DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33934 and slc13a5b

DIOPT Version :9

Sequence 1:	NP_001163660.1	Gene:	CG33934 / 3772159	FlyBaseID:	FBgn0064119	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	XP_001345110.4	Gene:	slc13a5b / 100006328	ZFINID:	ZDB-GENE-130530-605	Length:	580	Species:	Danio rerio

Alignment Length:	580	Identity:	200/580 - (34%)
Similarity:	305/580 - (52%)	Gaps:	80/580 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PLITLPIMIYGVLENNLAFQCMYLVANMALFWITEAIPLYLTALFPVVFLPLFGILTSEKVCSFY 95
            |||.||:.:  |:....| .|.|::..||::|.|||:||.:|:|.|.|..|:.||:.|:.||..|
Zfish    21 PLILLPLPL--VISTREA-SCAYVIILMAVYWCTEALPLAVTSLLPAVLFPMLGIMQSKMVCMQY 82

  Fly    96 FSDTVVMFIGGLLIALAIEYSNLHQRIALNTILIVGCSPRRLHFGLVMVTCFISLWISNSAATAM 160
            ..||.::|:|||::|:|:|:.|||:||||..:||||..|..|..|.:.||.|:|:||||:|.|||
Zfish    83 LKDTNMLFVGGLMVAVAVEHWNLHKRIALRVLLIVGVRPALLMLGFMGVTAFLSMWISNTATTAM 147

  Fly   161 MCPIVKAVLNEMETQNIFAIYKTQEEEPVE-----------EGDPPHPST--------------- 199
            |.|||:|||.::         ..||.||::           |.:..|.:.
Zfish   148 MVPIVQAVLEQL---------NKQETEPLQMTCGVERPRTPEAEYKHAAKDRDRQVVLRMLDVSP 203

  Fly   200 ------------ISMAFYFGIAYSSSIGGCGTLIGTGTNLTYKGLYDTRFPNSDEKIDFPIFMAY 252
                        ::......:.|::|:||..||.|||.||..||..:..||.:.:.|:|..:..:
Zfish   204 EVRQKELAEKRHMAKGMTLCVCYAASVGGTATLTGTGPNLVLKGQMNQLFPENGDVINFASWFGF 268

  Fly   253 SVPFVVLVLIFLTYFSLQVTHMGLFRPNSKIGQEVKKGAESQDVVKDVIKQRKAELGPMSCHEIQ 317
            :.|.::::|. :.:..||...|| |......|....| :|.:....:||:::..:||||...|:.
Zfish   269 AFPNMIIMLT-IAWLYLQFIFMG-FNIRKTWGCGAVK-SEKEIAAYNVIREQHLQLGPMCFGELS 330

  Fly   318 VGLLFVLMIFLLFTRKPGFFPGWADF---LNAKAIGSGPPVFFATILLFALPTQ--YTFFKYCCG 377
            |..||.|::.|.|||.|||..|||..   :.|:.:.......|..:|||.||::  ...|....|
Zfish   331 VLALFSLLVALWFTRDPGFVAGWATHTFNIEAEYVTDATVAVFIAMLLFVLPSKPPQLCFSSSTG 395

  Fly   378 ------KAPFPGQTLDACLSWVYCQKYTPFGLAFLLGGGFALAEGSRVSGMAKMLGESLAFAGEM 436
                  ::..||..|   |||...||..|:.:..|||||||||:||..||:::.||..|.   .:
Zfish   396 SETESQRSSAPGTAL---LSWKVAQKKLPWNIVLLLGGGFALAKGSEESGLSRWLGNQLT---PL 454

  Fly   437 HSV----LVISMCIIISLF--CTAFASNVAICNILIPIFSEMALAIEVHPMKLTFPAALACSLAF 495
            ||:    :||.:|::|::|  ||   ||||...:.:|:.:.|:.::.::|:.:..|..|:.|.||
Zfish   455 HSIPPWAVVIILCLLIAIFTECT---SNVATATLFLPVLASMSQSVGINPLYIMVPCTLSASFAF 516

  Fly   496 HLPVSTPPNAIISGFTGLKTKYMAIAGILPTCWAFLCLLFTGTVWTMLIYPGTTEFPSWA 555
            .|||:||||||:..:..||...||..||:.......|:......|...:: ....||:||
Zfish   517 MLPVATPPNAIVFSYGYLKVSDMAKTGIMMNIIGIFCITLAINTWGKAMF-NLDSFPAWA 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33934	NP_001163660.1	dass	45..540	CDD:273267	189/549 (34%)
CG33934	NP_001163660.1	ArsB_NhaD_permease	52..524	CDD:304373	185/526 (35%)
slc13a5b	XP_001345110.4	ArsB_NhaD_permease	31..568	CDD:304373	190/559 (34%)
slc13a5b	XP_001345110.4	CitT	36..561	CDD:223547	189/546 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580406
Domainoid	1	1.000	381	1.000	Domainoid score	I793
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1908
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm6448
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900