DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and ADAM9

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_016869431.1	Gene:	ADAM9 / 8754	HGNCID:	216	Length:	821	Species:	Homo sapiens

Alignment Length:	956	Identity:	281/956 - (29%)
Similarity:	425/956 - (44%)	Gaps:	183/956 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPLLL---LNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRP---QVEHGRTKRSL 67
            ||.|.   ||..::...::....::|.|:           ...|:|.:|.|   ..|.....|.
Human    11 LPTLAHWGLNFSVRFGEVKHTNCSSFQQT-----------SHLSSYEIITPWRLTRERREAPRP- 63

  Fly    68 LTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTE 132
                      ::.|:|.....|||..::.|:||..|||....:...|..     |.::|.....:
Human    64 ----------YSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKE-----GTLITDHPNIQ 113

  Fly   133 VDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQD----DHYLLKQAD 193
             :.|||:|::.|...|.:|||.|.| |.|::.....:|.|.|       ||:    :|.:.:..|
Human   114 -NHCHYRGYVEGVHNSSIALSDCFG-LRGLLHLENASYGIEP-------LQNSSHFEHIIYRMDD 169

  Fly   194 MHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIR 258
            ::.....||..|      .|.||                        .|...:..:....:||:|
Human   170 VYKEPLKCGVSN------KDIEK------------------------ETAKDEEEEPPSMTQLLR 204

  Fly   259 GPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNE 323
            ........:.||||.||||.:.|.....|...|.:....:||.::::|:.|||.:.|||:.||..
Human   205 RRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTN 269

  Fly   324 SNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVS 388
            .|.|.........|.||:.:|...|:....:|:|||:.|:.| ||..|.|..|.:|:..::||::
Human   270 GNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGF-GGTAGMAFVGTVCSRSHAGGIN 333

  Fly   389 MQHSPNPAMVATTMAHEMGHNFGMEHDTS-DCHCRDEKCVMAASSTSFIPVNWSSCS---IDQLT 449
            :.........|:.:|||:|||.||.||.. ||.|..:.|:|.:.::.  ..|:||||   .::||
Human   334 VFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSGASG--SRNFSSCSAEDFEKLT 396

  Fly   450 IAFSRGMNYCLRN--KPERLFESPTCGNGFVEPGEQCDCGLPEHCE-NACCNAQTCMLHSKNATC 511
            :  ::|.| ||.|  ||:..:.:|:|||..|:.||:||||.|:.|| :.||...||.|.| .|.|
Human   397 L--NKGGN-CLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKS-FAEC 457

  Fly   512 ATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCR 576
            |.|:||  ..||....|:.||...:|||:||||.|.|::|..|||.::..||...:|||::|.|:
Human   458 AYGDCC--KDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQ 520

  Fly   577 SHSNQCRTLWGPTGDNS-EHCY-NKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNER 639
            .:..||:.::|.....: :.|: ..|::|.|.||||::  ...:.:|...:..||.|.|.::.|.
Human   521 YYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFS--GNEYKKCATGNALCGKLQCENVQEI 583

  Fly   640 LEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDA- 703
            ..||:..|.:.:.|      :...|......||....|||:...|.|||..|:|.:.:|  |||
Human   584 PVFGIVPAIIQTPS------RGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQC--VDAS 640

  Fly   704 -------VRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSV 761
                   |::|         |:|:|:|||..:|||:.|:...:|...|.|||.|||| |....:.
Human   641 VLNYDCDVQKK---------CHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGP-TYNEMNT 695

  Fly   762 GFKRFLYVLFFFVLPVV--ALFWFLYHCYKNGMLTRG---KLADNILKSSGGSKPITTRTNQNGT 821
            ..:..|.|.||.::|::  |:|.|:    |...|.|.   |......:|.|          :|..
Human   696 ALRDGLLVFFFLIVPLIVCAIFIFI----KRDQLWRSYFRKKRSQTYESDG----------KNQA 746

  Fly   822 GPPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAF 886
            .|....|   |.|...         ||                 :.|..:....|:.:..|..|.
Human   747 NPSRQPG---SVPRHV---------SP-----------------VTPPREVPIYANRFAVPTYAA 782

  Fly   887 VQPTVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPEATWVRPAPALP 932
            .||   |..|.|..||.|.|          |.:......|||||.|
Human   783 KQP---QQFPSRPPPPQPKV----------SSQGNLIPARPAPAPP 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	30/109 (28%)
		Reprolysin	269..464	CDD:279729	71/200 (36%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	70/196 (36%)
		Disintegrin	479..555	CDD:278623	36/76 (47%)
		ACR	558..701	CDD:214743	41/144 (28%)
ADAM9	XP_016869431.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9321
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1788
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41556
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.970