DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and adam28

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001070186.1	Gene:	adam28 / 767749	ZFINID:	ZDB-GENE-060929-532	Length:	293	Species:	Danio rerio

Alignment Length:	363	Identity:	100/363 - (27%)
Similarity:	151/363 - (41%)	Gaps:	78/363 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HLHLFLLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSL 67
            ||.|::..|     |:.   |.|        |.|...:.|.     ..|.::||...|...||.|
Zfish     5 HLMLWIFTL-----CVS---LDP--------SVGHIHELHR-----KVYEIVRPIGLHDLQKRDL 48

  Fly    68 LTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTE 132
            .:..|        ::..:.|..|:.:.:.||:|..:|...:...|....     |.:||| |..:
Zfish    49 QSRPD--------RVKYAMTLGGRDIEMHLQKNTGMLTKDYSETYYTED-----GMLVTT-TPAD 99

  Fly   133 VDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHP---HIDGRGRLQDDHYLLKQADM 194
            :|||:|.|.|.....|:|::||||| |.|......|...|.|   ..||      ||...|..|:
Zfish   100 LDLCYYHGKILNDSASLVSMSTCDG-LRGYFQTAEQRVLIEPLSEDSDG------DHAAFKYEDV 157

  Fly   195 H-PTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIR 258
            : .|...||..|...|.|            |.|:|.            .:|:.|.::...:...|
Zfish   158 NEATPRVCGVTNTTWDES------------GDGVPP------------RILKTRSRSSGPTLFQR 198

  Fly   259 GPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNE 323
            ..||        |..:|.||:.||....:.:|:.:....|.|.||.:|..:|.||||.|..:|.:
Zfish   199 QKYN--------EFFLVADNREYKKLNSDLEKLRKRIFEIINFINNVYKEINTFVALTGFEVWTD 255

  Fly   324 SNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLT 361
            :::|..|:....||.:|..:|::.|:....:|||.|||
Zfish   256 NDKITVSAASGATLDSFTKWRNSDLIKRQRHDNAHLLT 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	33/109 (30%)
		Reprolysin	269..464	CDD:279729	32/93 (34%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	32/93 (34%)
		Disintegrin	479..555	CDD:278623
		ACR	558..701	CDD:214743
adam28	NP_001070186.1	Pep_M12B_propep	44..149	CDD:279848	36/125 (29%)
adam28	NP_001070186.1	ZnMc_adamalysin_II_like	200..>293	CDD:239797	32/100 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010