSNLHQRIALNTILIVGCSPRRLHFGLVMVTCFISLWISNSAAT 158
            .||.:|.::.:|.:.:|.|:|..|||:||||..:|:.|..|..|....:..|..:|:|:||::.|
Mouse    80 EYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTMLSMWLSNTSTT 144

  Fly   159 AMMCPIVKAVLNE-----------------------------------------------METQN 176
            ||:.|||:|||.|                                               |:::|
Mouse   145 AMVMPIVEAVLQELINAEEEQLAAGTEEAELMGLDVNNRQTSMELIFVNEDTSAADFTSLMQSKN 209

  Fly   177 IFAI------------YKTQEEEPVEE--GDPP----------------HPSTISMAFYFGIAYS 211
            :..:            .:.::::|.:|  |.|.                |...|.......|:|:
Mouse   210 LNGVPMVTKSINTANQQQQKKQQPSQEKPGVPTPSSKTQELNKKKYRSHHDQMICKCLSLSISYA 274

  Fly   212 SSIGGCGTLIGTGTNLTYKGLYDTRFPNSDEKIDFPIFMAYSVPFVVLVLIFLTYFSLQVTHMGL 276
            ::|||..|:|||.|:|.:...::.::| :.|.::|..:..:|.| :.|:::.:::|.:....:|.
Mouse   275 ATIGGLTTIIGTSTSLIFLEHFNNQYP-AAEVVNFGTWFLFSFP-ISLIMLVVSWFWIHWLFLGC 337

  Fly   277 -FRPNSKIGQEVKKGAESQDVVKDVIKQRKAELGPMSCHEIQVGLLFVLMIFLLFTRKPGFFPGW 340
             |:....:.:  ||....:::.:..|::...:||.:|..|:.....|:||..|.|||:|||.|||
Mouse   338 NFKETCSLSK--KKKTRREELSEKRIREEYEKLGDISYPEMVTAFFFILMTVLWFTREPGFVPGW 400

  Fly   341 ADFLNAKAIGSGPPV-FFATILLFALPTQYTFFKYCCG-KAPFPGQT----LDACLSWVYCQKYT 399
            ..|...|...:...| .|...|||.:|.:    |.|.| |:...||.    ::..::|...||..
Mouse   401 DSFFEKKGYRTDATVSVFLGFLLFLIPAK----KPCFGKKSDGTGQEASKGIEPIITWKDFQKTM 461

  Fly   400 PFGLAFLLGGGFALAEGSRVSGMAKMLG-ESLAFAGEMHSVLVISMCIIISLFCTAFASNVAICN 463
            |:.:..|:|||:|||.||:.||::..:| :.|:.:......:.:..|:::|: .|.|.||.|...
Mouse   462 PWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSI-VTEFVSNPATIT 525

  Fly   464 ILIPIFSEMALAIEVHPMKLTFPAALACSLAFHLPVSTPPNAIISGFTGLKTKYMAIAGILPTCW 528
            |.:||...::..:.::|:....|..::.|.|..|||..|||||:..:...:.|.|..||:.....
Mouse   526 IFLPILCTLSETLHINPLYTLVPVTMSISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVI 590

  Fly   529 AFLCLLFTGTVWTMLIYPGTTEFPSWA 555
            ..:.::.....|.:.:: ....||:||
Mouse   591 GLVIVMVAINTWGVSLF-HLDAFPAWA 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33934	NP_001163660.1	dass	45..540	CDD:273267	155/579 (27%)
CG33934	NP_001163660.1	ArsB_NhaD_permease	52..524	CDD:304373	154/556 (28%)
Slc13a4	NP_766480.1	ArsB_NhaD_permease	31..607	CDD:304373	157/588 (27%)
Slc13a4	NP_766480.1	dass	40..602	CDD:273267	153/570 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836897
Domainoid	1	1.000	383	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1967
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8724
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.860