DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and ADAM15

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_997080.1	Gene:	ADAM15 / 8751	HGNCID:	193	Length:	863	Species:	Homo sapiens

Alignment Length:	1007	Identity:	303/1007 - (30%)
Similarity:	450/1007 - (44%)	Gaps:	192/1007 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFLLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTT 70
            |:.|.||...:.|....|.....|...|:|.||:...|          :.|||.......||...
Human     6 LWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREP----------LEPQVLQDDLPISLKKV 60

  Fly    71 LDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFL-RYQ-NASRGATPGHVVTTFTKTEV 133
            |..:  |..| :.:....:|...:::|.:|..|:|....| .|| :.:|..:.||.        :
Human    61 LQTS--LPEP-LRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHT--------L 114

  Fly   134 DLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTN 198
            :.|.|||.:||...|.|::.||.|....:|:...::|.:.   .|.|.||....:.:..|:|...
Human   115 ENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLE---QGPGDLQGPPIISRIQDLHLPG 176

  Fly   199 ATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNA 263
            .||........|:   :|.          |..||       .:..:|:||.....::.
Human   177 HTCALSWRESVHT---QKP----------PEHPL-------GQRHIRRRRDVVTETKT------- 214

  Fly   264 NKYSSYVELVIVVDN---KVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESN 325
                  ||||||.|:   :.|::||....:..:    :|.:::..:.|||:.|||||:..|.:.:
Human   215 ------VELVIVADHSEAQKYRDFQHLLNRTLE----VALLLDTFFRPLNVRVALVGLEAWTQRD 269

  Fly   326 EIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQ 390
            .:|.|.:..:||.|||::|...|:...|:|:|||:|..:|:|..||.|::..||:.::||||:|.
Human   270 LVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMD 334

  Fly   391 HSPNPAMVATTMAHEMGHNFGMEHDT--SDCHCRD----EKCVMAASSTSFIP-VNWSSCSIDQL 448
            ||.:...||:::|||:||:.|::||.  :.|.|..    :.|:|.| ||.|:| :|:|:||...|
Human   335 HSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEA-STDFLPGLNFSNCSRRAL 398

  Fly   449 TIAFSRGMNYCLRNKPERLFESPT----CGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNA 509
            ..|...||..||.   |||...|.    |||.|||||||||||..:.|.:.||::.||.|. ..|
Human   399 EKALLDGMGSCLF---ERLPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLR-PGA 459

  Fly   510 TCAT-GECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHG 573
            .||: |.||.  .|:.:.:|..||....:|||||:|.|:|..||.||...|.|||.||||.|.||
Human   460 QCASDGPCCQ--NCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHG 522

  Fly   574 TCRSHSNQCRTLWGPTGDNSEH-C-YNKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHL 636
            .|.|::.||::||||....:.. | ...||.|...|:||.|. :.:::.|..:...||.|.|  .
Human   523 RCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNP-SGSYVSCTPRDAICGQLQC--Q 584

  Fly   637 NERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPV 701
            ..|.:..:.|...|....|..:...:.|....:|||.....|.||..|..||...:|:|.||..|
Human   585 TGRTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRV 649

  Fly   702 DAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCS---KAGSGGSPDSGPATDPNGSVGF 763
            |.:.    .:.|...|:|:|:|:|..||:|:.|:....|:   ||.|            :.:.|.
Human   650 DLLG----AQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKATS------------SLTTGL 698

  Fly   764 KRFLYVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNG----TGPP 824
            ...|.||...|: :.|.:|:           |.:|...:.:..|.:  ...|..|:|    .|||
Human   699 LLSLLVLLVLVM-LGASYWY-----------RARLHQRLCQLKGPT--CQYRAAQSGPSERPGPP 749

  Fly   825 PSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFVQP 889
            ....|.:.|      ..::.|..|  :.||            |||  ...|.|......:|
Human   750 QRALLARGT------KQASALSFP--APPS------------RPL--PPDPVSKRLQAELA---- 788

  Fly   890 TVQQDGPQRMAPPPPVVK--PGTAPIHPPSPKPEATWVRPAPALPP--------PNPGSTARPII 944
             .:.:.|.|..|..|||:  ....|..||.|:      :|.||.|.        |.||:...|::
Human   789 -DRPNPPTRPLPADPVVRSPKSQGPAKPPPPR------KPLPADPQGRCPSGDLPGPGAGIPPLV 846

  Fly   945 SPPKLDSSTLTMVPLKDSTEDLSPSRSAPPVP 976
                                  .|||.|||.|
Human   847 ----------------------VPSRPAPPPP 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	29/111 (26%)
		Reprolysin	269..464	CDD:279729	78/204 (38%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	78/202 (39%)
		Disintegrin	479..555	CDD:278623	35/76 (46%)
		ACR	558..701	CDD:214743	50/144 (35%)
ADAM15	NP_997080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..45		7/32 (22%)
		Pep_M12B_propep	62..154	CDD:279848	26/102 (25%)
		Cysteine switch. /evidence=ECO:0000250	177..184		2/6 (33%)
		Reprolysin	213..413	CDD:279729	78/220 (35%)
		ZnMc_adamalysin_II_like	213..411	CDD:239797	77/215 (36%)
		DISIN	430..504	CDD:214490	35/76 (46%)
		Cell attachment site. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00068	484..486		0/1 (0%)
		ACR	508..649	CDD:214743	50/143 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..863		43/176 (24%)
		SH3-binding. /evidence=ECO:0000255	815..821		3/11 (27%)
		SH3-binding. /evidence=ECO:0000255	850..856		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I4140
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1788
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41556
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.000