DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and ADAM7

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_016869432.1	Gene:	ADAM7 / 8756	HGNCID:	214	Length:	755	Species:	Homo sapiens

Alignment Length:	717	Identity:	221/717 - (30%)
Similarity:	325/717 - (45%)	Gaps:	110/717 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVV-VDLQRNDLLLPNSHFLRYQNAS 116
            ::||:         .|..:...|..||....:..|:|.:.:. :.|.|..|:|   |.||    |
Human    29 LVRPK---------KLPLIQKRDTGHTHDDDILKTYEEELLYEIKLNRKTLVL---HLLR----S 77

  Fly   117 RGATPGHVVTTFTKTE----------VDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYF 171
            |.....:...||...:          :|.|.|||.|..:.:|..::|||:|
Human    78 REFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCNG-------------- 128

  Fly   172 IHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLD- 235
                :.|..|:.|..||::..            .:.|:..|...|.:             ||:.
Human   129 ----LRGFFRINDQRYLIEPV------------KYSDEGEHLVFKYN-------------LRVPY 164

  Fly   236 GGEFSRTLL---RKRRQADDSSQ---LIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQY 294
            |..:|.|.|   ||....|:.|:   .|:|.::    ..||||.||.|:.||:.......|:...
Human   165 GANYSCTELNFTRKTVPGDNESEEDSKIKGIHD----EKYVELFIVADDTVYRRNGHPHNKLRNR 225

  Fly   295 CKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQL 359
            ..|:.|.:|.:|..|||.|.|||:.||...::||..|:.:.||..|..::...|......|:..|
Human   226 IWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVL 290

  Fly   360 LTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDE 424
            |:.:.....|.|.:..|.:|...||..:.....|:..::|..|||::|||.||:||...|.|...
Human   291 LSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSG 355

  Fly   425 KCVMAASSTSFIP-VNWSSCSIDQLTIAFSRGMNYCLRN--KPERLFESPTCGNGFVEPGEQCDC 486
            ||||  .|...|| :.:|.||.:|...........|:.|  .|....:...|||..::.||:|||
Human   356 KCVM--DSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDC 418

  Fly   487 GLPEHCENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYC 551
            |..:.|.|.||:|.||:| ....|||.||||:  :|:.|.|||.||.|::|||.||.|||.|..|
Human   419 GPAQECTNPCCDAHTCVL-KPGFTCAEGECCE--SCQIKKAGSICRPAKDECDFPEMCTGHSPAC 480

  Fly   552 PADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTG-DNSEHCYNKNTEGTRLGNCGYNRLN 615
            |.|.||.:..||...:.|||.|.|.:..:||..|:.... ::.:.||..||:|.:.|.| .|:.|
Human   481 PKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYKMNTKGNKFGYC-KNKEN 544

  Fly   616 KTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISH-----DRKIVACRTALVDLGLQT 675
            : ||.|||:.|.||.::|.        |.|.:::|......|     ....|.|:|  :.|...:
Human   545 R-FLPCEEKDVRCGKIYCT--------GGELSSLLGEDKTYHLKDPQKNATVKCKT--IFLYHDS 598

  Fly   676 TDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESC 740
            ||.||..:|.|||...:|.:..||.::.|.   :...||..||.|.:......|||:.|....:|
Human   599 TDIGLVASGTKCGEGMVCNNGECLNMEKVY---ISTNCPSQCNENPVDGHGLQCHCEEGQAPVAC 660

  Fly   741 SK 742
            .:
Human   661 EE 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	28/120 (23%)
		Reprolysin	269..464	CDD:279729	66/197 (34%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	65/193 (34%)
		Disintegrin	479..555	CDD:278623	40/75 (53%)
		ACR	558..701	CDD:214743	47/148 (32%)
ADAM7	XP_016869432.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6917
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920