DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and ADAM19

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_150377.1	Gene:	ADAM19 / 8728	HGNCID:	197	Length:	918	Species:	Homo sapiens

Alignment Length:	995	Identity:	321/995 - (32%)
Similarity:	449/995 - (45%)	Gaps:	177/995 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 CLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQ 81
            ||....|||....|..:....:..     ||.|      |:::|........|:.......|..:
Human    11 CLLAFALQPLRPRAAREPGWTRGS-----EEGS------PKLQHELIIPQWKTSESPVREKHPLK 64

  Fly    82 ISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKP 146
            ..|....||:.:::||::|:.|...|:...:..:|     |:..||..|.| |.|.|.|.:|...
Human    65 AELRVMAEGRELILDLEKNEQLFAPSYTETHYTSS-----GNPQTTTRKLE-DHCFYHGTVRETE 123

  Fly   147 ESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHS 211
            .|.|.||||.|....|.:....:|.|.|..|.:|:    |.:.:...:.|....||:: |....:
Human   124 LSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQ----HLIYRSEHLKPPPGNCGFE-HSKPTT 183

  Fly   212 HDYEKADGDNGLGGGIPSLPLRLDGGEFS-RTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIV 275
            .|:..                     :|: :|..|.||       :.|...|:.|   ||||.:|
Human   184 RDWAL---------------------QFTQQTKKRPRR-------MKREDLNSMK---YVELYLV 217

  Fly   276 VDNKVYKNFQEN------TKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGD 334
            .|   |..||:|      ||  |:..: |||.::..|..|||.:||||:.:|...|..|.|.:..
Human   218 AD---YLEFQKNRRDQDATK--HKLIE-IANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPY 276

  Fly   335 LTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVA 399
            .||.:||::| .||:....:|||||:|..:|.|..:|.|....:|:...||||:|.||.|...||
Human   277 STLWSFLSWR-RKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVA 340

  Fly   400 TTMAHEMGHNFGMEHDTSDC---HCRDEKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLR 461
            .||||||||||||.||::||   ...|..|:|||::....|..::.|:..:|......|...||.
Human   341 ATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLS 405

  Fly   462 NKPE--RLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGECCDLTTCRP 524
            |.|:  .|:....||||::|.||:||||..|.|.|.||||..|.|. ..|.||.|.||.  .|:.
Human   406 NMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLR-PGAECAHGSCCH--QCKL 467

  Fly   525 KLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPT 589
            ...|:.|||...:|||||:|||:|.:||.:.::.|..||:||||||::|.|.::..||:.||||.
Human   468 LAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPG 532

  Fly   590 GDNS-EHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSH 652
            ...: :.|:.| |..|...||||.: :|....:|..:...||.:.|.....|   .:||.||...
Human   533 ARPAPDLCFEKVNVAGDTFGNCGKD-MNGEHRKCNMRDAKCGKIQCQSSEAR---PLESNAVPID 593

  Fly   653 SYISHDRKIVACRTALVDLGLQ----TTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPC 713
            :.|..:.:.:.||...|..|.:    ..||||...|.|||.:.:|.:.:|........:|.||
Human   594 TTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGK-- 656

  Fly   714 PEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVV 778
              .|||:|:||:..:|||..|:....|:..|.|||.||||.  |..|||......::...||.|:
Human   657 --KCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPM--PPESVGPVVAGVLVAILVLAVL 717

  Fly   779 ALFWFLYHCYKNGMLTRGKLADNILKS---SGGSKPITTRTNQN-GTG---------PPPSNGLL 830
            .|.:  |.|.:|..|  |:|..:.|.|   ...|.|.  |.:|| |||         .|.....:
Human   718 MLMY--YCCRQNNKL--GQLKPSALPSKLRQQFSCPF--RVSQNSGTGHANPTFKLQTPQGKRKV 776

  Fly   831 KSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRP----LNDASSP----------ASNYNG 881
            .:||.        :|:.||...|             ||    |...|.|          |.|..|
Human   777 INTPE--------ILRKPSQPPP-------------RPPPDYLRGGSPPAPLPAHLSRAARNSPG 820

  Fly   882 PNVAF--------------VQPT----VQQD-----GPQRMAPPPPV------VKPGTA-PIHPP 916
            |....              :.|.    |.||     .||:..|..||      .:||.| |:.||
Human   821 PGSQIERTESSRRPPPSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPP 885

  Fly   917 SPKPEATWVRPAPALPPPNP 936
            ...|:.:  ||..||.|..|
Human   886 GAGPQQS--RPLAALAPKFP 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	31/109 (28%)
		Reprolysin	269..464	CDD:279729	84/203 (41%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	83/201 (41%)
		Disintegrin	479..555	CDD:278623	38/75 (51%)
		ACR	558..701	CDD:214743	50/148 (34%)
ADAM19	NP_150377.1	Pep_M12B_propep	58..161	CDD:279848	34/112 (30%)
		Cysteine switch. /evidence=ECO:0000250	130..137		4/6 (67%)
		Reprolysin	210..408	CDD:279729	85/207 (41%)
		ZnMc_adamalysin_II_like	210..406	CDD:239797	84/205 (41%)
		DISIN	439..499	CDD:214490	29/62 (47%)
		ACR	501..646	CDD:214743	50/148 (34%)
		SH3-binding. /evidence=ECO:0000255	833..844		1/10 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I4140
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74925
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1788
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	1	1.000	-	-		otm41556
orthoMCL	1	0.900	-	-		OOG6_101958
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.870