DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33934 and Slc13a3

DIOPT Version :9

Sequence 1:	NP_001163660.1	Gene:	CG33934 / 3772159	FlyBaseID:	FBgn0064119	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_473396.1	Gene:	Slc13a3 / 114644	MGIID:	2149635	Length:	600	Species:	Mus musculus

Alignment Length:	584	Identity:	199/584 - (34%)
Similarity:	292/584 - (50%)	Gaps:	84/584 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 MIPLITLPIMIYGVLENNLAFQCMYLVANMALFWITEAIPLYLTALFPVVFLPLFGILTSEKVCS 93
            ::||..|||:.....:..   :|:|::..||::|.|||:||.:|||.|::..|..|||.|.|||.
Mouse    22 LVPLALLPILFALPPKEG---RCLYVILLMAVYWCTEALPLSVTALLPIILFPFMGILPSSKVCP 83

  Fly    94 FYFSDTVVMFIGGLLIALAIEYSNLHQRIALNTILIVGCSPRRLHFGLVMVTCFISLWISNSAAT 158
            .||.||..:|:.||::|.|||..|||:||||..:::||..|.||..|:::.|.|:|:|:||:|:|
Mouse    84 QYFLDTNFLFLSGLIMASAIEEWNLHRRIALKVLMLVGVQPARLILGMMVTTSFLSMWLSNTAST 148

  Fly   159 AMMCPIVKAVLNEMETQNIFAIYKTQEEEP--------------------------------VEE 191
            |||.||..|:|     :::|...:.:::.|                                .|:
Mouse   149 AMMLPIASAIL-----KSLFGQREARKDLPREGDESTAAVQGNGLRTVPTEMQFLASSEGGHTED 208

  Fly   192 GDPP-----------HPSTISMAFYFGIAYSSSIGGCGTLIGTGTNLTYKGLYDTRFPNSDEKID 245
            .:.|           |...|...|...|.||:||||..||.||..||...|...:.||..| .::
Mouse   209 AEAPMELPDDSKEEEHRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCD-VVN 272

  Fly   246 FPIFMAYSVPFVVLVLIFLTYFSLQVTHM-GLFRPNSKIGQEVKKGAESQDVVKDVIKQRKAELG 309
            |..:..::.|   |:|:||....|.::.: |.....|...::.|..|:::|..|.||::....||
Mouse   273 FGSWFIFAFP---LMLLFLLVGWLWISFLYGGMSWRSWRKKKSKIRADAEDQAKAVIQEEFQNLG 334

  Fly   310 PMSCHEIQVGLLFVLMIFLLFTRKPGFFPGWAD-----FLNAKAIGSGPPVFFATILLFALPTQY 369
            |:...|..|.:||.....|||:|.|.|.||||.     |::....|    |...|||.| .|:|.
Mouse   335 PIKFAEQAVFILFCTFAILLFSRDPKFIPGWASLFAPGFVSDAVTG----VAIVTILFF-FPSQK 394

  Fly   370 TFFKYCCG-KAPFPGQTLDACLSWVYCQKYTPFGLAFLLGGGFALAEGSRVSGMAKMLGESLAFA 433
            ...|:... ||  |....:..|||...|:..|:.:..|||||||:|:|...||::..:|
Mouse   395 PSLKWWFDFKA--PNSETEPLLSWKKAQETVPWNIILLLGGGFAMAKGCEESGLSAWIG------ 451

  Fly   434 GEMH------SVLVISMCIIISLFCTAFASNVAICNILIPIFSEMALAIEVHPMKLTFPAALACS 492
            |::|      .:|.:.:..::..|.|.||||.|...|.:|:.:|:|:.:.|||:.|..|..:.||
Mouse   452 GQLHPLEHVPPLLAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLHVHPLYLMIPGTVGCS 516

  Fly   493 LAFHLPVSTPPNAIISGFTGLKTKYMAIAGILPTCWAFLCLLFTGTVWTMLIYP-GTTEFPSWA 555
            .||.||||||||:|......|..|.|...|:|......|.|......|...|:. ||  ||.||
Mouse   517 YAFMLPVSTPPNSIAFSTGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGT--FPDWA 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33934	NP_001163660.1	dass	45..540	CDD:273267	186/550 (34%)
CG33934	NP_001163660.1	ArsB_NhaD_permease	52..524	CDD:304373	182/527 (35%)
Slc13a3	NP_473396.1	dass	31..565	CDD:273267	186/558 (33%)
Slc13a3	NP_473396.1	SLC13_permease	42..556	CDD:238535	183/535 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836885
Domainoid	1	1.000	383	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1967
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8724
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.800