DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and ADAM23

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_003803.1	Gene:	ADAM23 / 8745	HGNCID:	202	Length:	832	Species:	Homo sapiens

Alignment Length:	765	Identity:	220/765 - (28%)
Similarity:	349/765 - (45%)	Gaps:	137/765 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 NTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHT 79
            :..:|:.|..|:. ..::.::..:|..| ||:     |..|.|.:|.:             .:|.
Human   104 SNAMQKEITLPSR-LIYYINQDSESPYH-VLD-----TKARHQQKHNK-------------AVHL 148

  Fly    80 PQISLSYTHEGKRVVVDLQRNDLLLPNSHF-LRYQNA----SRGATPGHVVTTFTKTEVDLCHYQ 139
            .|.|......|.:.::||..|:.||.:.:. :.|:|.    |:|.              :.|:|.
Human   149 AQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQYSKGG--------------EHCYYH 199

  Fly   140 GHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYD 204
            |.|||..:|.||||||:| |.|:..|....|.|.|.
Human   200 GSIRGVKDSKVALSTCNG-LHGMFEDDTFVYMIEPL----------------------------- 234

  Fly   205 NHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTL-------------------LRKRRQA 250
                :..|| ||:.|.       |.:..:...|::|:.:                   |::|::|
Human   235 ----ELVHD-EKSTGR-------PHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRA 287

  Fly   251 DDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALY-VPLNIFVA 314
            .:.|   ||.:...|   |:||:||.|:|.||..:.:....:.:.|.:.|:::::| ..||..|.
Human   288 VNPS---RGIFEEMK---YLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVV 346

  Fly   315 LVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPIC 379
            ||.|..|.|.::|:.:::....|..|..||  :.:..|. |...|:::..|.......:..|.:|
Human   347 LVAVETWTEKDQIDITTNPVQMLHEFSKYR--QRIKQHA-DAVHLISRVTFHYKRSSLSYFGGVC 408

  Fly   380 TYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSD----CHCRDE--KCVMAASSTSFIPV 438
            :  .:.||.:.....|..||..::..:..|.|::.:.|.    |.|.:.  .|:|..:..|. ..
Human   409 S--RTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSH-SR 470

  Fly   439 NWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCM 503
            .:|.|||.:......||...||.|:|.:|||...||||:||.||:||||....|...||  :.|.
Human   471 KFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCC--KKCS 533

  Fly   504 LHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQA 568
            | |..|.|:.|.||:.|:|..:..|..||:|.||||:.|||||:|..||.::.::|...|:..|.
Human   534 L-SNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQG 597

  Fly   569 YCFHGTCRSHSNQCRTLWGPTGDNSE-HCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGML 631
            .|::|.|::..|||:.:||.....|: .||.| |||||..||||.:  ...:::|.:..|.||.|
Human   598 RCYNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKD--GDRWIQCSKHDVFCGFL 660

  Fly   632 HCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQ 696
            .|.:|......|.....::..|:. |..:::.|..|.|.|. ..||.|...:|..||...||:|:
Human   661 LCTNLTRAPRIGQLQGEIIPTSFY-HQGRVIDCSGAHVVLD-DDTDVGYVEDGTPCGPSMMCLDR 723

  Fly   697 RCLPVDAVRQKGMGKPCPED-----CNGNGICNSRGHCHCDVGFGGESCS 741
            :||.:.|:....    ||.|     |:|:|:|::...|.||..:.|..||
Human   724 KCLQIQALNMSS----CPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCS 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	32/114 (28%)
		Reprolysin	269..464	CDD:279729	53/201 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	52/199 (26%)
		Disintegrin	479..555	CDD:278623	36/75 (48%)
		ACR	558..701	CDD:214743	49/144 (34%)
ADAM23	NP_003803.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Pep_M12B_propep	127..249	CDD:396235	47/196 (24%)
		Reprolysin	299..496	CDD:396140	54/205 (26%)
		DISIN	511..585	CDD:214490	36/76 (47%)
		May bind the integrin receptor	563..568		3/4 (75%)
		ACR	587..726	CDD:214743	47/142 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9321
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920