DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33934 and Slc13a2

DIOPT Version :9

Sequence 1:	NP_001163660.1	Gene:	CG33934 / 3772159	FlyBaseID:	FBgn0064119	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_071856.1	Gene:	Slc13a2 / 20500	MGIID:	1276558	Length:	586	Species:	Mus musculus

Alignment Length:	573	Identity:	220/573 - (38%)
Similarity:	313/573 - (54%)	Gaps:	72/573 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 IPLITLPIMIYGVLENNLAFQCMYLVANMALFWITEAIPLYLTALFPVVFLPLFGILTSEKVCSF 94
            :|:..||:.:  :::...|: |.|.:..|||.|.|||:||.:|||||::..||.||:.:.|||..
Mouse    20 LPIFLLPLPL--IVQTKEAY-CAYSIILMALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLE 81

  Fly    95 YFSDTVVMFIGGLLIALAIEYSNLHQRIALNTILIVGCSPRRLHFGLVMVTCFISLWISNSAATA 159
            ||.||.::|:|||::|:|:|:.|||:||||..:||:|..|..|..|.::||.|:|:||||:|.||
Mouse    82 YFKDTNILFVGGLMVAIAVEHWNLHKRIALGVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTA 146

  Fly   160 MMCPIVKAVLNEM-------ETQNIFAIYKTQEEEPVEE-------------GDPPHPST----- 199
            ||.||..|||.::       |..|....::.||..|.:|             .:|....|
Mouse   147 MMLPIGYAVLEQLQGSQKDVEEGNSNPSFELQEASPQKEETKLDNGQAVSVSSEPRAQKTKEHHR 211

  Fly   200 ISMAFYFGIAYSSSIGGCGTLIGTGTNLTYKGLYDTRFPNSDEKIDFPIFMAYSVPFVVLVLIFL 264
            .|......|.||:||||..||.||..||..:|..::.||.:...::|..:..::.|.:| :|:.|
Mouse   212 FSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFPENSNVVNFASWFGFAFPTMV-ILLLL 275

  Fly   265 TYFSLQVTHMGL-FRPNSKI--GQEVKKGAESQDVVKDVIKQRKAELGPMSCHEIQVGLLFVLMI 326
            .:..|||..:|: ||.|...  |:|.:|.|..|     |||.:...|||||..|..|..||||::
Mouse   276 AWLWLQVLFLGVNFRKNFGFGEGEEERKQAAFQ-----VIKTQHRLLGPMSFAEKAVTFLFVLLV 335

  Fly   327 FLLFTRKPGFFPGWAD--FLNAKA---IGSGPPVFFATILLFALPTQYTFFKYCCGKAPFPGQTL 386
            .|.|||:|||||||.|  |.|.|.   :..|....|.::::|.:|::            .||.|.
Mouse   336 VLWFTREPGFFPGWGDTAFANKKGQSMVSDGTVAIFISLIMFIIPSK------------IPGLTE 388

  Fly   387 D-----------ACLSWVYCQKYTPFGLAFLLGGGFALAEGSRVSGMAKMLGESLA---FAGEMH 437
            |           |.|:|.......|:.:..|||||||||:||..||::|.||:.|.   ......
Mouse   389 DPKKPGKLKAPPAILTWKTVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTPLQHVPPSA 453

  Fly   438 SVLVISMCIIISLFCTAFASNVAICNILIPIFSEMALAIEVHPMKLTFPAALACSLAFHLPVSTP 502
            :||::|:.:.|...||   ||||...:.:||.:.||.||.:||:.:..|..||.||||.|||:||
Mouse   454 TVLILSLLVAIFTECT---SNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFMLPVATP 515

  Fly   503 PNAIISGFTGLKTKYMAIAGILPTCWAFLCLLFTGTVWTMLIYPGTTEFPSWA 555
            ||||:..|.|||...||.||.|......|.:..:...|::.|:...| ||:||
Mouse   516 PNAIVFSFGGLKVSDMARAGFLLNIIGVLTITLSINSWSIPIFKLDT-FPTWA 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33934	NP_001163660.1	dass	45..540	CDD:273267	210/541 (39%)
CG33934	NP_001163660.1	ArsB_NhaD_permease	52..524	CDD:304373	206/518 (40%)
Slc13a2	NP_071856.1	ArsB_NhaD_permease	6..560	CDD:304373	215/563 (38%)
		dass	43..553	CDD:273267	207/530 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..209		8/43 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836894
Domainoid	1	1.000	383	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1967
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8724
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800