DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and Adam30

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001103070.1	Gene:	Adam30 / 690547	RGDID:	1594713	Length:	726	Species:	Rattus norvegicus

Alignment Length:	785	Identity:	227/785 - (28%)
Similarity:	346/785 - (44%)	Gaps:	131/785 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 FSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSY--THEGKRVVVDLQRNDLLLPNSHFL 110
            |.:|.:..|:|         |:......|:.:   ||||  ..|||..||.|:...||||.
  Rat    36 FDSYEITIPKV---------LSLRKEAQGVDS---SLSYLLQIEGKERVVHLRPKKLLLPR---- 84

  Fly   111 RYQNASRGATPGHV-VTTFTKTE---------VDLCHYQGHIRGKPESVVALSTCDGALDGIV-I 164
                        |: |.:||:.:         .|.|:|.|.:.|..|:...||||.|.|.|:: |
  Rat    85 ------------HLPVFSFTQEDSLIEDYPHIPDQCNYVGFVEGSQEAESTLSTCMGGLRGVLNI 137

  Fly   165 DGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPS 229
            |.|. |.|.| :....|.:...|||.:.:.  .|.|||..:         |:.||...
  Rat   138 DSRY-YQIEP-LRASSRFEHVVYLLTEDNF--GNETCGVVD---------EETDGQTA------- 182

  Fly   230 LPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQY 294
                 :..|.:|               |:..:.:.|:..|:|||:|.|...|...:.|..::.:.
  Rat   183 -----EEEEVAR---------------IKNFHQSYKHQRYLELVMVFDLSRYVFTRGNMTRMVED 227

  Fly   295 CKGIANIINALYVPLNIFVALVGVVIWNESNEIE-FSSDGDLTLRNFLNYRSTKLVLDHPNDNAQ 358
            ...:|:|.:..:..:::.:.|..:.:|.:.::|. :.|.....|..|:.|:...|....|.|.|.
  Rat   228 AILLASIADTYFQDVSLKIQLKALEVWTQFDKIHLYYSSLSQVLGQFVLYKRASLHHRLPADWAH 292

  Fly   359 LLTKENFAGGVV---GKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCH 420
            |.....::....   |:|     |...::|..|...:.|....||..||||||..||.||...|.
  Rat   293 LYIARRYSDATAWSWGRA-----CEEFHAGSASSFLNVNLLGPATWTAHEMGHCVGMYHDEEFCQ 352

  Fly   421 CRDEK-CVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQC 484
            ||..| |||....|.|     |:||..|..:..|..|:|||.:.| :|.....|||..||..|:|
  Rat   353 CRGRKSCVMGTGRTGF-----SNCSYHQYFLHASYKMSYCLSDFP-KLHIVERCGNKIVENKEEC 411

  Fly   485 DCGLPEHCENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESE 549
            |||..|.|::..|....|. ..:...|::|.||......|  :|..|||.||||||.|||.|.|.
  Rat   412 DCGSEEECKSDLCCGPDCK-WKEGVNCSSGLCCHKCNFLP--SGYVCREEENECDLAEYCDGLSG 473

  Fly   550 YCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNS-EHCYNK-NTEGTRLGNCGYN 612
            :||.|.:::|..||..| .:|||..|||...||:.::|.....: ..||:. |..|.:.||||.
  Rat   474 FCPKDYYKQDGTPCRYG-GFCFHKGCRSRYLQCQAIFGRRAKEAPRQCYDAVNMIGDQSGNCGI- 536

  Fly   613 RLNKT-FLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVAC-----RTALVDL 671
             :|.| :.:|...:..||.|.|:::.....|  ....:|..:::..|.  :.|     ...::..
  Rat   537 -VNATRYTKCHRDNTICGRLQCVNIKALSRF--PDHTLLLSTHLKKDN--LKCWGTSYHGTMIPH 596

  Fly   672 GLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFG 736
            |:  .|.|...:|..||.:::|:::.|:....::...:    |:.||..|:||::.:|||..|:.
  Rat   597 GV--PDIGDVNDGTSCGPNRVCLNRTCVDYATLKFDCL----PKKCNSRGVCNNKKNCHCTYGWE 655

  Fly   737 GESCSKAGSGGSPDSGPATDPNGSVGFKRFLY----VLFFFVLPVVALFWFLYHCY-----KNGM 792
            ...|.:.|.|||.|||| ..|...:.....||    :||.|.:.||.....:.:.:     ||..
  Rat   656 PPFCVEVGYGGSIDSGP-PGPRARLAKVHVLYMLRTILFIFSVIVVCFTQRMKNLFRKRQQKNPA 719

  Fly   793 LTRGK 797
            .|:||
  Rat   720 ETQGK 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	38/122 (31%)
		Reprolysin	269..464	CDD:279729	58/199 (29%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	58/197 (29%)
		Disintegrin	479..555	CDD:278623	32/75 (43%)
		ACR	558..701	CDD:214743	40/150 (27%)
Adam30	NP_001103070.1	Pep_M12B_propep	48..157	CDD:279848	39/129 (30%)
		Reprolysin	201..392	CDD:279729	58/200 (29%)
		ZnMc_adamalysin_II_like	201..390	CDD:239797	58/198 (29%)
		Disintegrin	406..478	CDD:278623	32/74 (43%)
		ACR	482..623	CDD:214743	40/149 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920