DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33934 and nac-1

DIOPT Version :9

Sequence 1:	NP_001163660.1	Gene:	CG33934 / 3772159	FlyBaseID:	FBgn0064119	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_510473.2	Gene:	nac-1 / 181585	WormBaseID:	WBGene00003517	Length:	582	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	174/569 - (30%)
Similarity:	288/569 - (50%)	Gaps:	67/569 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LITLPIMIYGVLENNLAFQCMYLVANMALFWITEAIPLYLTALFPVVFLPLFGILTSEKVCSFYF 96
            ||..|::::....:.|..:|:|.||.|..:|:.||:||.:||..|::..|||||:.||:|...|.
Worm    25 LIFSPLLMFVGDSHGLQAKCLYCVAVMGSYWVFEALPLAITAFIPMILFPLFGIMRSEEVARAYL 89

  Fly    97 SDTVVMFIGGLLIALAIEYSNLHQRIALNTILIVGCSPRRLHFGLVMVTCFISLWISNSAATAMM 161
            .||..:|:|||::|||:|...||.|:||..:..||..|.|:..|.:.||.|:|:||||:|.||:|
Worm    90 PDTCFLFMGGLMVALAVEKCELHARVALFVLKTVGSEPARVMAGFMGVTGFLSMWISNTATTALM 154

  Fly   162 CPIVKAVLNEM----ETQNIFAIYKTQ-----------------------EEEPVEEGDPPHPST 199
            .||:::|:.|:    ..:::.|:.:..                       :.|.::....|....
Worm   155 VPILQSVITELVSNHRMEDLVALCEAHHNSSRKHSVGMRRLSLPNENNEIKREEMDTAMSPREQK 219

  Fly   200 ISMAFYFGIAYSSSIGGCGTLIGTGTNLTYKGLYDTRFPNSDEKIDFPIFMAYSVPFVVLVLIFL 264
            ::......:.:|::|||..|:.||.:||...|..:..||.:|..::|..::.::.|.|...||:
Worm   220 MAKGLMLSVCFSANIGGAATITGTASNLVLVGQLNELFPGADTGVNFLSWLIFAFPMVFCCLIY- 283

  Fly   265 TYFSLQVTHMGLFRPNSKIGQEVKKGAESQDVVKDVIKQRKAELGPMSCHEIQVGLLFVLMIFLL 329
            .:..|.:.::          ::..||:   .:|...::|:..||...|..|:.|...|.|::.|.
Worm   284 CWCVLYLLYL----------RDAPKGS---IIVTRKLQQKYNELHAFSFAEMAVIFCFALLLVLW 335

  Fly   330 FTRKPGFFPGWADFLNAKAIGSGPPVFFATILLFALPTQYTFFKYCCGKAPFPGQTLDACLSWVY 394
            ..|:|...|||.:....:.:.......|..||||.||.:....:....:.......||    |..
Worm   336 ILREPQVVPGWGEMFKDEFVSDATSAMFIVILLFTLPEKLPSSRGSSEQRKASSGLLD----WAT 396

  Fly   395 CQKYTPFGLAFLLGGGFALAEGSRVSGMAKMLGESLAFAGEMHSVLVISMCIIISLFCTAFASNV 459
            .|...|:.:.||||||||||.|.:.||::..:|..:.:....:..:::.:|||||:..|...||.
Worm   397 VQDRFPWSVLFLLGGGFALAAGVKESGLSHDIGAIMRYLDVFNHNIIMLICIIISVTLTNVCSNT 461

  Fly   460 AICNILIPIFSEMALAIEVHPMKLTFPAALACSLAFHLPVSTPPNAII--SGFTGLKTKYMAIAG 522
            .|.:|.|||.:|:|.::|:.|:....|..::.|.||.|||:||||||:  ||:  ||...|.::|
Worm   462 VIASIFIPIVAELARSLEIDPLNFMLPVTISASFAFLLPVATPPNAIVFSSGY--LKVFDMFVSG 524

  Fly   523 ILPTCWAFLC--------LLFTGTVWTMLIYPGTTEFPS-------WAI 556
            :   |....|        ||:.|.|:.:.::|.....||       ||:
Worm   525 L---CVTLGCVVLSMLNMLLWAGFVFNLHLFPQWAANPSPPLDVQDWAV 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33934	NP_001163660.1	dass	45..540	CDD:273267	165/531 (31%)
CG33934	NP_001163660.1	ArsB_NhaD_permease	52..524	CDD:304373	158/500 (32%)
nac-1	NP_510473.2	CitT	19..547	CDD:223547	168/544 (31%)
nac-1	NP_510473.2	SLC13_permease	45..544	CDD:238535	162/521 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I685
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I1442
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm4842
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.870